Abstract：
:We have localized the regulatory sequence required for viral or poly(I)-poly(C) activation of human beta-interferon gene expression to a region located between -37 and -77 from the mRNA cap site. This sequence has the characteristics of an inducible enhancer element: it can act upstream or downstream of the beta-interferon gene regardless of its orientation, and at distances up to approximately 1 kilobase from its normal location. Moreover, this element can confer inducibility on a heterologous promoter. Further analysis has identified a minimal regulatory element of 14 base pairs within this enhancer. Sequences closely related to this element are present five times within the 5'-flanking regions of both the alpha- and beta-interferon genes. The number of these minimal regulatory elements required for maximal beta-interferon gene expression appears to differ in different cell lines.
journal_name
Celljournal_title
Cellauthors
Goodbourn S,Zinn K,Maniatis Tdoi
10.1016/s0092-8674(85)80024-6subject
Has Abstractpub_date
1985-06-01 00:00:00pages
509-20issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(85)80024-6journal_volume
41pub_type
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