Abstract：
:The differentiation of body-wall muscle cells was studied in the nematode Caenorhabditis elegans. Specific antibodies to myosin and paramyosin, major protein constituents of differentiated muscle, react with mesodermal cells in wild-type embryos towards the end of the first half of embryogenesis. Immunoreactive cells (2-16) first appear in embryos with 400-450 of the 550 cells present at hatching. Such embryos have developed at 25.5 degrees C for 4-4 1/2 hr beyond the two-cell stage. As development proceeds, a maximum of 81 immunoreactive cells forms four columns running anterior-posterior. Each column is composed of two lines of tightly opposed round cells, which then elongate into spindle-shaped cells. Mutant embryos in which cleavage arrests prematurely also generate cells that produce myosin and paramyosin. The initiation of muscle differentiation appears to be independent of the number of cell or nuclear divisions within a lineage or of the proliferation of other cells. These results suggest that the biosynthesis of muscle-specific proteins by nematode embryonic muscle cells is regulated by mechanisms intrinsic to these cells.
journal_name
Celljournal_title
Cellauthors
Gossett LA,Hecht RM,Epstein HFdoi
10.1016/0092-8674(82)90025-3subject
Has Abstractpub_date
1982-08-01 00:00:00pages
193-204issue
1eissn
0092-8674issn
1097-4172pii
0092-8674(82)90025-3journal_volume
30pub_type
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