Abstract:
:The mitochondrial unfolded protein response (UPRmt) can be triggered in a cell-non-autonomous fashion across multiple tissues in response to mitochondrial dysfunction. The ability to communicate information about the presence of mitochondrial stress enables a global response that can ultimately better protect an organism from local mitochondrial challenges. We find that animals use retromer-dependent Wnt signaling to propagate mitochondrial stress signals from the nervous system to peripheral tissues. Specifically, the polyQ40-triggered activation of mitochondrial stress or reduction of cco-1 (complex IV subunit) in neurons of C. elegans results in the Wnt-dependent induction of cell-non-autonomous UPRmt in peripheral cells. Loss-of-function mutations of retromer complex components that are responsible for recycling the Wnt secretion-factor/MIG-14 prevent Wnt secretion and thereby suppress cell-non-autonomous UPRmt. Neuronal expression of the Wnt ligand/EGL-20 is sufficient to induce cell-non-autonomous UPRmt in a retromer complex-, Wnt signaling-, and serotonin-dependent manner, clearly implicating Wnt signaling as a strong candidate for the "mitokine" signal.
journal_name
Celljournal_title
Cellauthors
Zhang Q,Wu X,Chen P,Liu L,Xin N,Tian Y,Dillin Adoi
10.1016/j.cell.2018.06.029subject
Has Abstractpub_date
2018-08-09 00:00:00pages
870-883.e17issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(18)30797-9journal_volume
174pub_type
杂志文章相关文献
CELL文献大全abstract::Developmental signaling pathways needed to evolve to be robust against environmental fluctuations. In this issue, Shimizu et al. reveal a complex system of interacting endocytic pathways that help to maintain consistent levels of Notch activity across a range of temperatures. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.05.007
更新日期:2014-05-22 00:00:00
abstract::Endoplasmic reticulum (ER) membrane contact sites (MCSs) mark positions where endosomes undergo fission for cargo sorting. To define the role of ER at this unique MCS, we targeted a promiscuous biotin ligase to cargo-sorting domains on endosome buds. This strategy identified the ER membrane protein TMCC1, a member of ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.08.030
更新日期:2018-09-20 00:00:00
abstract::Cultured hippocampal neurons were infected with a temperature-sensitive mutant of vesicular stomatitis virus (VSV) and a wild-type strain of the avian influenza fowl plague virus (FPV). The intracellular distribution of viral glycoproteins was monitored by immunofluorescence microscopy. In mature, fully polarized neur...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90240-f
更新日期:1990-07-13 00:00:00
abstract::We examine the interaction between polyoma-virus-encoded middle tumor antigen and the cellular src gene product, pp60c-src, using a series of monoclonal antibodies that recognize mammalian pp60c-src. Our results show that infection of mouse cells with transformation-competent strains of polyoma virus results in the st...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90272-1
更新日期:1984-10-01 00:00:00
abstract::Significant advances have been made in developing novel therapeutics for cancer treatment, and targeted therapies have revolutionized the treatment of some cancers. Despite the promise, only about five percent of new cancer drugs are approved, and most fail due to lack of efficacy. The indication is that current precl...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2015.08.068
更新日期:2015-09-24 00:00:00
abstract::This article has been retracted: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our-business/policies/article-withdrawal). This article has been retracted at the request of request of the editors. Cell is retracting this paper reporting structures of a poxvirus protein, VCP, that inhi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00214-8
更新日期:2001-01-26 00:00:00
abstract::Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines and growth factors as therapeutics. Stem cell factor (SCF) is a growth factor that acts throu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.02.011
更新日期:2017-03-09 00:00:00
abstract::Finding the components of cellular circuits and determining their functions systematically remains a major challenge in mammalian cells. Here, we introduced genome-wide pooled CRISPR-Cas9 libraries into dendritic cells (DCs) to identify genes that control the induction of tumor necrosis factor (Tnf) by bacterial lipop...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.06.059
更新日期:2015-07-30 00:00:00
abstract::DNA demethylating agents are approved for some blood malignancies and are under active investigation in solid tumors, but how these drugs work has remained unclear. In this issue of Cell, two groups show that these agents activate a toxic cellular antiviral program through transcriptional activation of endogenous retr...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2015.08.005
更新日期:2015-08-27 00:00:00
abstract::Secretory proteins are segregated from cytosolic proteins by their translocation into the endoplasmic reticulum (ER). A modified secretory protein trapped during translocation across the ER membrane can be crosslinked to two previously identified proteins, Sec61p and BiP (Kar2p). The dependence of this cross-linking u...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90415-9
更新日期:1992-04-17 00:00:00
abstract::Hunger and thirst have distinct goals but control similar ingestive behaviors, and little is known about neural processes that are shared between these behavioral states. We identify glutamatergic neurons in the peri-locus coeruleus (periLCVGLUT2 neurons) as a polysynaptic convergence node from separate energy-sensiti...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.07.031
更新日期:2020-09-17 00:00:00
abstract::An "off-the-shelf" cell therapy derived from induced pluripotent stem cells (iPSCs) has entered clinical trials in the United States. Other companies are following suit, harnessing iPSCs' self-renewal ability to manufacture cell therapies that don't require customization for each patient. But some experts aren't sure ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2019.05.043
更新日期:2019-06-13 00:00:00
abstract::The cis-trans isomerization of proline serves as a regulatory switch in signaling pathways. We identify the proline isomerase Fpr4, a member of the FK506 binding protein family in Saccharomyces cerevisiae, as an enzyme which binds the amino-terminal tail of histones H3 and H4 and catalyses the isomerization of H3 prol...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.07.026
更新日期:2006-09-08 00:00:00
abstract::Erythroid Krüppel-like factor (EKLF) is necessary for stage-specific expression of the human beta-globin gene. We show that EKLF requires a SWI/SNF-related chromatin remodeling complex, EKLF coactivator-remodeling complex 1 (E-RC1), to generate a DNase I hypersensitive, transcriptionally active beta-globin promoter on...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81785-7
更新日期:1998-10-02 00:00:00
abstract::Type I spiral ganglion neurons (SGNs) transmit sound information from cochlear hair cells to the CNS. Using transcriptome analysis of thousands of single neurons, we demonstrate that murine type I SGNs consist of subclasses that are defined by the expression of subsets of transcription factors, cell adhesion molecules...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.07.008
更新日期:2018-08-23 00:00:00
abstract::Expression of human immunodeficiency virus type 1 structural proteins requires both the viral Rev trans-activator and its cis-acting RNA target sequence, the Rev response element (RRE). The RRE has been mapped to a conserved region of the HIV-1 env gene and is predicted to form a complex, highly stable RNA stem-loop s...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90670-a
更新日期:1990-02-23 00:00:00
abstract::The small ribosomal subunit performs the decoding of genetic information during translation. The structure of that from Thermus thermophilus shows that the decoding center, which positions mRNA and three tRNAs, is constructed entirely of RNA. The entrance to the mRNA channel will encircle the message when a latch-like...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)00084-2
更新日期:2000-09-01 00:00:00
abstract::Cyclic dinucleotides (CDNs) have been previously recognized as important secondary signaling molecules in bacteria and, more recently, in mammalian cells. In the former case, they represent secondary messengers affecting numerous responses of the prokaryotic cell, whereas in the latter, they act as agonists of the inn...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2013.08.014
更新日期:2013-08-29 00:00:00
abstract::For many scientific awards, such as Nobels and Laskers, the maximum number of recipients is three. This Rule of Three forces selection committees to make difficult decisions that increase the likelihood of singling out those individuals who open a new field and continue to lead it. The Rule of Three is reminiscent of ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.08.040
更新日期:2016-09-22 00:00:00
abstract::The mitotic checkpoint prevents advance to anaphase prior to successful attachment of every centromere/kinetochore to mitotic spindle microtubules. Using purified components and Xenopus egg extracts, the kinetochore-associated microtubule motor CENP-E is now shown to be the activator of the essential checkpoint kinase...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00475-6
更新日期:2003-07-11 00:00:00
abstract::The general inhibition in transcriptional activity during mitosis abolishes the stress-inducible expression of the human hsp70 gene. Among the four transcription factors that bind to the human hsp70 promoter, the DNA-binding activities of three (C/EBP, GBP, and HSF1) were normal, while Sp1 showed reduced binding activ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90231-7
更新日期:1995-10-06 00:00:00
abstract::Maintaining the pluripotency of mouse ES cells requires both LIF (leukemia inhibitory factor) and unknown factors in serum. The paper from Ying et al. in this issue of Cell shows that BMP (bone morphogenetic protein) can replace serum in this capacity, defining molecular requirements for ES cell self-renewal. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/s0092-8674(03)00853-5
更新日期:2003-10-31 00:00:00
abstract::Pathways that govern stem cell (SC) function are often subverted in cancer. Here, we report the isolation to near purity of human normal mammary SCs (hNMSCs), from cultured mammospheres, on the basis of their ability to retain the lipophilic dye PKH26 as a consequence of their quiescent nature. PKH26-positive cells po...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.12.007
更新日期:2010-01-08 00:00:00
abstract::Proteins, particularly viral proteins, can be multifunctional, but the mechanisms behind multifunctionality are not fully understood. Here, we illustrate through multiple crystal structures, biochemistry, and cellular microscopy that VP40 rearranges into different structures, each with a distinct function required for...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.07.015
更新日期:2013-08-15 00:00:00
abstract::A Drosophila gene with similarity to the mammalian Ras GTPase activating protein has been isolated in screens for mutations that affect eye development. Inactivation of the locus, Gap1, mimics constitutive activation of the Sevenless receptor tyrosine kinase and eliminates the need for a functional Sevenless protein i...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90073-l
更新日期:1992-03-20 00:00:00
abstract::The "holobiont" concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snapshots of the evolvin...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2017.11.024
更新日期:2017-12-14 00:00:00
abstract::Suppressor of Hairless [Su(H)]/Lag-1/RBP-Jkappa/CBF1 is the only known transducing transcription factor for Notch receptor signaling. Here, we show that Su(H) has three distinct functions in the development of external mechanosensory organs in Drosophila: Notch-dependent transcriptional activation and a novel auto-rep...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)00198-7
更新日期:2000-12-08 00:00:00
abstract::While the nuclear lamin proteins (A, B, and C) assemble specifically at the surface of the nuclear membrane, their sequences do not reveal stretches of hydrophobic amino acids that might explain their association with the nuclear membranes. However, the A and B lamin proteins possess Ras-like C-terminal CaaX sequence ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90753-8
更新日期:1989-12-22 00:00:00
abstract::Adenovirus E1B 19 kDa protein protects against cell death induced by viral infection and certain external stimuli. The Bcl-2 protein can functionally substitute for the E1B 19 kDa protein. To identify cellular targets for the 19 kDa protein, we used the two-hybrid screen in yeast. We have isolated cDNAs for three diff...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90202-x
更新日期:1994-10-21 00:00:00
abstract::Dysfunctional mitochondria accumulate in many human diseases. Accordingly, mitophagy, which removes these mitochondria through lysosomal degradation, is attracting broad attention. Due to uncertainties in the operational principles of conventional mitophagy probes, however, the specificity and quantitativeness of thei...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.04.025
更新日期:2020-05-28 00:00:00