Abstract：
:Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA downregulation is a common trait of human malignancies. The mechanisms of this phenomenon and the advantages it affords remain poorly understood. Here we identify a microRNA family, miR-103/107, that attenuates miRNA biosynthesis by targeting Dicer, a key component of the miRNA processing machinery. In human breast cancer, high levels of miR-103/107 are associated with metastasis and poor outcome. Functionally, miR-103/107 confer migratory capacities in vitro and empower metastatic dissemination of otherwise nonaggressive cells in vivo. Inhibition of miR-103/107 opposes migration and metastasis of malignant cells. At the cellular level, a key event fostered by miR-103/107 is induction of epithelial-to-mesenchymal transition (EMT), attained by downregulating miR-200 levels. These findings suggest a new pathway by which Dicer inhibition drifts epithelial cancer toward a less-differentiated, mesenchymal fate to foster metastasis.
journal_name
Celljournal_title
Cellauthors
Martello G,Rosato A,Ferrari F,Manfrin A,Cordenonsi M,Dupont S,Enzo E,Guzzardo V,Rondina M,Spruce T,Parenti AR,Daidone MG,Bicciato S,Piccolo Sdoi
10.1016/j.cell.2010.05.017subject
Has Abstractpub_date
2010-06-25 00:00:00pages
1195-207issue
7eissn
0092-8674issn
1097-4172pii
S0092-8674(10)00553-2journal_volume
141pub_type
杂志文章相关文献
CELL文献大全abstract：:Peptide growth factors may play a role in patterning of the early embryo, particularly in the induction of mesoderm. We have explored the role of fibroblast growth factor (FGF) in early Xenopus development by expressing a dominant negative mutant form of the FGF receptor. Using a functional assay in frog oocytes, we f...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90616-7
更新日期：1991-07-26 00:00:00
abstract：:The single most frequent cancer-causing mutation across all heterotrimeric G proteins is R201C in Gαs. The current model explaining the gain-of-function activity of the R201 mutations is through the loss of GTPase activity and resulting inability to switch off to the GDP state. Here, we find that the R201C mutation ca...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.03.018
更新日期：2018-05-17 00:00:00
abstract：:In this issue, Frey and Görlich (2007) provide new insight into the selective barrier that controls protein traffic through the nuclear pore complex. They show that a single protein domain of the nuclear pore protein Nsp1 can form a hydrogel that allows highly selective access of nuclear transport receptors and their ...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2007.07.029
更新日期：2007-08-10 00:00:00
abstract：:DNA carrying inverted repeats was tested for transposition within the Drosophila genome. Five Bam HI segments containing related inverted repeats were isolated from D. melanogaster and analyzed by electron microscopy and restriction mapping. Southern blot experiments using single-copy flanking sequences as probes allo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90310-4
更新日期：1980-07-01 00:00:00
abstract：:Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTE...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.09.033
更新日期：2015-10-08 00:00:00
abstract：:Solute carrier (SLC) membrane transport proteins control essential physiological functions, including nutrient uptake, ion transport, and waste removal. SLCs interact with several important drugs, and a quarter of the more than 400 SLC genes are associated with human diseases. Yet, compared to other gene families of s...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2015.07.022
更新日期：2015-07-30 00:00:00
abstract：:Alterations of symbiosis between microbiota and intestinal epithelial cells (IEC) are associated with intestinal and systemic pathologies. Interactions between bacterial products (MAMPs) and Toll-like receptors (TLRs) are known to be mandatory for IEC homeostasis, but how TLRs may time homeostatic functions with circa...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.04.020
更新日期：2013-05-09 00:00:00
abstract：:Cyclic dinucleotides (CDNs) play central roles in bacterial pathogenesis and innate immunity. The mammalian enzyme cGAS synthesizes a unique cyclic dinucleotide (cGAMP) containing a 2'-5' phosphodiester linkage essential for optimal immune stimulation, but the molecular basis for linkage specificity is unknown. Here, ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.07.028
更新日期：2014-08-28 00:00:00
abstract：:Based on the above mechanisms of mRNA degradation, an integrated model of mRNA turnover can be proposed (Figure 1). In this model, all polyadenylated mRNAs would be degraded by the deadenylation-dependent pathway at some rate. In addition to this default pathway, another layer of complexity would come from degradation...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/0092-8674(95)90326-7
更新日期：1995-04-21 00:00:00
abstract：:We examine the interaction between polyoma-virus-encoded middle tumor antigen and the cellular src gene product, pp60c-src, using a series of monoclonal antibodies that recognize mammalian pp60c-src. Our results show that infection of mouse cells with transformation-competent strains of polyoma virus results in the st...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90272-1
更新日期：1984-10-01 00:00:00
abstract：:The central vasculature of plant roots is protected by a hydrophobic ring of endodermal cells that are enclosed by lamellae of suberin. Barberon et al. demonstrate that endodermal suberization plasticity facilitates ion homeostasis, with antithetical regulation of suberin deposition and degradation by the phytohormone...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.01.005
更新日期：2016-01-28 00:00:00
abstract：:Homology is an important feature of recombination. We have used the rll cistrons of bacteriophage T4 to determine the extent of homology required for recombination. We varied the amount of homologous DNA available for recombination in both marker rescue experiments and deletion-by-deletion crosses. Our results suggest...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90401-9
更新日期：1982-11-01 00:00:00
abstract：:In order for telomeres to remain functional and stable, they must rendezvous with the enzyme telomerase in a productive manner. In human cells, this interaction is mediated by Cajal bodies as matchmaker, and now Zhong et al. reveal molecular determinants that establish good chemistry between the two partners. ...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.07.015
更新日期：2012-08-03 00:00:00
abstract：:The archetypal human tumor suppressor p53 is considered to have unique transactivation properties. The assumption is based on the fact that additionally identified human p53 isoforms lack transcriptional activity. However, we provide evidence for the existence of an alternatively spliced p53 isoform (Deltap53) that ex...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.04.032
更新日期：2005-07-15 00:00:00
abstract：:The mammalian alpha- and beta--globin genes are thought to have evolved from a common ancestral sequence by a duplication event that occurred over 500 million years ago. We have now determined the entire nucleotide sequence of a cloned mouse alpha--globin gene, including regions that flank and interrupt the coding seq...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90139-9
更新日期：1979-11-01 00:00:00
abstract：:AMPA receptors mediate fast excitatory neurotransmission in the mammalian brain and transduce the binding of presynaptically released glutamate to the opening of a transmembrane cation channel. Within the postsynaptic density, however, AMPA receptors coassemble with transmembrane AMPA receptor regulatory proteins (TAR...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.07.045
更新日期：2017-09-07 00:00:00
abstract：:We have analyzed the viral DNA sequences persisting in HE C19, a clonal line of hamster embryo cells transformed in vitro by human adenovirus 12 (Ad 12), a member of highly oncogenic group A. Saturation-hybridization of in vitro labeled Ad 12 DNA (2-4 x 10(8) cpm/mug) with HE C19 DNA showed that 93-100% of viral DNA s...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90172-0
更新日期：1976-03-01 00:00:00
abstract：:KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.01.006
更新日期：2018-01-25 00:00:00
abstract：:In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell "macrolesions" are characteristically pro-inflammatory, resident macrophages can "cloak" single-cell micro...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2019.03.042
更新日期：2019-04-18 00:00:00
abstract：:PTEN is a frequently mutated tumor suppressor gene that opposes the PI3K/AKT pathway through dephosphorylation of phosphoinositide-3,4,5-triphosphate. Recently, nuclear compartmentalization of PTEN was found as a key component of its tumor-suppressive activity; however its nuclear function remains poorly defined. Here...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.12.020
更新日期：2011-01-21 00:00:00
abstract：:Endoplasmic reticulum (ER) membrane contact sites (MCSs) mark positions where endosomes undergo fission for cargo sorting. To define the role of ER at this unique MCS, we targeted a promiscuous biotin ligase to cargo-sorting domains on endosome buds. This strategy identified the ER membrane protein TMCC1, a member of ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.08.030
更新日期：2018-09-20 00:00:00
abstract：:The eukaryotic 20S proteasome is known to associate with the IFN gamma-inducible regulator PA28. We analyzed the kinetics of product generation by 20S proteasomes with and without PA28. In the absence of PA28, the 20S proteasome rapidly generates peptides that have been cleaved only once, while internal fragments accu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80097-5
更新日期：1996-07-26 00:00:00
abstract：:Cytotoxic brain edema triggered by neuronal swelling is the chief cause of mortality following brain trauma and cerebral infarct. Using fluorescence lifetime imaging to analyze contributions of intracellular ionic changes in brain slices, we find that intense Na(+) entry triggers a secondary increase in intracellular ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.03.029
更新日期：2015-04-23 00:00:00
abstract：:The germinal center (GC) reaction produces high-affinity antibodies by random mutation and selective clonal expansion of B cells with high-affinity receptors. The mechanism by which B cells are selected remains unclear, as does the role of the two anatomically defined areas of the GC, light zone (LZ) and dark zone (DZ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.10.032
更新日期：2010-11-12 00:00:00
abstract：:Chronic viral infections represent a major burden to human health, and modulation of the immune system is emerging as a novel approach to fighting such infections. Pellegrini et al. (2011) demonstrate that treatment with the cytokine IL-7 may reinvigorate the immune response to persistent infection by targeting immuno...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2011.01.038
更新日期：2011-02-18 00:00:00
abstract：:5, 6-dichloro-1-beta-D-ribofuranosylbenzimidazole (DRB; 75 muM) inhibited only 60-75% of nuclear heterogeneous RNA (hnRNA) synthesis in HeLa cells, while the appearance of labeled cytoplasmic poly(A)-containing messenger RNA (mRNA) was reduced by approximately 95%. DRB-sensitive and resistant transcripts spanned the e...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90092-1
更新日期：1976-11-01 00:00:00
abstract：:The Rho family of GTPases control diverse biological processes, including cell morphology and mitogenesis. We have identified WASP, the protein that is defective in Wiskott-Aldrich syndrome (WAS), as a novel effector for CDC42Hs, but not for the other Rho family members, Rac and Rho. This interaction is dependent on t...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81050-8
更新日期：1996-03-08 00:00:00
abstract：:A recombinant peptide encoding the CD11b A domain bound 54Mn2+ with a high affinity. Other divalent cations, including Mg2+, Zn2+, Ni2+, Co2+, and Cd2+, but not Ca2+ or Ba2+, competed effectively for Mn2+ binding. Amino acid substitutions within two conserved and noncontiguous regions in the recombinant peptide abolis...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90575-b
更新日期：1993-03-26 00:00:00
abstract：:Huntington's disease (HD) is an incurable neuropsychiatric disease associated with CAG repeat expansion within a widely expressed gene that causes selective neuronal death. To understand its normal function, we have created a targeted disruption in exon 5 of Hdh (Hdhex5), the murine homolog of the HD gene. Homozygotes...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90542-1
更新日期：1995-06-02 00:00:00
abstract：:The mechanism by which MPF induces nuclear lamin disassembly and nuclear envelope breakdown during mitosis was studied in a frog egg extract in which the transition from interphase to mitosis can be induced by the addition of MPF. Bacterially expressed human nuclear lamin C, assembled in vitro into filaments, showed i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90469-u
更新日期：1990-05-18 00:00:00
