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Single-Cell Analysis: The Differences That Kill.

Abstract：

:Using single-cell RNA sequencing, Avraham et al. investigate how variability in macrophage response to infection is controlled by variability within the pathogen population. They find that heterogeneous expression of the Salmonella virulence factor PhoP and subsequent cell-wall modifications lead to the bimodal induction of the interferon-response in infected macrophages.

journal_name

Cell

journal_title

Cell

authors

Tay S

doi

10.1016/j.cell.2015.08.053

subject

Has Abstract

pub_date

2015-09-10 00:00:00

pages

1208-10

issue

6

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(15)01105-8

journal_volume

162

pub_type

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