Abstract：
:Determining protein levels in each tissue and how they compare with RNA levels is important for understanding human biology and disease as well as regulatory processes that control protein levels. We quantified the relative protein levels from over 12,000 genes across 32 normal human tissues. Tissue-specific or tissue-enriched proteins were identified and compared to transcriptome data. Many ubiquitous transcripts are found to encode tissue-specific proteins. Discordance of RNA and protein enrichment revealed potential sites of synthesis and action of secreted proteins. The tissue-specific distribution of proteins also provides an in-depth view of complex biological events that require the interplay of multiple tissues. Most importantly, our study demonstrated that protein tissue-enrichment information can explain phenotypes of genetic diseases, which cannot be obtained by transcript information alone. Overall, our results demonstrate how understanding protein levels can provide insights into regulation, secretome, metabolism, and human diseases.
journal_name
Celljournal_title
Cellauthors
Jiang L,Wang M,Lin S,Jian R,Li X,Chan J,Dong G,Fang H,Robinson AE,GTEx Consortium.,Snyder MPdoi
10.1016/j.cell.2020.08.036subject
Has Abstractpub_date
2020-10-01 00:00:00pages
269-283.e19issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(20)31078-3journal_volume
183pub_type
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