Abstract：
:Drosophila Reaper (RPR), Head Involution Defective (HID), and GRIM induce caspase-dependent cell death and physically interact with the cell death inhibitor DIAP1. Here we show that HID blocks DIAP1's ability to inhibit caspase activity and provide evidence suggesting that RPR and GRIM can act similarly. Based on these results, we propose that RPR, HID, and GRIM promote apoptosis by disrupting productive IAP-caspase interactions and that DIAP1 is required to block apoptosis-inducing caspase activity. Supporting this hypothesis, we show that elimination of DIAP1 function results in global early embryonic cell death and a large increase in DIAP1-inhibitable caspase activity and that DIAP1 is still required for cell survival when expression of rpr, hid, and grim is eliminated.
journal_name
Celljournal_title
Cellauthors
Wang SL,Hawkins CJ,Yoo SJ,Müller HA,Hay BAdoi
10.1016/s0092-8674(00)81974-1subject
Has Abstractpub_date
1999-08-20 00:00:00pages
453-63issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81974-1journal_volume
98pub_type
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