Abstract：
:Planar polarity is a global, tissue-level phenomenon that coordinates cell behavior in a two-dimensional plane. The Frizzled/planar cell polarity (PCP) and anterior-posterior (AP) patterning systems for planar polarity operate in a variety of cell types and provide direction to cells with different morphologies and behaviors. These two systems involve different sets of proteins but both use directional cues provided locally by communication between neighboring cells. This review describes our current understanding of the mechanisms that transmit directional signals from cell to cell and compares the strategies for generating global systems of spatial information in stationary and dynamic cell populations.
journal_name
Celljournal_title
Cellauthors
Zallen JAdoi
10.1016/j.cell.2007.05.050subject
Has Abstractpub_date
2007-06-15 00:00:00pages
1051-63issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(07)00725-8journal_volume
129pub_type
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