Abstract：
:Atopic dermatitis (AD) is a chronic itch and inflammatory disorder of the skin that affects one in ten people. Patients suffering from severe AD eventually progress to develop asthma and allergic rhinitis, in a process known as the "atopic march." Signaling between epithelial cells and innate immune cells via the cytokine thymic stromal lymphopoietin (TSLP) is thought to drive AD and the atopic march. Here, we report that epithelial cells directly communicate to cutaneous sensory neurons via TSLP to promote itch. We identify the ORAI1/NFAT calcium signaling pathway as an essential regulator of TSLP release from keratinocytes, the primary epithelial cells of the skin. TSLP then acts directly on a subset of TRPA1-positive sensory neurons to trigger robust itch behaviors. Our results support a model whereby calcium-dependent TSLP release by keratinocytes activates both primary afferent neurons and immune cells to promote inflammatory responses in the skin and airways.
journal_name
Celljournal_title
Cellauthors
Wilson SR,Thé L,Batia LM,Beattie K,Katibah GE,McClain SP,Pellegrino M,Estandian DM,Bautista DMdoi
10.1016/j.cell.2013.08.057subject
Has Abstractpub_date
2013-10-10 00:00:00pages
285-95issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(13)01088-Xjournal_volume
155pub_type
杂志文章相关文献
CELL文献大全abstract：:Actomyosin retrograde flow underlies the contraction essential for cell motility. Retrograde flow in both lamellipodia and lamella is required for membrane protrusion and for force generation by coupling to cell adhesion. We report that the Rac/Cdc42-binding kinase MRCK and myosin II-related MYO18A linked by the adapt...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.09.018
更新日期：2008-10-03 00:00:00
abstract：:Poly(A)-containing RNA, isolated from rat ventral prostate, has been analyzed for its base sequence complexity. The kinetics of hybridization of total cellular poly(A)-containing RNA with its complementary DNA (cDNA) from normal and castrated animals are markedly different. RNA from normal animals consists of three ab...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(77)90116-7
更新日期：1977-10-01 00:00:00
abstract：:Prions, self-propagating protein structures that can be transmitted between cells and different organisms, usually consist of ordered protein aggregates. Alberti et al. (2009) now present a systematic approach for the discovery of new prions that expands the spectrum of their biological functions. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2009.03.030
更新日期：2009-04-03 00:00:00
abstract：:The mesenchymal-amoeboid transition (MAT) was proposed as a mechanism for cancer cells to adapt their migration mode to their environment. While the molecular pathways involved in this transition are well documented, the role of the microenvironment in the MAT is still poorly understood. Here, we investigated how conf...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.01.007
更新日期：2015-02-12 00:00:00
abstract：:In a culture system where a bifurcated Aplysia sensory neuron makes synapses with two motor neurons, repeated application of serotonin (5-HT) to one synapse produces a CREB-mediated, synapse-specific, long-term facilitation, which can be captured at the opposite synapse by a single pulse of 5-HT. Repeated pulses of 5-...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81653-0
更新日期：1999-10-15 00:00:00
abstract：:Viable yet damaged cells can accumulate during development and aging. Although eliminating those cells may benefit organ function, identification of this less fit cell population remains challenging. Previously, we identified a molecular mechanism, based on "fitness fingerprints" displayed on cell membranes, which all...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.12.017
更新日期：2015-01-29 00:00:00
abstract：:We have developed an in vitro system utilizing yeast cell-free extracts to catalyze recombination events between homologous plasmids containing different mutant alleles of the Tet or ARG4 genes. The reaction increased the frequency of Tcr or Arg+ transformants (recombinants) from 2 X 10(-6) to 1-3 X 10(-3). Linearizin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90113-7
更新日期：1983-12-01 00:00:00
abstract：:A recent series of papers, including Festa et al. (2011) in this issue, has revealed unexpected interdependent relationships among cell populations residing in and around the hair follicle. These interactions between different lineages of stem cells are crucial for hair follicle growth and cycling and point to a compl...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2011.08.020
更新日期：2011-09-02 00:00:00
abstract：:The erythropoietin receptor (EpoR) is essential for production of red blood cells; a principal function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly activated following EpoR stimulation, but its function in erythropoiesis has been unclear since adult Stat5a-/-5b-/- mice have no...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81013-2
更新日期：1999-07-23 00:00:00
abstract：:We have investigated RNA recombination among poliovirus genomes by analyzing both intratypic and intertypic recombinant crosses involving the same defined genetic markers. Sequence analysis of the recombinant junctions of 13 nonsibling intertypic recombinants showed that intertypic RNA recombination is not site-specif...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90600-8
更新日期：1986-11-07 00:00:00
abstract：:Chromosomal translocations between antigen receptor loci and oncogenes are a hallmark of lymphoid cancers. Several new studies now reveal that programmed DNA breaks created during assembly of antigen receptor genes can be channeled into an alternative DNA end-joining pathway that is implicated in the chromosomal trans...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.10.005
更新日期：2007-10-19 00:00:00
abstract：:The function of somatic stem cells declines with age. Understanding the molecular underpinnings of this decline is key to counteract age-related disease. Here, we report a dramatic drop in the neural stem cells (NSCs) number in the aging murine brain. We find that this smaller stem cell reservoir is protected from ful...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.01.040
更新日期：2019-03-07 00:00:00
abstract：:I have identified an activity in crude HeLa cell extracts that satisfies the requirements for a human telomere terminal transferase or telomerase. It catalyzes the addition of a 6 nucleotide repeating pattern to oligonucleotide primers containing human or nonhuman telomeric repeat sequences. Direct sequence analyses o...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90035-4
更新日期：1989-11-03 00:00:00
abstract：:N(6)-methyladenosine (m(6)A) is the most abundant internal modification of messenger RNA. While the presence of m(6)A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates processing of nuclear transcripts has not been identified. We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-be...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.08.011
更新日期：2015-09-10 00:00:00
abstract：:The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of "orphan" T cell receptors (TCRs) expressed on TILs from h...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.11.043
更新日期：2018-01-25 00:00:00
abstract：:Motor neurons stimulate their postsynaptic muscle targets to synthesize neurotransmitter receptors. Polypeptide signaling molecules may mediate this inductive interaction. Here we report the purification of ARIA, a protein that stimulates the synthesis of muscle acetylcholine receptors, and the isolation of ARIA cDNA....
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90407-h
更新日期：1993-03-12 00:00:00
abstract：:Nerve regeneration and developmental outgrowth of axons are both correlated with increased synthesis of an axonal membrane protein designated GAP-43. Phosphorylation of an apparently identical protein, present at lower abundance in adult brains, has been correlated with long-term potentiation, a form of synaptic plast...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90616-7
更新日期：1987-06-19 00:00:00
abstract：:Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines and growth factors as therapeutics. Stem cell factor (SCF) is a growth factor that acts throu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.02.011
更新日期：2017-03-09 00:00:00
abstract：:Transcriptional pausing by multisubunit RNA polymerases (RNAPs) is a key mechanism for regulating gene expression in both prokaryotes and eukaryotes and is a prerequisite for transcription termination. Pausing and termination states are thought to arise through a common, elemental pause state that is inhibitory for nu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.12.020
更新日期：2013-01-31 00:00:00
abstract：:To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase reactivation in the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.12.028
更新日期：2012-02-17 00:00:00
abstract：:The transmembrane ligand ephrinB2 and its cognate Eph receptor tyrosine kinases are important regulators of vascular morphogenesis. EphrinB2 may have an active signaling role, resulting in bi-directional signal transduction downstream of both ephrinB2 and Eph receptors. To separate the ligand and receptor-like functio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00191-x
更新日期：2001-01-12 00:00:00
abstract：:Bacteria and archaea have evolved sophisticated adaptive immune systems that reply on CRISPR loci and a diverse cassette of Cas genes that are classified into three main types and at least eleven subtypes. All CRISPR-Cas immune systems operate through three main stages: acquisition, biogenesis, and interference. This ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.09.011
更新日期：2015-09-24 00:00:00
abstract：:The human La antigen is an RNA-binding protein that facilitates transcriptional termination and reinitiation by RNA polymerase III. Native La protein fractionates into transcriptionally active and inactive forms that are unphosphorylated and phosphorylated at serine 366, respectively, as determined by enzymatic and ma...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81913-3
更新日期：1997-03-07 00:00:00
abstract：:RNAs fold into defined tertiary structures to function in critical biological processes. While quantitative models can predict RNA secondary structure stability, we are still unable to predict the thermodynamic stability of RNA tertiary structure. Here, we probe conformational preferences of diverse RNA two-way juncti...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.05.038
更新日期：2018-07-12 00:00:00
abstract：:Rapid flow of information in the nervous system involves presynaptic vesicle recycling by clathrin-mediated endocytosis, an event triggered by the alpha-adaptin-containing AP2 complex. We identified a Drosophila alpha-adaptin expressed in the garland cells, imaginal discs, and the CNS. Here we show its role in presyna...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81923-6
更新日期：1997-03-21 00:00:00
abstract：:The larval salivary glands of Drosophila melanogaster, which are widely used for cytogenic studies, are also useful for studying the regulation of specific protein synthesis during differentiation. These glands synthesize and secrete massive amounts of a glue which attaches the pupae to the substrate during metamorpho...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90081-7
更新日期：1976-11-01 00:00:00
abstract：:Syntaxin 1A plays a central role in neurotransmitter release through multiple protein-protein interactions. We have used NMR spectroscopy to identify an autonomously folded N-terminal domain in syntaxin 1A and to elucidate its three-dimensional structure. This 120-residue N-terminal domain is conserved in plasma membr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81742-0
更新日期：1998-09-18 00:00:00
abstract：:Cytoplasmic dynein is a motor protein that exerts force on microtubules. To generate force for the movement of large organelles, dynein needs to be anchored, with the anchoring sites being typically located at the cell cortex. However, the mechanism by which dyneins target sites where they can generate large collectiv...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.05.020
更新日期：2013-06-20 00:00:00
abstract：:Oligodendrocyte-specific protein (OSP)/claudin-11 is a recently identified transmembrane protein found in CNS myelin and testis with unknown function. Herein we demonstrate that Osp null mice exhibit both neurological and reproductive deficits: CNS nerve conduction is slowed, hindlimb weakness is conspicuous, and male...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81553-6
更新日期：1999-12-10 00:00:00
abstract：:The mitotic checkpoint ensures proper chromosome segregation by delaying anaphase until chromosomes are aligned on the spindle. Following prolonged spindle damage, however, cells eventually exit mitosis and undergo apoptosis. We show here that a murine homolog of the yeast mitotic checkpoint gene BUB1 localizes to the...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80255-x
更新日期：1997-05-30 00:00:00
