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Mutant PTEN in Cancer: Worse Than Nothing.

Abstract：

:Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients with PTEN gene mutations.

journal_name

Cell

journal_title

Cell

authors

Leslie NR,den Hertog J

doi

10.1016/j.cell.2014.04.008

subject

Has Abstract

pub_date

2014-04-24 00:00:00

pages

527-9

issue

3

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(14)00479-6

journal_volume

157

pub_type

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