Abstract：
:Mobile DNAs have had a central role in shaping our genome. More than half of our DNA is comprised of interspersed repeats resulting from replicative copy and paste events of retrotransposons. Although most are fixed, incapable of templating new copies, there are important exceptions to retrotransposon quiescence. De novo insertions cause genetic diseases and cancers, though reliably detecting these occurrences has been difficult. New technologies aimed at uncovering polymorphic insertions reveal that mobile DNAs provide a substantial and dynamic source of structural variation. Key questions going forward include how and how much new transposition events affect human health and disease.
journal_name
Celljournal_title
Cellauthors
Burns KH,Boeke JDdoi
10.1016/j.cell.2012.04.019subject
Has Abstractpub_date
2012-05-11 00:00:00pages
740-52issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(12)00517-Xjournal_volume
149pub_type
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