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TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective.

Abstract：

:T cells detect infection of cells by recognizing peptide fragments of foreign proteins bound to class I molecules of the major histocompatibility complex (MHC) on the surface of the infected cell. MHC class I molecules bind peptide in the endoplasmic reticulum, and analysis of mutant cells has demonstrated that an adequate supply of peptides requires the presence of two genes in the MHC class II locus that encode proteins called transporters associated with antigen processing (TAP) 1 and 2. TAP1 and TAP2 are members of the ATP-binding cassette family of membrane translocators. In this study, we demonstrate in a cell-free system that TAP1 is part of an ATP-dependent, sequence-specific, peptide translocator.

journal_name

Cell

journal_title

Cell

authors

Shepherd JC,Schumacher TN,Ashton-Rickardt PG,Imaeda S,Ploegh HL,Janeway CA Jr,Tonegawa S

doi

10.1016/0092-8674(93)80058-m

subject

Has Abstract

pub_date

1993-08-13 00:00:00

pages

577-84

issue

3

eissn

0092-8674

issn

1097-4172

pii

0092-8674(93)80058-M

journal_volume

74

pub_type

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