Abstract：
:Complex multicellular organisms, such as mammals, express two complete sets of chromosomes per nucleus, combining the genetic material of both parents. However, epigenetic studies have demonstrated violations to this rule that are necessary for mammalian physiology; the most notable parental allele expression phenomenon is genomic imprinting. With the identification of endogenous imprinted genes, genomic imprinting became well-established as an epigenetic mechanism in which the expression pattern of a parental allele influences phenotypic expression. The expanding study of genomic imprinting is revealing a significant impact on brain functions and associated diseases. Here, we review key milestones in the field of imprinting and discuss mechanisms and systems in which imprinted genes exert a significant role.
journal_name
Celljournal_title
Cellauthors
Tucci V,Isles AR,Kelsey G,Ferguson-Smith AC,Erice Imprinting Group.doi
10.1016/j.cell.2019.01.043subject
Has Abstractpub_date
2019-02-21 00:00:00pages
952-965issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(19)30106-0journal_volume
176pub_type
杂志文章,评审相关文献
CELL文献大全abstract：:Release of CHO-K1 cells from plateau or stationary phase and reentry into the cell cycle is specifically and reversibly blocked at two distinct sites by the anticalmodulin drug W13. The first block occurs early during release while the cells are still at G0/G1, whereas the second occurs later in reentry during early S...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90075-8
更新日期：1984-01-01 00:00:00
abstract：:The association of histone modification changes with autism spectrum disorder (ASD) has not been systematically examined. We conducted a histone acetylome-wide association study (HAWAS) by performing H3K27ac chromatin immunoprecipitation sequencing (ChIP-seq) on 257 postmortem samples from ASD and matched control brai...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.10.031
更新日期：2016-11-17 00:00:00
abstract：:We studied the chromatin structure and methylation of ribosomal RNA genes (rDNA) in hybrids between Xenopus laevis and Xenopus borealis. S1-nuclease protection experiments showed that 97%-98% of the rRNA precursor in hybrid tadpoles was of the X. laevis type. Preferential expression of the laevis rDNA was correlated w...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90105-2
更新日期：1982-05-01 00:00:00
abstract：:X-ray studies have established that the structure of a right-handed, Watson-Crick double helix can change from place to place along its length as a function of base sequence. The base pairs transmit deformations out to the phosphate backbone, where they can then be recognized by proteins and other DNA-binding reagents...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(84)90379-9
更新日期：1984-06-01 00:00:00
abstract：:Fos protein can trans-activate AP-1-dependent gene expression and trans-repress the c-fos promoter. Although we find that trans-repression is enhanced by coexpression of c-Jun, it does not require any of the AP-1 or ATF sites in the mouse c-fos promoter. A major target for repression is the serum response element (SRE...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90756-3
更新日期：1989-12-22 00:00:00
abstract：:The 5' terminal structure of the mRNA synthesized in vitro by the virion-associated RNA polymerase of vesicular stomatitis virus in the presence of S-adenosyl-L-methione consists of 7-methyl guanosine linked to 2'-O-methyl adenosine through a 5'-5' pyrophosphate bond as m7G(5')ppp(5')A-m-p ... The alpha and beta phosp...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(75)90091-4
更新日期：1975-05-01 00:00:00
abstract：:Hunger and thirst have distinct goals but control similar ingestive behaviors, and little is known about neural processes that are shared between these behavioral states. We identify glutamatergic neurons in the peri-locus coeruleus (periLCVGLUT2 neurons) as a polysynaptic convergence node from separate energy-sensiti...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.07.031
更新日期：2020-09-17 00:00:00
abstract：:Forms of RNA polymerase I prepared from growing or encysted Acanthamoeba are equal in the ability to transcribe poly(dl:dC). Polymerase from cysts, whose rRNA genes are transcriptionally inactive, is unable to utilize the rDNA promoter in vitro, whereas the transcription initiation factor from cysts is fully able to b...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90601-x
更新日期：1986-11-07 00:00:00
abstract：:Dysfunction and loss of insulin-producing pancreatic beta cells represent hallmarks of diabetes mellitus. Here, we show that mice lacking the mitogen-activated protein kinase (MAPK) p38delta display improved glucose tolerance due to enhanced insulin secretion from pancreatic beta cells. Deletion of p38delta results in...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.11.018
更新日期：2009-01-23 00:00:00
abstract：:Organ cultures of liver from untreated male Xenopus respond to 17 beta-estradiol in the culture medium by synthesizing and secreting the yolk protein precursor vitellogenin. Vitellogenin synthesis, as a primary response, is first detectable on the fourth day of culture, and comprises up to 12% of the protein synthesiz...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90263-4
更新日期：1976-01-01 00:00:00
abstract：:Although a great deal is known biochemically about peroxiredoxins (Prxs), little is known about their real physiological function. We show here that two cytosolic yeast Prxs, cPrxI and II, which display diversity in structure and apparent molecular weights (MW), can act alternatively as peroxidases and molecular chape...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2004.05.002
更新日期：2004-05-28 00:00:00
abstract：:A glycoprotein of molecular weight 130,000 (gP130) has been precipitated from the cytoplasm of GR-strain mouse mammary tumor (GR-MMT) cells by a rabbit antiserum (anti-MMTV) to GR-strain mouse mammary tumor virus (GR-MMTV). This protein was not precipitated by antisera specific for detergent-disrupted C3H-strain MMTV ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(80)90447-x
更新日期：1980-10-01 00:00:00
abstract：:The HIV-1 Tat protein is a potent trans-activator essential for virus replication. We reported previously that HIV-1 Tat peptides containing residues 37-48 (mainly region II), a possible activating region, and residues 49-57 (region III), a nuclear targeting and putative nucleic acid binding region, possess minimal bu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90417-0
更新日期：1989-07-14 00:00:00
abstract：:Different hematopoietic cells produce minute amounts of beta-related interferon (IFN) following induction of differentiation by chemical or natural inducers. The endogenous IFN binds to type I cell surface receptors and modulates gene expression in the producer cells. We show that self-induction of two members of the ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(86)90857-3
更新日期：1986-07-04 00:00:00
abstract：:Chemotherapy results in a frequent yet poorly understood syndrome of long-term neurological deficits. Neural precursor cell dysfunction and white matter dysfunction are thought to contribute to this debilitating syndrome. Here, we demonstrate persistent depletion of oligodendrocyte lineage cells in humans who received...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.10.049
更新日期：2019-01-10 00:00:00
abstract：:An examination of Abelson murine leukemia virus (A-MuL V)-hematopoietic cell interaction in cultures of fetal tissues reveals that A-MuLV can stimulate the formation of two different types of colonies. One type of colony is white and composed of A-MuLV-transformed lymphoid cells that can develop into established cell ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90035-0
更新日期：1981-10-01 00:00:00
abstract：:In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting a...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2005.01.006
更新日期：2005-01-28 00:00:00
abstract：:The role of S. cerevisiae YDJ1 protein (YDJ1p) in polypeptide translocation across membranes has been examined. A conditional ydj1 mutant strain (ydj1-151TS) is defective for import of several polypeptides into mitochondria and alpha factor into the endoplasmic reticulum at 37 degrees C. These defects are suppressed b...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(05)80063-7
更新日期：1992-12-24 00:00:00
abstract：:Brown and beige adipocytes are specialized cells that express uncoupling protein 1 (UCP1) and dissipate chemical energy as heat. These cells likely possess alternative UCP1-independent thermogenic mechanisms. Here, we identify a secreted enzyme, peptidase M20 domain containing 1 (PM20D1), that is enriched in UCP1(+) v...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.05.071
更新日期：2016-07-14 00:00:00
abstract：:RGS proteins are GTPase activators for heterotrimeric G proteins. We report here the 2.8 A resolution crystal structure of the RGS protein RGS4 complexed with G(i alpha1)-Mg2+-GDP-AlF4 . Only the core domain of RGS4 is visible in the crystal. The core domain binds to the three switch regions of G(i alpha1), but does n...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80204-4
更新日期：1997-04-18 00:00:00
abstract：:During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2005.10.015
更新日期：2005-11-04 00:00:00
abstract：:Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90479-4
更新日期：1995-09-08 00:00:00
abstract：:We have isolated a dominant mutation in a gene called Son of sevenless (Sos) that is an allele-specific suppressor of the sevenless phenotype. This suppressor function is autonomously required in R7 and is sensitive to the dosage of the Sos and bride of sevenless genes. Loss-of-function alleles of Sos are recessive le...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90207-f
更新日期：1991-01-11 00:00:00
abstract：:Small nucleolar RNAs represent an abundant, evolutionarily ancient group of noncoding RNAs which possess impressively diverse functions ranging from 2'-O-methylation and pseudouridylation of various classes of RNAs, through nucleolytic processing of rRNAs to the synthesis of telomeric DNA. ...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/s0092-8674(02)00718-3
更新日期：2002-04-19 00:00:00
abstract：:The nucleotide sequences of the 3' termini of the DNA from four autonomous rodent parvoviruses have been determined. The terminus of each genome exists as a Y-shaped hairpin structure involving 115 or 116 nucleotides. The sequence of this region of DNA is highly conserved and shows no evidence of internal sequence het...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(79)90276-9
更新日期：1979-07-01 00:00:00
abstract：:The yeast [PSI+] factor is inherited by a prion mechanism involving self-propagating Sup35p aggregates. We find that Sup35p prion function is conserved among distantly related yeasts. As with mammalian prions, a species barrier inhibits prion induction between Sup35p from different yeast species. This barrier is faith...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81565-2
更新日期：2000-01-21 00:00:00
abstract：:In eukaryotic cells, organelles and the cytoskeleton undergo highly dynamic yet organized interactions capable of orchestrating complex cellular functions. Visualizing these interactions requires noninvasive, long-duration imaging of the intracellular environment at high spatiotemporal resolution and low background. T...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.09.057
更新日期：2018-11-15 00:00:00
abstract：:I have identified an activity in crude HeLa cell extracts that satisfies the requirements for a human telomere terminal transferase or telomerase. It catalyzes the addition of a 6 nucleotide repeating pattern to oligonucleotide primers containing human or nonhuman telomeric repeat sequences. Direct sequence analyses o...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90035-4
更新日期：1989-11-03 00:00:00
abstract：:Hedgehog (Hh) proteins play diverse organizing roles in development by regulating gene expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Hh target genes. A repressor form of Ci arises in the absence of Hh signaling by proteolytic cleavage of intact...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80592-9
更新日期：1999-03-19 00:00:00
abstract：:Five single base pair mutations that increase expression of the tnpA (transposase) gene of the Tn3 transposon approximately 30-fold, but which still allow the gene to be regulated, have been isolated by using a generally applicable procedure that involves distally linked lac gene fusions. The mutations, which are all ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(82)90352-x
更新日期：1982-02-01 00:00:00
