Abstract:
:The temperature-sensitive mutant of yeast, rna2-, when incubated at the nonpermissive temperature, has a qualitatively distinct distribution of mRNA sequences as compared to wild-type. Quantitative comparison with the wild-type distribution indicates that after 1 hr at the nonpermissive temperature, the concentration of approximately 100-150 abundant sequences is significantly decreased. Control experiments indicate that this effect is not simply a function of the increase in incubation temperature nor a general effect on all mRNAs. Gorenstein and Warner (1976) have shown that the synthesis of ribosomal proteins is preferentially depressed at the non-permissive temperature in rna2-. It is proposed that among these 100-150 sequences are the mRNAs which code for the ribosomal proteins.
journal_name
Celljournal_title
Cellauthors
Hereford LM,Rosbash Mdoi
10.1016/0092-8674(77)90033-2subject
Has Abstractpub_date
1977-03-01 00:00:00pages
463-7issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(77)90033-2journal_volume
10pub_type
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