Abstract:
:The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption may benefit from a greater consideration of a codon's neighborhood within an mRNA than has been broadly applied. This Review examines the evidence for context cues in translation, with a focus on several recent studies that reveal broad roles for mRNA context in programming translation start sites, the rate of translation elongation, and stop codon identity.
journal_name
Celljournal_title
Cellauthors
Brar GAdoi
10.1016/j.cell.2016.09.022subject
Has Abstractpub_date
2016-12-15 00:00:00pages
1681-1692issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(16)31255-7journal_volume
167pub_type
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