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Fetal anemia and apoptosis of red cell progenitors in Stat5a-/-5b-/- mice: a direct role for Stat5 in Bcl-X(L) induction.

Abstract：

:The erythropoietin receptor (EpoR) is essential for production of red blood cells; a principal function of EpoR is to rescue committed erythroid progenitors from apoptosis. Stat5 is rapidly activated following EpoR stimulation, but its function in erythropoiesis has been unclear since adult Stat5a-/-5b-/- mice have normal steady-state hematocrit. Here we show that Stat5 is essential for the high erythropoietic rate during fetal development. Stat5a-/-5b-/- embryos are severely anemic; erythroid progenitors are present in low numbers, show higher levels of apoptosis, and are less responsive to Epo. These findings are explained by a crucial role for Stat5 in EpoR's antiapoptotic signaling: it mediates the immediate-early induction of Bcl-X(L) in erythroid cells through direct binding to the Bcl-X promoter.

journal_name

Cell

journal_title

Cell

authors

Socolovsky M,Fallon AE,Wang S,Brugnara C,Lodish HF

doi

10.1016/s0092-8674(00)81013-2

subject

Has Abstract

pub_date

1999-07-23 00:00:00

pages

181-91

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(00)81013-2

journal_volume

98

pub_type

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