Beyond the Triplet Code: Context Cues Transform Translation.

Abstract:

:The elucidation of the genetic code remains among the most influential discoveries in biology. While innumerable studies have validated the general universality of the code and its value in predicting and analyzing protein coding sequences, established and emerging work has also suggested that full genome decryption may benefit from a greater consideration of a codon's neighborhood within an mRNA than has been broadly applied. This Review examines the evidence for context cues in translation, with a focus on several recent studies that reveal broad roles for mRNA context in programming translation start sites, the rate of translation elongation, and stop codon identity.

journal_name

Cell

journal_title

Cell

authors

Brar GA

doi

10.1016/j.cell.2016.09.022

subject

Has Abstract

pub_date

2016-12-15 00:00:00

pages

1681-1692

issue

7

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(16)31255-7

journal_volume

167

pub_type

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