Abstract：
:The memory for sensitization of the gill withdrawal reflex in Aplysia is reflected in facilitation of the monosynaptic connection between the sensory and motor neurons of the reflex. The switch from short- to long-term facilitation requires activation of CREB1, derepression of ApCREB2, and induction of ApC/EBP. In search for genes that act downstream from CREB1, we have identified a transcription activator, ApAF, which is stimulated by protein kinase A and can dimerize with both ApC/EBP and ApCREB2. ApAF is necessary for long-term facilitation induced by five pulses of serotonin, by activation of CREB1, or by derepression of ApCREB2. Overexpression of ApAF enhances the long-term facilitation further. Thus, ApAF is a candidate memory enhancer gene downstream from both CREB1 and ApCREB2.
journal_name
Celljournal_title
Cellauthors
Bartsch D,Ghirardi M,Casadio A,Giustetto M,Karl KA,Zhu H,Kandel ERdoi
10.1016/s0092-8674(00)00163-xsubject
Has Abstractpub_date
2000-11-10 00:00:00pages
595-608issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(00)00163-Xjournal_volume
103pub_type
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