Abstract：
:The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles underlying their pathway-specific modulation of target regions are not well understood. Here, we dissect the mechanisms underlying BG direct and indirect pathway-mediated control of the mesencephalic locomotor region (MLR), a brainstem target of BG that is critical for locomotion. We optogenetically dissect the locomotor function of the three neurochemically distinct cell types within the MLR: glutamatergic, GABAergic, and cholinergic neurons. We find that the glutamatergic subpopulation encodes locomotor state and speed, is necessary and sufficient for locomotion, and is selectively innervated by BG. We further show activation and suppression, respectively, of MLR glutamatergic neurons by direct and indirect pathways, which is required for bidirectional control of locomotion by BG circuits. These findings provide a fundamental understanding of how BG can initiate or suppress a motor program through cell-type-specific regulation of neurons linked to specific actions.
journal_name
Celljournal_title
Cellauthors
Roseberry TK,Lee AM,Lalive AL,Wilbrecht L,Bonci A,Kreitzer ACdoi
10.1016/j.cell.2015.12.037subject
Has Abstractpub_date
2016-01-28 00:00:00pages
526-37issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(15)01701-8journal_volume
164pub_type
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