Abstract:
:Mice homozygous for a targeted mutation of the Hoxa-2 (Hox 1.11) gene are born with cleft palates and die within 24 hr of birth. Analysis of stained skeletons revealed that homozygous mutant animals contained multiple cranial skeletal defects, including a duplication of the ossification centers of the bones of the middle ear. Histological analysis suggested that this duplication resulted from the transformation of skeletal elements derived from the second branchial arch into more anterior structures, resulting in a duplication of Meckel's cartilage adjacent to the otic capsule. Skeletal elements normally derived from the second arch were absent in the mutants. These data provide direct experimental evidence for the existence of a branchial Hox code.
journal_name
Celljournal_title
Cellauthors
Gendron-Maguire M,Mallo M,Zhang M,Gridley Tdoi
10.1016/0092-8674(93)90619-2subject
Has Abstractpub_date
1993-12-31 00:00:00pages
1317-31issue
7eissn
0092-8674issn
1097-4172pii
0092-8674(93)90619-2journal_volume
75pub_type
杂志文章相关文献
CELL文献大全abstract::xol-1 is the earliest-acting gene in the known hierarchy that controls C. elegans sex determination and dosage compensation. We show that the primary sex-determining signal (the X/A ratio) directs the choice of sexual fate by regulating xol-1 transcript levels: high xol-1 expression during gastrulation triggers male d...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90452-2
更新日期:1995-01-13 00:00:00
abstract::Discs large (DLG) mediates the clustering of synaptic molecules. Here we demonstrate that synaptic localization of DLG itself is regulated by CaMKII. We show that DLG and CaMKII colocalize at synapses and exist in the same protein complex. Constitutively activated CaMKII phenocopied structural abnormalities of dlg mut...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81964-9
更新日期:1999-08-06 00:00:00
abstract::We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene. This mutation eliminates expression of gp145trkB, a protein-tyrosine kinase that serves as the signaling receptor for two members of the nerve growth factor family of neurotrophins, brain-derived neurotrophic ...
journal_title:Cell
pub_type: 杂志文章
doi:
更新日期:1993-10-08 00:00:00
abstract::Recent work has identified a cascade of membrane bound protein kinases in Ehrlich ascites tumor cells. These enzymes, designated PKL, PKS and PKM, are present in both Ehrlich tumor and mouse brain, but the cascade is active only in the tumor tissue. We have now purified a fourth protein kinase, PKF, that is also assoc...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90227-0
更新日期:1981-07-01 00:00:00
abstract::Sexual reproduction predominates among eukaryotic organisms on our planet. While debate continues over why this should be so, burgeoning genomic and functional information now allows us to begin to think reasonably about some of the events that may have occurred to make sex possible in the first place. ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(01)00500-1
更新日期:2001-09-21 00:00:00
abstract::Rosalind Franklin provided the key data for deriving the double helix structure of DNA. The English chemist also pioneered structural studies of colloids, viruses, and RNA. To celebrate the 100th anniversary of Franklin's birth, I summarize her work, which shaped the emerging discipline of molecular biology. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.07.028
更新日期:2020-08-20 00:00:00
abstract::Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known l...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90530-8
更新日期:1995-06-02 00:00:00
abstract::Information processing relies on precise patterns of synapses between neurons. The cellular recognition mechanisms regulating this specificity are poorly understood. In the medulla of the Drosophila visual system, different neurons form synaptic connections in different layers. Here, we sought to identify candidate ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.11.021
更新日期:2015-12-17 00:00:00
abstract::Upon exposure to 0.1 mM N-phosphonacetyl-L-aspartate (PALA), a transition state analog inhibitor of aspartate transcarbamylase, most cells of a simian virus 40 (SV40)-transformed Syrian hamster line are killed within a few days, but resistant mutants form spontaneously with frequency 2-5 X 10(-5) in a stochastic proce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(76)90036-2
更新日期:1976-12-01 00:00:00
abstract::Netrins are bifunctional: they attract some axons and repel others. Netrin receptors of the Deleted in Colorectal Cancer (DCC) family are implicated in attraction and those of the UNC5 family in repulsion, but genetic evidence also suggests involvement of the DCC protein UNC-40 in some cases of repulsion. To test whet...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80804-1
更新日期:1999-06-25 00:00:00
abstract::The mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and facilitating their hybridization with cognate preedited mRNAs. To understand the mechanism by which this complex pe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.06.047
更新日期:2006-08-25 00:00:00
abstract::Clinical benefits of cytokine blockade in ileal Crohn's disease (iCD) are limited to a subset of patients. Here, we applied single-cell technologies to iCD lesions to address whether cellular heterogeneity contributes to treatment resistance. We found that a subset of patients expressed a unique cellular module in inf...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.08.008
更新日期:2019-09-05 00:00:00
abstract::The crystal structure of the snake toxin fasciculin, bound to mouse acetylcholinesterase (mAChE), at 3.2 A resolution reveals a synergistic three-point anchorage consistent with the picomolar dissociation constant of the complex. Loop II of fasciculin contains a cluster of hydrophobic residues that interact with the p...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90128-0
更新日期:1995-11-03 00:00:00
abstract::Overlapping cDNA clones from the translocation breakpoint region (TBR) gene, recently discovered at the neurofibromatosis type 1 locus and found to be interrupted by deletions and a t(17;22) translocation, have been sequenced. A 4 kb sequence of the transcript of the TBR gene has been compared with sequences of genomi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90253-b
更新日期:1990-07-13 00:00:00
abstract::Alternative splicing (AS) patterns have diverged rapidly during vertebrate evolution, yet the functions of most species- and lineage-specific splicing events are not known. We observe that mammalian-specific AS events are enriched in transcript sequences encoding intrinsically disordered regions (IDRs) of proteins, in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.06.037
更新日期:2017-07-13 00:00:00
abstract::Mitochondrial DNA from bovine tissue contains heterogeneous sequences located within an evolutionary conserved cytosine homopolymer sequence near the 5' end of the D-loop region. This part of the mammalian mitochondrial genome is known to contain the origin of heavy strand DNA synthesis and the major transcriptional p...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90434-3
更新日期:1984-07-01 00:00:00
abstract::T cells expressing chimeric antigen receptors (CARs) are promising cancer therapeutic agents, with the prospect of becoming the ultimate smart cancer therapeutics. To expand the capability of CAR T cells, here, we present a split, universal, and programmable (SUPRA) CAR system that simultaneously encompasses multiple ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.038
更新日期:2018-05-31 00:00:00
abstract::A major part of virulence for Plasmodium falciparum malaria infection, the most lethal parasitic disease of humans, results from increased rigidity and adhesiveness of infected host red cells. These changes are caused by parasite proteins exported to the erythrocyte using novel trafficking machinery assembled in the h...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.04.051
更新日期:2008-07-11 00:00:00
abstract::Isolated human mitochondria containing a mitochondrial DNA (mtDNA) coded chloramphenicol resistance marker were injected into cells from two different human sensitive cell lines, 143BTK- and HT1080-6TG, which had been partially depleted of their mtDNA by ethidium bromide treatment. On the basis of the available eviden...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(88)90423-0
更新日期:1988-03-25 00:00:00
abstract::Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.05.003
更新日期:2010-06-11 00:00:00
abstract::Mutations in the C. elegans gene ced-3 prevent almost all programmed cell deaths, so that in a ced-3 mutant there are many extra cells. We show that the pharyngeal neuron M4 is essential for feeding in wild-type worms, but in a ced-3 mutant, one of the extra cells, probably MSpaaaaap (the sister of M4), can sometimes ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(87)90593-9
更新日期:1987-12-24 00:00:00
abstract::Iron is ubiquitous in the environment and in biology. The study of iron biology focuses on physiology and homeostasis-understanding how cells and organisms regulate their iron content, how diverse tissues orchestrate iron allocation, and how dysregulated iron homeostasis leads to common hematological, metabolic, and n...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/s0092-8674(04)00343-5
更新日期:2004-04-30 00:00:00
abstract::CRISPR-Cas9 technology would be enhanced by the ability to inhibit Cas9 function spatially, temporally, or conditionally. Previously, we discovered small proteins encoded by bacteriophages that inhibit the CRISPR-Cas systems of their host bacteria. These "anti-CRISPRs" were specific to type I CRISPR-Cas systems that d...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.11.017
更新日期:2016-12-15 00:00:00
abstract::Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast cancer. Intriguingly, TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and, hence, to PKCα. The latter kinase phosphorylates and activates JAK2, leading to ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.06.009
更新日期:2016-06-30 00:00:00
abstract::Misfolded proteins of the ER are retrotranslocated to the cytosol, where they are polyubiquitinated, extracted from the membrane, and degraded by the proteasome. To investigate how the ER-associated Degradation (ERAD) machinery can accomplish retrotranslocation of a misfolded luminal protein domain across a lipid bila...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.048
更新日期:2016-07-14 00:00:00
abstract::Micronuclei of Tetrahymena thermophila contain two electrophoretically distinct forms of histone H3. The slower migrating micronuclear species, H3S, is indistinguishable from the macronuclear H3 by electrophoretic analyses in three gel systems and by partial proteolytic peptide mapping. The faster species, H3F, is uni...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90234-2
更新日期:1980-05-01 00:00:00
abstract::We have characterized an aberrant allele of a variably spliced Drosophila tropomyosin gene. The allele was recovered from the flightless Ifm(3)3 strain, which has been shown to have structurally and functionally abnormal indirect flight muscles. The transcribed portion of the mutant gene is interrupted by an 8,8 kb in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90061-3
更新日期:1985-05-01 00:00:00
abstract::The cpd mutation localized by T-DNA tagging on Arabidopsis chromosome 5-14.3 inhibits cell elongation controlled by the ecdysone-like brassinosteroid hormone brassinolide. The cpd mutant displays de-etiolation and derepression of light-induced genes in the dark, as well as dwarfism, male sterility, and activation of s...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81094-6
更新日期:1996-04-19 00:00:00
abstract::Murine intracisternal A particles have a number of properties which are common to known RNA tumor viruses, but horizontal transmission has not been previously demonstrated. The apparent absence of infectivity may be related to the failure of these particles to be released from cisternae of endo-plasmic reticulum. Prev...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(76)90083-0
更新日期:1976-11-01 00:00:00
abstract::Developing systems exhibit robust and tolerant properties in the form of compensation and competition within cell groups. Fundamentally, these behaviors are governed by mechanisms that elicit proliferation and apoptosis. Recent insights from the Drosophila system implicate new determinants that specify "winners" and "...
journal_title:Cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s0092-8674(02)00904-2
更新日期:2002-08-23 00:00:00