Abstract：
:The Reelin ligand regulates a Dab1-dependent signaling pathway required for brain lamination and normal dendritogenesis, but the specific mechanisms underlying these actions remain unclear. We find that Stk25, a modifier of Reelin-Dab1 signaling, regulates Golgi morphology and neuronal polarization as part of an LKB1-Stk25-Golgi matrix protein 130 (GM130) signaling pathway. Overexpression of Stk25 induces Golgi condensation and multiple axons, both of which are rescued by Reelin treatment. Reelin stimulation of cultured neurons induces the extension of the Golgi into dendrites, which is suppressed by Stk25 overexpression. In vivo, Reelin and Dab1 are required for the normal extension of the Golgi apparatus into the apical dendrites of hippocampal and neocortical pyramidal neurons. This demonstrates that the balance between Reelin-Dab1 signaling and LKB1-Stk25-GM130 regulates Golgi dispersion, axon specification, and dendrite growth and provides insights into the importance of the Golgi apparatus for cell polarization.
journal_name
Celljournal_title
Cellauthors
Matsuki T,Matthews RT,Cooper JA,van der Brug MP,Cookson MR,Hardy JA,Olson EC,Howell BWdoi
10.1016/j.cell.2010.10.029subject
Has Abstractpub_date
2010-11-24 00:00:00pages
826-36issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(10)01230-4journal_volume
143pub_type
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