Abstract：
:Reactive oxygen species (ROS) and mitochondrial defects in neurons are implicated in neurodegenerative disease. Here, we find that a key consequence of ROS and neuronal mitochondrial dysfunction is the accumulation of lipid droplets (LD) in glia. In Drosophila, ROS triggers c-Jun-N-terminal Kinase (JNK) and Sterol Regulatory Element Binding Protein (SREBP) activity in neurons leading to LD accumulation in glia prior to or at the onset of neurodegeneration. The accumulated lipids are peroxidated in the presence of ROS. Reducing LD accumulation in glia and lipid peroxidation via targeted lipase overexpression and/or lowering ROS significantly delays the onset of neurodegeneration. Furthermore, a similar pathway leads to glial LD accumulation in Ndufs4 mutant mice with neuronal mitochondrial defects, suggesting that LD accumulation following mitochondrial dysfunction is an evolutionarily conserved phenomenon, and represents an early, transient indicator and promoter of neurodegenerative disease.
journal_name
Celljournal_title
Cellauthors
Liu L,Zhang K,Sandoval H,Yamamoto S,Jaiswal M,Sanz E,Li Z,Hui J,Graham BH,Quintana A,Bellen HJdoi
10.1016/j.cell.2014.12.019subject
Has Abstractpub_date
2015-01-15 00:00:00pages
177-90issue
1-2eissn
0092-8674issn
1097-4172pii
S0092-8674(14)01589-Xjournal_volume
160pub_type
杂志文章相关文献
CELL文献大全abstract：:Hsp33, a member of a newly discovered heat shock protein family, was found to be a very potent molecular chaperone. Hsp33 is distinguished from all other known molecular chaperones by its mode of functional regulation. Its activity is redox regulated. Hsp33 is a cytoplasmically localized protein with highly reactive c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80547-4
更新日期：1999-02-05 00:00:00
abstract：:We have employed repeat units of herpes simplex virus (HSV) defective genomes to derive a cloning-amplifying vector (amplicon) that can replicate in eucaryotic cells in the presence of standard HSV helper virus. The design of the HSV amplicon system is based on the previous observation that cotransfection of cells wit...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90035-6
更新日期：1982-08-01 00:00:00
abstract：:Lineage tracing is the identification of all progeny of a single cell. Although its origins date back to developmental biology of invertebrates in the 19(th) century, lineage tracing is now an essential tool for studying stem cell properties in adult mammalian tissues. Lineage tracing provides a powerful means of unde...
journal_title：Cell
pub_type： 历史文章,杂志文章
doi：10.1016/j.cell.2012.01.002
更新日期：2012-01-20 00:00:00
abstract：:Toxins have evolved to target regions of membrane ion channels that underlie ligand binding, gating, or ion permeation, and have thus served as invaluable tools for probing channel structure and function. Here, we describe a peptide toxin from the Earth Tiger tarantula that selectively and irreversibly activates the c...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.03.052
更新日期：2010-05-28 00:00:00
abstract：:Elucidating the regulatory mechanisms of human brain evolution is essential to understanding human cognition and mental disorders. We generated multi-omics profiles and constructed a high-resolution map of 3D genome architecture of rhesus macaque during corticogenesis. By comparing the 3D genomes of human, macaque, an...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2021.01.001
更新日期：2021-01-22 00:00:00
abstract：:We have generated mice carrying a germline mutation in the tyrosine kinase catalytic domain of the trkB gene. This mutation eliminates expression of gp145trkB, a protein-tyrosine kinase that serves as the signaling receptor for two members of the nerve growth factor family of neurotrophins, brain-derived neurotrophic ...
journal_title：Cell
pub_type： 杂志文章
doi：
更新日期：1993-10-08 00:00:00
abstract：:Assessing the real-world impact of biomedical research is notoriously difficult. Here, we present the framework for building a prospective science-centered information system from scratch that has been afforded by the Sidra Medical and Research Center in Qatar. This experiment is part of the global conversation on max...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.03.004
更新日期：2016-03-24 00:00:00
abstract：:How transcription is silenced in early embryos has long been a mystery. In this issue, Guven-Ozkan et al. (2008) report that transcriptional repression during worm embryogenesis is mediated through sequestration of the general transcription factor TAF-4 and is regulated by mechanisms that orchestrate the transition be...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2008.09.021
更新日期：2008-10-03 00:00:00
abstract：:To initiate a genetic study of the hormonal regulation of genes coding for the three vitellogenins or yolk polypeptide precursors (YPs) in Drosophila, we have isolated from wild flies genetic variants which alter the mobility in SDS-PAGE of each YP independently. These variants are expressed codominantly and they are ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90313-x
更新日期：1980-07-01 00:00:00
abstract：:Academic travel has a substantial carbon footprint. The ongoing pandemic has propelled the development and adoption of technologies for online delivery of seminars and remote attendance at scientific conferences. This should not lead to the complete elimination of in-person events, but the scientific community must se...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.07.026
更新日期：2020-08-20 00:00:00
abstract：:Mobile DNAs have had a central role in shaping our genome. More than half of our DNA is comprised of interspersed repeats resulting from replicative copy and paste events of retrotransposons. Although most are fixed, incapable of templating new copies, there are important exceptions to retrotransposon quiescence. De n...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2012.04.019
更新日期：2012-05-11 00:00:00
abstract：:We propose a mechanism for the priming of influenza viral RNA transcription by capped RNAs in which specific 5'-terminal fragments are cleaved from the capped RNAs by a virion-associated endonuclease. These fragments would serve as the actual primers for the initiation of transcription by the initial incorporation by ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90449-9
更新日期：1981-03-01 00:00:00
abstract：:Using a cloned cDNA complementary to a portion of the mRNA for the 50 kd human epidermal keratin, we have screened a human genomic library and have isolated and sequenced the gene encoding this keratin. A comparison of the keratin gene with the very distantly related vimentin gene has enabled us to explore the relatio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90456-2
更新日期：1984-12-01 00:00:00
abstract：:Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of t...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2020.03.003
更新日期：2020-04-02 00:00:00
abstract：:Behavioral expression of food-associated memory in fruit flies is constrained by satiety and promoted by hunger, suggesting an influence of motivational state. Here, we identify a neural mechanism that integrates the internal state of hunger and appetitive memory. We show that stimulation of neurons that express neuro...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.08.035
更新日期：2009-10-16 00:00:00
abstract：:Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regene...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.02.016
更新日期：2015-04-09 00:00:00
abstract：:One of the important events in synapse formation is the accumulation of neurotransmitter receptors beneath the presynaptic nerve terminal. Agrin is a component of the synaptic basal lamina that induces the clustering of acetylcholine receptors when bath-applied to muscle fibers in culture. When a cDNA encoding a putat...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90364-5
更新日期：1991-11-29 00:00:00
abstract：:Elucidating the global and local rules that govern genome-wide, hierarchical chromatin architecture remains a critical challenge. Current high-throughput chromosome conformation capture (Hi-C) technologies have identified large-scale chromatin structural motifs, such as topologically associating domains and looping. H...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.12.014
更新日期：2019-01-24 00:00:00
abstract：:Two allelic forms of the natural chicken ovalbumin gene have been independently cloned. These alleles differ from each other by an Eco RI restriction cleavage site in one of the seven intervening sequences within the natural ovalbumin gene. Restriction endonuclease mapping and sequence analyses of these cloned genotyp...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90201-0
更新日期：1979-01-01 00:00:00
abstract：:Drosophila bicoid mRNA is synthesized in the nurse cells and transported to the oocyte where microtubules and Exuperantia protein mediate localization to the anterior pole. Fluorescent bicoid mRNA injected into the oocyte displays nonpolar microtubule-dependent transport to the closest cortical surface, and the oocyte...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00419-6
更新日期：2001-07-13 00:00:00
abstract：:In this study, we have located the sites of transcription initiation and termination on a cloned fragment of ribosomal DNA from X. laevis, and have sequenced the surrounding nucleotides. As reported previously (Reeder, Sollner-Webb and Wahn, 1977), about 25% of the 40S rRNA precursor molecules isolated from oocytes ha...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90066-7
更新日期：1979-10-01 00:00:00
abstract：:In yeast, hyperosmotic stress causes an immediate dissociation of most proteins from chromatin, presumably because cells are unprepared for, and initially unresponsive to, increased ion concentrations in the nucleus. Osmotic stress activates Hog1 MAP kinase, which phosphorylates at least two proteins located at the pl...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.07.016
更新日期：2004-08-06 00:00:00
abstract：:Mouse plasmacytoma (MOPC) 460 cells contain two chromatographic forms of RNA polymerase III (IIIA and IIIB) in addition to the major class I and II RNA polymerases. Nuclei isolated from these cells actively synthesize RNA. Among the discrete transcription products observed are the 5S and 4.5S RNAs and additional low m...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90028-9
更新日期：1977-03-01 00:00:00
abstract：:Ras-related GTPases are positively regulated by guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP. The crystal structure of the Sec7 domain GEF bound to nucleotide-free ARF1 GTPase has been determined at 2.8 A resolution and the structure of ARF1 in the GTP-analog form determined at 1...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81754-7
更新日期：1998-10-16 00:00:00
abstract：:Synaptotagmin is an abundant synaptic vesicle-associated protein proposed to be involved in calcium-mediated neurotransmitter release. Our molecular and genetic results demonstrate that, although synaptotagmin is required for the proper function of the presynaptic nerve terminal in C. elegans, some neurotransmitter re...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90357-v
更新日期：1993-07-02 00:00:00
abstract：:Fibrillar protein aggregates are the major pathological hallmark of several incurable, age-related, neurodegenerative disorders. These aggregates typically contain aggregation-prone pathogenic proteins, such as amyloid-beta in Alzheimer's disease and alpha-synuclein in Parkinson's disease. It is, however, poorly under...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.07.020
更新日期：2010-08-20 00:00:00
abstract：:Chromosome segregation at meiosis I depends on pairing and crossing-over between homologs. In most eukaryotes, pairing culminates with formation of the proteinaceous synaptonemal complex (SC). In budding yeast, recombination initiates through double-strand DNA breaks (DSBs) and is thought to be essential for SC format...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81481-6
更新日期：1998-08-07 00:00:00
abstract：:The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain lamination and normal dendritogenesis, but the specific mechanisms underlying these actions remain unclear. We find that Stk25, a modifier of Reelin-Dab1 signaling, regulates Golgi morphology and neuronal polarization as part of an LKB1-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.10.029
更新日期：2010-11-24 00:00:00
abstract：:Transcriptional regulation by the glucocorticoid receptor (GR) is mediated by hormone binding, receptor dimerization, and coactivator recruitment. Here, we report the crystal structure of the human GR ligand binding domain (LBD) bound to dexamethasone and a coactivator motif derived from the transcriptional intermedia...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(02)00817-6
更新日期：2002-07-12 00:00:00
abstract：:The broad expression of the insulin receptor suggests that the spectrum of insulin function has not been fully described. A cell type expressing this receptor is the osteoblast, a bone-specific cell favoring glucose metabolism through a hormone, osteocalcin, that becomes active once uncarboxylated. We show here that i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.06.003
更新日期：2010-07-23 00:00:00
