Abstract：
:A large (approximately 200 kd) subunit of cellular RNA polymerase II (Pol II) and a virus-encoded subunit of rabbit poxvirus (RPV) RNA polymerase (137 kd) react with common monoclonal antibodies. Hybridization studies with viral and cellular DNA clones confirm that the viral and cellular proteins are related. Following RPV infection, the Pol II subunit is translocated from the nucleus to the cytoplasmic virosomes, then packaged into mature virus, and is found associated with the viral RNA polymerase purified from virions. The results suggest that the cellular Pol II subunit may be directly involved in the transcription of viral genes.
journal_name
Celljournal_title
Cellauthors
Morrison DK,Moyer RWdoi
10.1016/0092-8674(86)90268-0subject
Has Abstractpub_date
1986-02-28 00:00:00pages
587-96issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(86)90268-0journal_volume
44pub_type
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