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Synthesis of H1 histones by BHK cells in G1.

Abstract：

:The synthesis of histones and DNA was examined in BHK cells arrested in G1 by isoleucine starvation and in cells progressing into the S phase upon isoleucine refeeding. Approximately 2-3% of the cells were not arrested in G1 and synthesized DNA. The rate of synthesis of DNA and nucleosomal histones observed in cells starved for isoleucine could be accounted for by the presence of these asynchronous cells. Synthesis of H1 histones by cells in G1, however, was 3 times that of the nucleosomal histones and approximately 15% of the rate of H1 histone synthesis in mid-S. Upon entry into S, the histones were synthesized in the same molar ratio in which they are present in chromatin. The possible biological significance of H1 histone synthesis in G1 cells and its implications for the regulatory mechanisms controlling histome synthesis are discussed.

journal_name

Cell

journal_title

Cell

authors

Tarnowka MA,Baglioni C,Basilico C

doi

10.1016/0092-8674(78)90092-2

subject

Has Abstract

pub_date

1978-09-01 00:00:00

pages

163-71

issue

1

eissn

0092-8674

issn

1097-4172

pii

0092-8674(78)90092-2

journal_volume

15

pub_type

杂志文章

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