Abstract：
:The textbook view of gene activation is that the rate-limiting step is the interaction of RNA polymerase II (Pol II) with the gene's promoter. However, studies in a variety of systems, including human embryonic stem cells and the early Drosophila embryo, have begun to challenge this view. There is increasing evidence that differential gene expression often depends on the regulation of transcription elongation via the release of Pol II from the proximal promoter. I review the implications of this mechanism of gene activation with respect to the orderly unfolding of complex gene networks governing animal development.
journal_name
Celljournal_title
Cellauthors
Levine Mdoi
10.1016/j.cell.2011.04.021subject
Has Abstractpub_date
2011-05-13 00:00:00pages
502-11issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(11)00479-Xjournal_volume
145pub_type
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