Calorie restriction--the SIR2 connection.

abstract：:Cell-penetrating peptides (CPPs) are short protein segments that can transport cargos into cells. Although CPPs are widely studied as potential drug delivery tools, their role in normal cell physiology is poorly understood. Early during infection, the L2 capsid protein of human papillomaviruses binds retromer, a cytop...

journal_title：Cell

authors： Zhang P,Monteiro da Silva G,Deatherage C,Burd C,DiMaio D

更新日期：2018-09-06 00:00:00

abstract：:Spinocerebellar ataxia type 1 (SCA1) is one of nine inherited, typically adult onset, polyglutamine neurodegenerative diseases. To examine whether development impacts SCA1, we used a conditional transgenic mouse model of SCA1 to delay the postnatal expression of mutant ATXN1 until after completion of cerebellar develo...

journal_title：Cell

authors： Serra HG,Duvick L,Zu T,Carlson K,Stevens S,Jorgensen N,Lysholm A,Burright E,Zoghbi HY,Clark HB,Andresen JM,Orr HT

更新日期：2006-11-17 00:00:00

abstract：:Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ...

journal_title：Cell

authors： Aguilar OA,Berry R,Rahim MMA,Reichel JJ,Popović B,Tanaka M,Fu Z,Balaji GR,Lau TNH,Tu MM,Kirkham CL,Mahmoud AB,Mesci A,Krmpotić A,Allan DSJ,Makrigiannis AP,Jonjić S,Rossjohn J,Carlyle JR

更新日期：2017-03-23 00:00:00

abstract：:Here, we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long noncoding RNAs "talk" to each other using microRNA response elements (MREs) as letters of a new language. We propose that this "competing endogenous RNA" (ceRNA) activity forms a large-scale regulatory network across the...

journal_title：Cell

authors： Salmena L,Poliseno L,Tay Y,Kats L,Pandolfi PP

更新日期：2011-08-05 00:00:00

abstract：:Chronic viral infections represent a major burden to human health, and modulation of the immune system is emerging as a novel approach to fighting such infections. Pellegrini et al. (2011) demonstrate that treatment with the cytokine IL-7 may reinvigorate the immune response to persistent infection by targeting immuno...

journal_title：Cell

authors： Parish IA,Kaech SM

更新日期：2011-02-18 00:00:00

abstract：:Interactions between similar but not identical (homeologous) DNA sequences play an important biological role in the evolution of genes and genomes. To gain insight into the underlying molecular mechanism(s) of genetic recombination, we have studied inter- and intramolecular homeologous recombination in S. cerevisiae d...

journal_title：Cell

authors： Mézard C,Pompon D,Nicolas A

更新日期：1992-08-21 00:00:00

abstract：:Yeast heat shock protein 104 (Hsp104), the only known eukaryotic disaggregase, remodels both disordered protein aggregates and cross-β sheet amyloids. To handle this diverse clientele, DeSantis et al. report that Hsp104 hexamers use distinct mechanisms-individual subunits are able to dissolve disordered aggregates, bu...

journal_title：Cell

authors： Murray AN,Kelly JW

更新日期：2012-11-09 00:00:00

abstract：:Insertion/deletion (IDL) mismatches in DNA are lesions consisting of extra bases on one strand. Here, the binding of p53 and its 14 kDa C-terminal domain to DNAs containing one or three 3-cytosine IDL mismatches was examined. Electron microscopy showed that both p53 forms bound predominantly as tetramers at the lesion...

journal_title：Cell

authors： Lee S,Elenbaas B,Levine A,Griffith J

更新日期：1995-06-30 00:00:00

abstract：:In this issue of Cell, Shin et al. report the first live-cell imaging of a fusion pore. Directly visualized pores in neuroendocrine cells can be much larger than expected yet not require vesicular full-collapse. These fusion-fission pores have diverse fates arising from opposing dynamin-driven pore constriction and F-...

journal_title：Cell

authors： Eyring KW,Tsien RW

更新日期：2018-05-03 00:00:00

abstract：:GroEL and GroES form a chaperonin nano-cage for proteins up to approximately 60 kDa to fold in isolation. Here we explored the structural features of the chaperonin cage critical for rapid folding of encapsulated substrates. Modulating the volume of the GroEL central cavity affected folding speed in accordance with co...

journal_title：Cell

authors： Tang YC,Chang HC,Roeben A,Wischnewski D,Wischnewski N,Kerner MJ,Hartl FU,Hayer-Hartl M

更新日期：2006-06-02 00:00:00

abstract：:In RNA-mediated interference (RNAi), double-stranded RNAs (dsRNAs) target complementary mRNAs for degradation. New work demonstrates that essential chromosomal functions are mediated through RNAi protein components and short RNAs, which alter chromosome function at specific DNA loci via histone modification. ...

journal_title：Cell

authors： Dernburg AF,Karpen GH

更新日期：2002-10-18 00:00:00

abstract：:Telomerase is the ribonucleoprotein enzyme that replenishes telomeric DNA and maintains genome integrity. Minimally, telomerase activity requires a templating RNA and a catalytic protein. Additional proteins are required for activity on telomeres in vivo. Here, we report that the Pop1, Pop6, and Pop7 proteins, known c...

journal_title：Cell

authors： Lemieux B,Laterreur N,Perederina A,Noël JF,Dubois ML,Krasilnikov AS,Wellinger RJ

更新日期：2016-05-19 00:00:00

abstract：:Cell surface growth factor receptors couple environmental cues to the regulation of cytoplasmic homeostatic processes, including autophagy, and aberrant activation of such receptors is a common feature of human malignancies. Here, we defined the molecular basis by which the epidermal growth factor receptor (EGFR) tyro...

journal_title：Cell

authors： Wei Y,Zou Z,Becker N,Anderson M,Sumpter R,Xiao G,Kinch L,Koduru P,Christudass CS,Veltri RW,Grishin NV,Peyton M,Minna J,Bhagat G,Levine B

更新日期：2013-09-12 00:00:00

abstract：:To investigate the function of SWI/SNF in site-specific chromatin remodeling at promoters, we have used a purified system to analyze its distribution, function, and retention following recruitment by a sequence-specific transcription activator. Activator recruitment of SWI/SNF bound the complex to promoter proximal nu...

journal_title：Cell

authors： Hassan AH,Neely KE,Workman JL

更新日期：2001-03-23 00:00:00

abstract：:TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We show ...

journal_title：Cell

authors： Demetriades C,Doumpas N,Teleman AA

更新日期：2014-02-13 00:00:00

abstract：:During development, the precise relationships between transcription and chromatin modifications often remain unclear. We use the X chromosome inactivation (XCI) paradigm to explore the implication of chromatin changes in gene silencing. Using female mouse embryonic stem cells, we initiate XCI by inducing Xist and then...

journal_title：Cell

authors： Żylicz JJ,Bousard A,Žumer K,Dossin F,Mohammad E,da Rocha ST,Schwalb B,Syx L,Dingli F,Loew D,Cramer P,Heard E

更新日期：2019-01-10 00:00:00

abstract：:ATP-dependent proteases are vital to maintain cellular protein homeostasis. Here, we study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E. coli to understand how these machines couple ATP hydrolysis to mechanical protein unfolding. Single-molecule analyses reveal that pho...

journal_title：Cell

authors： Sen M,Maillard RA,Nyquist K,Rodriguez-Aliaga P,Pressé S,Martin A,Bustamante C

更新日期：2013-10-24 00:00:00

abstract：:Mice deficient for interleukin-2 develop normally during the first 3-4 weeks of age. However, later on they become severely compromised, and about 50% of the animals die between 4 and 9 weeks after birth. Of the remaining mice, 100% develop an inflammatory bowel disease with striking clinical and histological similari...

journal_title：Cell

authors： Sadlack B,Merz H,Schorle H,Schimpl A,Feller AC,Horak I

更新日期：1993-10-22 00:00:00

abstract：:The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1. Homozygous mutants die at embryonic day 16.5. Their phenotype includes severe craniofac...

journal_title：Cell

authors： Cecconi F,Alvarez-Bolado G,Meyer BI,Roth KA,Gruss P

更新日期：1998-09-18 00:00:00

abstract：:p25rum1 from the fission yeast S. pombe is shown to act as a specific in vitro inhibitor of the p34cdc2/p56cdc13 mitotic kinase. It is also shown that early G1 cells contain p25rum1, which associates with and inhibits the mitotic kinase, and maintains p56cdc13 mitotic B cyclin at a low level, ensuring that these cells...

journal_title：Cell

authors： Correa-Bordes J,Nurse P

更新日期：1995-12-15 00:00:00

abstract：:Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured either in the absence of DHT or presence of pharmacological concentrations of...

journal_title：Cell

authors： Mak TW,Rutledge G,Sutherland DJ

更新日期：1976-02-01 00:00:00

abstract：:Protein aggregation is linked with neurodegeneration and numerous other diseases by mechanisms that are not well understood. Here, we have analyzed the gain-of-function toxicity of artificial β sheet proteins that were designed to form amyloid-like fibrils. Using quantitative proteomics, we found that the toxicity of ...

journal_title：Cell

authors： Olzscha H,Schermann SM,Woerner AC,Pinkert S,Hecht MH,Tartaglia GG,Vendruscolo M,Hayer-Hartl M,Hartl FU,Vabulas RM

更新日期：2011-01-07 00:00:00

abstract：:A large (approximately 200 kd) subunit of cellular RNA polymerase II (Pol II) and a virus-encoded subunit of rabbit poxvirus (RPV) RNA polymerase (137 kd) react with common monoclonal antibodies. Hybridization studies with viral and cellular DNA clones confirm that the viral and cellular proteins are related. Followin...

journal_title：Cell

authors： Morrison DK,Moyer RW

更新日期：1986-02-28 00:00:00

abstract：:Recent studies have revealed that multiple intracellular signaling proteins may assemble into structured, yet sometimes infinite, higher-order signaling machines for transmission of receptor activation information to cellular responses. These studies advance our understanding of cell signaling and implicate new molecu...

journal_title：Cell

authors： Wu H

更新日期：2013-04-11 00:00:00

abstract：:The full-length cDNA for a transcriptional activator, DBP, that binds to the D site of the albumin promoter has been cloned. DBP belongs to a family of related transcription factors including Fos, Jun, CREB, and C/EBP, which share a conserved basic domain. However, unlike most other members of this family, DBP does no...

journal_title：Cell

authors： Mueller CR,Maire P,Schibler U

更新日期：1990-04-20 00:00:00

abstract：:Ischemia-associated oxidative damage leading to necrosis is a major cause of catastrophic tissue loss, and elucidating its signaling mechanism is therefore of paramount importance. p53 is a central stress sensor responding to multiple insults, including oxidative stress to orchestrate apoptotic and autophagic cell dea...

journal_title：Cell

authors： Vaseva AV,Marchenko ND,Ji K,Tsirka SE,Holzmann S,Moll UM

更新日期：2012-06-22 00:00:00

abstract：:Gene silencing is instrumental to interrogate gene function and holds promise for therapeutic applications. Here, we repurpose the endogenous retroviruses' silencing machinery of embryonic stem cells to stably silence three highly expressed genes in somatic cells by epigenetics. This was achieved by transiently expres...

journal_title：Cell

authors： Amabile A,Migliara A,Capasso P,Biffi M,Cittaro D,Naldini L,Lombardo A

更新日期：2016-09-22 00:00:00

abstract：:We mutated, by gene targeting, the endogenous hypoxanthine phosphoribosyl transferase (HPRT) gene in mouse embryo-derived stem (ES) cells. A specialized construct of the neomycin resistance (neor) gene was introduced into an exon of a cloned fragment of the Hprt gene and used to transfect ES cells. Among the G418r col...

journal_title：Cell

authors： Thomas KR,Capecchi MR

更新日期：1987-11-06 00:00:00

abstract：:All recombination models postulate one or more recombination intermediates that are joint molecules containing two homologous parental molecules. A spike of branched DNA molecules not seen in DNA from mitotic cells was found in the two-dimensional gel analysis of meiotic DNA from S. cerevisiae. The mass of molecules i...

journal_title：Cell

authors： Collins I,Newlon CS

更新日期：1994-01-14 00:00:00

abstract：:Alzheimer's disease (AD) is a genetically heterogeneous disorder characterized by early hippocampal atrophy and cerebral amyloid-beta (Abeta) peptide deposition. Using TissueInfo to screen for genes preferentially expressed in the hippocampus and located in AD linkage regions, we identified a gene on 10q24.33 that we ...

journal_title：Cell

authors： Dreses-Werringloer U,Lambert JC,Vingtdeux V,Zhao H,Vais H,Siebert A,Jain A,Koppel J,Rovelet-Lecrux A,Hannequin D,Pasquier F,Galimberti D,Scarpini E,Mann D,Lendon C,Campion D,Amouyel P,Davies P,Foskett JK,Campagne F

更新日期：2008-06-27 00:00:00