Abstract：
:The budding yeast, Saccharomyces cerevisiae, has emerged as an archetype of eukaryotic cell biology. Here we show that S. cerevisiae is also a model for the evolution of cooperative behavior by revisiting flocculation, a self-adherence phenotype lacking in most laboratory strains. Expression of the gene FLO1 in the laboratory strain S288C restores flocculation, an altered physiological state, reminiscent of bacterial biofilms. Flocculation protects the FLO1 expressing cells from multiple stresses, including antimicrobials and ethanol. Furthermore, FLO1(+) cells avoid exploitation by nonexpressing flo1 cells by self/non-self recognition: FLO1(+) cells preferentially stick to one another, regardless of genetic relatedness across the rest of the genome. Flocculation, therefore, is driven by one of a few known "green beard genes," which direct cooperation toward other carriers of the same gene. Moreover, FLO1 is highly variable among strains both in expression and in sequence, suggesting that flocculation in S. cerevisiae is a dynamic, rapidly evolving social trait.
journal_name
Celljournal_title
Cellauthors
Smukalla S,Caldara M,Pochet N,Beauvais A,Guadagnini S,Yan C,Vinces MD,Jansen A,Prevost MC,Latgé JP,Fink GR,Foster KR,Verstrepen KJdoi
10.1016/j.cell.2008.09.037subject
Has Abstractpub_date
2008-11-14 00:00:00pages
726-37issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(08)01193-8journal_volume
135pub_type
杂志文章相关文献
CELL文献大全abstract：:Purified budded virions of Autographa californica nuclear polyhedrosis virus (AcNPV) contain abundant amounts of free ubiquitin, which has an altered electrophoretic mobility on SDS gels as compared with standard ubiquitin. Phase extraction of virion proteins with Triton X-114 indicated that the modified form of ubiqu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90413-1
更新日期：1995-01-27 00:00:00
abstract：:Serum response factor (SRF) forms a ternary complex at the c-fos serum response element (SRE) with an accessory factor, Elk-1. We constructed altered-binding specificity derivatives of SRF and Elk-1 that form a ternary complex at a mutated, inactive SRE; like Elk-1, the Elk-1 variant only binds its target as part of a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90238-l
更新日期：1993-04-23 00:00:00
abstract：:The amino acid glutamine has a central role in nitrogen metabolism. Although the molecular mechanisms responsible for its transport across cell membranes remain poorly understood, classical amino acid transport system N appears particularly important. Using intracellular pH measurements, we have now identified an orph...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81674-8
更新日期：1999-12-23 00:00:00
abstract：:Genetic analyses in Drosophila have demonstrated that the multipass membrane protein Smoothened (Smo) is essential for all Hedgehog signaling. We show that Smo acts epistatic to Ptc1 to mediate Shh and Ihh signaling in the early mouse embryo. Smo and Shh/Ihh compound mutants have identical phenotypes: embryos fail to ...
journal_title：Cell
pub_type： 杂志文章
doi：
更新日期：2001-06-15 00:00:00
abstract：:In Drosophila melanogaster males, the sex chromosomes pair during meiosis in the centric X heterochromatin and at the base of the short arm of the Y (YS), in the vicinity of the nucleolus organizers. X chromosomes deficient for the pairing region segregate randomly from the Y. In this report we show that a single ribo...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(90)90215-z
更新日期：1990-04-06 00:00:00
abstract：:During asymmetric cell divisions, mitotic spindles align along the axis of polarization. In invertebrates, spindle positioning requires Pins or related proteins and a G protein alpha subunit. A mammalian Pins, called LGN, binds Galphai and also interacts through an N-terminal domain with the microtubule binding protei...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.10.028
更新日期：2004-11-12 00:00:00
abstract：:Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. PAR1 is proposed to be involved in the invasive and metastatic processes of various cancers. However, the protease responsible for activating the proinvasive...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.12.018
更新日期：2005-02-11 00:00:00
abstract：:Autosomal-dominant dyskeratosis congenita is associated with heterozygous mutations in telomerase. To examine the dosage effect of telomerase, we generated a line of mTR+/- mice on the CAST/EiJ background, which has short telomeres. Interbreeding of heterozygotes resulted in progressive telomere shortening, indicating...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.11.020
更新日期：2005-12-16 00:00:00
abstract：:The majority of the mRNA molecules in HeLa cells contain 1-2 residue(s) of m6Ap and one blocked, methylated 5' terminal "cap" structure. The hnRNA, which is longer than mRNA, contains both m6Ap and caps but 4-6 times as many m6Ap residues per chain. In addition, nuclear molecules contain T2 RNA ase-resistant, methyl-l...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90022-2
更新日期：1976-02-01 00:00:00
abstract：:Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomen...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2019.01.043
更新日期：2019-02-21 00:00:00
abstract：:ATP-dependent proteases are vital to maintain cellular protein homeostasis. Here, we study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E. coli to understand how these machines couple ATP hydrolysis to mechanical protein unfolding. Single-molecule analyses reveal that pho...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.09.022
更新日期：2013-10-24 00:00:00
abstract：:p53 is a key tumor suppressor protein that has numerous functions. Its primary mode of action has generally been ascribed to the induction of cell-cycle arrest, apoptosis, or senescence upon stress. Li et al. challenge this dogma with evidence that all three of these programs are dispensable for p53's tumor suppressiv...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.05.024
更新日期：2012-06-08 00:00:00
abstract：:We have devised a genetic strategy to isolate the target of acidic activation domains of transcriptional activators based on toxicity in yeast cells of the chimeric activator, GAL4-VP16. Toxicity required the integrity of both the VP16 acidic activation domain and the GAL4 DNA-binding domain, suggesting that inhibitio...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90100-q
更新日期：1992-07-24 00:00:00
abstract：:Coronavirus disease 2019 (COVID-19) is a novel respiratory illness caused by SARS-CoV-2. Viral entry is mediated through viral spike protein and host ACE2 enzyme interaction. Most cases are mild; severe disease often involves cytokine storm and organ failure. Therapeutics including antivirals, immunomodulators, and va...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.04.013
更新日期：2020-05-14 00:00:00
abstract：:Due to the rapid emergence of antibiotic-resistant bacteria, there is a growing need to discover new antibiotics. To address this challenge, we trained a deep neural network capable of predicting molecules with antibacterial activity. We performed predictions on multiple chemical libraries and discovered a molecule fr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.01.021
更新日期：2020-02-20 00:00:00
abstract：:A hybrid beta-galactosidase molecule containing a substantial portion of the amino-terminal sequence of the maltose-binding protein is inserted in the cytoplasmic membrane of E. coli; in this location, the protein has very low enzymatic activity. The strain producing it is, therefore, Lac-. Selection for derivatives o...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90184-7
更新日期：1981-09-01 00:00:00
abstract：:A diverse range of ultimate chemical carcinogens inhibited the transfer of methyl groups from S-adenosylmethionine to hemimethylated DNA in a reaction catalyzed by mouse spleen methyltransferase. The formation of alkali-labile sites in DNA lessened its ability to accept methyl groups in vitro, but the methylation reac...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90514-7
更新日期：1983-01-01 00:00:00
abstract：:We investigated soybean lectin gene structure and expression in a genetic line that accumulates normal levels of seed lectin (Le+ line) and in a mutant line that produces no detectable seed lectin (Le- line). We found that the nuclear and cytoplasmic lectin RNA levels in Le- embryos are approximately 0.01% of those in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90428-2
更新日期：1983-06-01 00:00:00
abstract：:In this issue of Cell, Uderhardt et al. employed intravital two-photon microscopy to examine tissue-resident macrophage responses to sterile cellular injuries of variable size. They observed that while multi-cell "macrolesions" are characteristically pro-inflammatory, resident macrophages can "cloak" single-cell micro...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2019.03.042
更新日期：2019-04-18 00:00:00
abstract：:The replication initiator protein of the plasmid R6K binds to seven contiguous 22 bp direct repeats that form an indispensable part of the three replication origins alpha, beta, and gamma. Binding of the initiator to the direct repeats induced a marked bending of the region of gamma replication origin. Binding of the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90023-6
更新日期：1985-11-01 00:00:00
abstract：:We are studying mice that carry a targeted disruption of the gene encoding insulin-like growth factor II (IGF-II). Transmission of this mutation through the male germline results in heterozygous progeny that are growth deficient. In contrast, when the disrupted gene is transmitted maternally, the heterozygous offsprin...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90513-x
更新日期：1991-02-22 00:00:00
abstract：:Uracil-DNA glycosylase inhibitor (Ugi) is a B. subtilis bacteriophage protein that protects the uracil-containing phage DNA by irreversibly inhibiting the key DNA repair enzyme uracil-DNA glycosylase (UDG). The 1.9 A crystal structure of Ugi complexed to human UDG reveals that the Ugi structure, consisting of a twiste...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90467-0
更新日期：1995-09-08 00:00:00
abstract：:When transcription regulatory networks are compared among distantly related eukaryotes, a number of striking similarities are observed: a larger-than-expected number of genes, extensive overlapping connections, and an apparently high degree of functional redundancy. It is often assumed that the complexity of these net...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2015.04.014
更新日期：2015-05-07 00:00:00
abstract：:The Mre11/Rad50 complex has been implicated in the early steps of DNA double-strand break (DSB) repair through homologous recombination in several organisms. However, the enzymatic properties of this complex are incompatible with the generation of 3' single-stranded DNA for recombinase loading and strand exchange. In ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.09.054
更新日期：2008-10-17 00:00:00
abstract：:A key aspect of genomic medicine is to make individualized clinical decisions from personal genomes. We developed a machine-learning framework to integrate personal genomes and electronic health record (EHR) data and used this framework to study abdominal aortic aneurysm (AAA), a prevalent irreversible cardiovascular ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.07.021
更新日期：2018-09-06 00:00:00
abstract：:Members of the myocyte enhancer factor-2 (MEF2) family of MADS domain transcription factors cannot induce myogenesis in transfected fibroblasts, but when coexpressed with the myogenic basic-helix-loop-helix (bHLH) proteins MyoD or myogenin they dramatically increase the extent of myogenic conversion above that seen wi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90139-6
更新日期：1995-12-29 00:00:00
abstract：:The c-Abl tyrosine kinase is inhibited by mechanisms that are poorly understood. Disruption of these mechanisms in the Bcr-Abl oncoprotein leads to several forms of human leukemia. We found that like Src kinases, c-Abl 1b is activated by phosphotyrosine ligands. Ligand-activated c-Abl is particularly sensitive to the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(03)00191-0
更新日期：2003-03-21 00:00:00
abstract：:Type 2 diabetes (T2D) is a worldwide epidemic with a medical need for additional targeted therapies. Suppression of hepatic glucose production (HGP) effectively ameliorates diabetes and can be exploited for its treatment. We hypothesized that targeting PGC-1α acetylation in the liver, a chemical modification known to ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.03.001
更新日期：2017-03-23 00:00:00
abstract：:Nerve regeneration and developmental outgrowth of axons are both correlated with increased synthesis of an axonal membrane protein designated GAP-43. Phosphorylation of an apparently identical protein, present at lower abundance in adult brains, has been correlated with long-term potentiation, a form of synaptic plast...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90616-7
更新日期：1987-06-19 00:00:00
abstract：:A gel electrophoresis DNA binding assay has been used to identify proteins in HeLa cell extracts that specifically bind to the major late promoter of adenovirus. A major late promoter transcription factor MLTF has been detected as a discrete protein-DNA complex. MLTF binds specifically and with high affinity to sequen...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90174-6
更新日期：1985-12-01 00:00:00
