A unique pattern of integrated viral genes in hamster cells transformed by highly oncogenic human adenovirus 12.

abstract：:The full-length cDNA for a transcriptional activator, DBP, that binds to the D site of the albumin promoter has been cloned. DBP belongs to a family of related transcription factors including Fos, Jun, CREB, and C/EBP, which share a conserved basic domain. However, unlike most other members of this family, DBP does no...

journal_title：Cell

authors： Mueller CR,Maire P,Schibler U

更新日期：1990-04-20 00:00:00

abstract：:We have identified in mice an allele of a new T cell receptor V beta gene, V beta 17a, whose product is bound by the monoclonal antibody KJ23a. Over 90% of T cell hybridomas prepared from V beta 17a+ T cells of SWR mice respond to allogeneic forms of the IE class II MHC protein, indicating that V beta 17a has an appre...

journal_title：Cell

authors： Kappler JW,Wade T,White J,Kushnir E,Blackman M,Bill J,Roehm N,Marrack P

更新日期：1987-04-24 00:00:00

abstract：:The origin of a low molecular weight virus-associated RNA (VA-RNA) was mapped by hybridization of VA-RNA to specific fragments of adenovirus type 2 DNA, obtained after cleavage with three different restriction endonucleases. VA-RNA was found to hybridize exculsively to the l-strand [strand with low buoyant density in ...

journal_title：Cell

authors： Pettersson U,Philipson L

更新日期：1975-09-01 00:00:00

abstract：:In C. elegans, removing the germ cells extends life span by triggering the nuclear localization and activation of the DAF-16/FOXO transcription factor in the intestine. In this study, we identify and analyze genes required for germline removal to extend life span. We find that the reproductive system communicates with...

journal_title：Cell

authors： Berman JR,Kenyon C

更新日期：2006-03-10 00:00:00

abstract：:The 90S pre-ribosome is an early biogenesis intermediate formed during co-transcriptional ribosome formation, composed of ∼70 assembly factors and several small nucleolar RNAs (snoRNAs) that associate with nascent pre-rRNA. We report the cryo-EM structure of the Chaetomium thermophilum 90S pre-ribosome, revealing how ...

journal_title：Cell

authors： Kornprobst M,Turk M,Kellner N,Cheng J,Flemming D,Koš-Braun I,Koš M,Thoms M,Berninghausen O,Beckmann R,Hurt E

更新日期：2016-07-14 00:00:00

abstract：:The JAK/STAT signaling pathway, renowned for its effects on cell proliferation and survival, is constitutively active in various human cancers, including ovarian. We have found that JAK and STAT are required to convert the border cells in the Drosophila ovary from stationary, epithelial cells to migratory, invasive ce...

journal_title：Cell

authors： Silver DL,Montell DJ

更新日期：2001-12-28 00:00:00

abstract：:The gut epithelium self-renews every several days, providing an important innate defense system that limits bacterial colonization. Nevertheless, many bacterial pathogens, including Shigella, efficiently colonize the intestinal epithelium. Here, we show that the Shigella effector IpaB, when delivered into epithelial c...

journal_title：Cell

authors： Iwai H,Kim M,Yoshikawa Y,Ashida H,Ogawa M,Fujita Y,Muller D,Kirikae T,Jackson PK,Kotani S,Sasakawa C

更新日期：2007-08-24 00:00:00

abstract：:KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP ...

journal_title：Cell

authors： Janes MR,Zhang J,Li LS,Hansen R,Peters U,Guo X,Chen Y,Babbar A,Firdaus SJ,Darjania L,Feng J,Chen JH,Li S,Li S,Long YO,Thach C,Liu Y,Zarieh A,Ely T,Kucharski JM,Kessler LV,Wu T,Yu K,Wang Y,Yao Y,Deng X,

更新日期：2018-01-25 00:00:00

abstract：:We have localized the regulatory sequence required for viral or poly(I)-poly(C) activation of human beta-interferon gene expression to a region located between -37 and -77 from the mRNA cap site. This sequence has the characteristics of an inducible enhancer element: it can act upstream or downstream of the beta-inter...

journal_title：Cell

authors： Goodbourn S,Zinn K,Maniatis T

更新日期：1985-06-01 00:00:00

abstract：:Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur, just as the theory of gravitation allows one to understand why cannonballs fly in parabolic arcs. The simplest examples of the eukaryotic ce...

journal_title：Cell

authors： Ferrell JE Jr,Tsai TY,Yang Q

更新日期：2011-03-18 00:00:00

abstract：:We have isolated three alleles of a novel Drosophila clock gene, double-time (dbt). Short- (dbtS) and long-period (dbtL) mutants alter both behavioral rhythmicity and molecular oscillations from previously identified clock genes, period and timeless. A third allele, dbtP, causes pupal lethality and eliminates circadia...

journal_title：Cell

authors： Price JL,Blau J,Rothenfluh A,Abodeely M,Kloss B,Young MW

更新日期：1998-07-10 00:00:00

abstract：:Huntington's disease (HD) is an incurable neuropsychiatric disease associated with CAG repeat expansion within a widely expressed gene that causes selective neuronal death. To understand its normal function, we have created a targeted disruption in exon 5 of Hdh (Hdhex5), the murine homolog of the HD gene. Homozygotes...

journal_title：Cell

authors： Nasir J,Floresco SB,O'Kusky JR,Diewert VM,Richman JM,Zeisler J,Borowski A,Marth JD,Phillips AG,Hayden MR

更新日期：1995-06-02 00:00:00

abstract：:A major problem in treatment of cancers arising in steroid-sensitive cells is their inevitable progression to a steroid-insensitive state; current therapies are based on the assumption that hormone insensitivity is associated with loss of receptor. We demonstrate for the first time that breast tumor cells can progress...

journal_title：Cell

authors： Darbre PD,King RJ

更新日期：1987-11-20 00:00:00

abstract：:sigma(70) subunit is thought to be released from the core RNA polymerase (RNAP) upon the transition from initiation to elongation or shortly afterward. Here, we identify a population of RNAP from E. coli that retains sigma(70) throughout elongation. The relative amount of this population appears to depend on cellular ...

journal_title：Cell

authors： Bar-Nahum G,Nudler E

更新日期：2001-08-24 00:00:00

abstract：:Production of nerve growth factor (NGF) was assessed in cultures of human T and B lymphocytes and macrophages. NGF was constitutively produced by B cells only, which also expressed surface p140trk-A and p75NGFR molecules and hence efficiently bound and internalized the cytokine. Neutralization of endogenous NGF caused...

journal_title：Cell

authors： Torcia M,Bracci-Laudiero L,Lucibello M,Nencioni L,Labardi D,Rubartelli A,Cozzolino F,Aloe L,Garaci E

更新日期：1996-05-03 00:00:00

abstract：:The differentiation of body-wall muscle cells was studied in the nematode Caenorhabditis elegans. Specific antibodies to myosin and paramyosin, major protein constituents of differentiated muscle, react with mesodermal cells in wild-type embryos towards the end of the first half of embryogenesis. Immunoreactive cells ...

journal_title：Cell

authors： Gossett LA,Hecht RM,Epstein HF

更新日期：1982-08-01 00:00:00

abstract：:The bHLH-ZIP protein Mad heterodimerizes with Max as a sequence-specific transcriptional repressor. Mad is rapidly induced upon differentiation, and the associated switch from Myc-Max to Mad-Max heterocomplexes seem to repress genes normally activated by Myc-Max. We have identified two related mammalian cDNAs that enc...

journal_title：Cell

authors： Ayer DE,Lawrence QA,Eisenman RN

更新日期：1995-03-10 00:00:00

abstract：:Most mutations in cancer genomes are thought to be acquired after the initiating event, which may cause genomic instability and drive clonal evolution. However, for acute myeloid leukemia (AML), normal karyotypes are common, and genomic instability is unusual. To better understand clonal evolution in AML, we sequenced...

journal_title：Cell

authors： Welch JS,Ley TJ,Link DC,Miller CA,Larson DE,Koboldt DC,Wartman LD,Lamprecht TL,Liu F,Xia J,Kandoth C,Fulton RS,McLellan MD,Dooling DJ,Wallis JW,Chen K,Harris CC,Schmidt HK,Kalicki-Veizer JM,Lu C,Zhang Q,Lin L,

更新日期：2012-07-20 00:00:00

abstract：:Post-translational modification of tubulin offers a mechanism for functional diversification of microtubules and regulation in a variety of physiological contexts. This SnapShot recaps the current state of understanding of tubulin posttranslational modifications and their functions in the regulation of biological proc...

journal_title：Cell

authors： Magiera MM,Singh P,Janke C

更新日期：2018-05-31 00:00:00

abstract：:MicroRNAs interact with Argonaute proteins to guide posttranscriptional gene silencing. Eiring et al. (2010) now show that miR-328 has a second function, acting as a decoy by binding to hnRNP E2 and lifting its translational repression of an mRNA involved in myeloid cell differentiation. ...

journal_title：Cell

authors： Beitzinger M,Meister G

更新日期：2010-03-05 00:00:00

abstract：:The yeast Sir2/3/4p complex is found in abundance at telomeres, where it participates in the formation of silent heterochromatin and telomere maintenance. Here, we show that Sir3p is released from telomeres in response to DNA double-strand breaks (DSBs), binds to DSBs, and mediates their repair, independent of cell ma...

journal_title：Cell

authors： Mills KD,Sinclair DA,Guarente L

更新日期：1999-05-28 00:00:00

abstract：:Our previous deletion experiments have shown that a short region of yeast nuclear gene introns containing the conserved sequence 5'-TACTAACA-3' is essential for splicing. In this report we show that the chemically synthesized decanucleotide 5'-TGTACTAACA-3', when introduced into a hybrid gene forming unspliceable RNA ...

journal_title：Cell

authors： Langford CJ,Klinz FJ,Donath C,Gallwitz D

更新日期：1984-03-01 00:00:00

abstract：:AMPA-type glutamate receptors (AMPA-Rs) mediate a majority of excitatory synaptic transmission in the brain. In hippocampus, most AMPA-Rs are hetero-oligomers composed of GluR1/GluR2 or GluR2/GluR3 subunits. Here we show that these AMPA-R forms display different synaptic delivery mechanisms. GluR1/GluR2 receptors are ...

journal_title：Cell

authors： Shi S,Hayashi Y,Esteban JA,Malinow R

更新日期：2001-05-04 00:00:00

abstract：:Previous work from our laboratory has demonstrated that a subclass of the aminoglycoside antibiotics, those containing the drug fragment paromamine, stimulates mistranslation in cell-free protein-synthesizing systems derived from eucaryotic cells. We report here experiments which show that the ciliate Tetrahymena ther...

journal_title：Cell

authors： Palmer E,Wilhelm JM

更新日期：1978-02-01 00:00:00

abstract：:Glial cells are essential components of the nervous system. In this issue, Singhvi et al. uncover cellular and molecular mechanisms through which C. elegans glia shape sensory neuron terminals and thus control animal thermosensing behaviors. ...

journal_title：Cell

authors： Sun LO,Barres BA

更新日期：2016-05-05 00:00:00

abstract：:Leukocyte adhesion deficiency (LAD) is a heritable disease involving deficient expression of three related leukocyte adhesion glycoproteins: LFA-1, Mac-1, and p150,95. These proteins are alpha beta heterodimers containing identical 95,000 dalton beta subunits. Here we demonstrate that the primary defect in LAD is in t...

journal_title：Cell

authors： Kishimoto TK,Hollander N,Roberts TM,Anderson DC,Springer TA

更新日期：1987-07-17 00:00:00

abstract：:PD-1 immune checkpoint blockade provides significant clinical benefits for melanoma patients. We analyzed the somatic mutanomes and transcriptomes of pretreatment melanoma biopsies to identify factors that may influence innate sensitivity or resistance to anti-PD-1 therapy. We find that overall high mutational loads a...

journal_title：Cell

authors： Hugo W,Zaretsky JM,Sun L,Song C,Moreno BH,Hu-Lieskovan S,Berent-Maoz B,Pang J,Chmielowski B,Cherry G,Seja E,Lomeli S,Kong X,Kelley MC,Sosman JA,Johnson DB,Ribas A,Lo RS

更新日期：2016-03-24 00:00:00

abstract：:Advances in genomic technology have produced an explosion of new information about the genetic basis for human disease, fueling extraordinarily high expectations for improved treatments. This perspective will take brief stock of what genetics/genomics have brought to clinical practice to date and what we might expect ...

journal_title：Cell

authors： Ginsburg D

更新日期：2011-09-30 00:00:00

abstract：:Four RNA products have been characterized from a soluble system that accurately splices purified substrate RNA. The labeled substrate RNA contained the first and second exons of the major late transcription unit of adenovirus 2 and a shortened form of the first intervening sequence. One of these RNA products was the e...

journal_title：Cell

authors： Grabowski PJ,Padgett RA,Sharp PA

更新日期：1984-06-01 00:00:00

abstract：:The HIV-1 matrix (MA) protein contains two subcellular localization signals with opposing effects. A myristoylated N-terminus governs particle assembly at the plasma membrane, and a nucleophilic motif facilitates import of the viral preintegration complex into the nucleus of nondividing cells. Here, we show that myris...

journal_title：Cell

authors： Gallay P,Swingler S,Aiken C,Trono D

更新日期：1995-02-10 00:00:00