Abstract:
:We are studying mice that carry a targeted disruption of the gene encoding insulin-like growth factor II (IGF-II). Transmission of this mutation through the male germline results in heterozygous progeny that are growth deficient. In contrast, when the disrupted gene is transmitted maternally, the heterozygous offspring are phenotypically normal. Therefore, the difference in growth phenotypes depends on the type of gamete contributing the mutated allele. Homozygous mutants are indistinguishable in appearance from growth-deficient heterozygous siblings. Nuclease protection and in situ hybridization analyses of the transcripts from the wild-type and mutated alleles indicate that only the paternal allele is expressed in embryos, while the maternal allele is silent. An exception is the choroid plexus and leptomeninges, where both alleles are transcriptionally active. These results demonstrate that IGF-II is indispensable for normal embryonic growth and that the IGF-II gene is subject to tissue-specific parental imprinting.
journal_name
Celljournal_title
Cellauthors
DeChiara TM,Robertson EJ,Efstratiadis Adoi
10.1016/0092-8674(91)90513-xsubject
Has Abstractpub_date
1991-02-22 00:00:00pages
849-59issue
4eissn
0092-8674issn
1097-4172pii
0092-8674(91)90513-Xjournal_volume
64pub_type
杂志文章相关文献
CELL文献大全abstract::The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF com...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(01)00446-9
更新日期:2001-08-10 00:00:00
abstract::In the nucleus of eukaryotic cells, RNA decay in the 3'-5' direction is carried out by a complex of exonucleases called the exosome. Surprisingly, the purified exosome shows only weak activity in vitro. Two papers in this issue of Cell, by LaCava et al. (2005) and Wyers et al. (2005), and a third report by Vanacova et...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2005.05.018
更新日期:2005-06-03 00:00:00
abstract::To defend cells against viruses, the MAVS (mitochondrial antiviral signaling) adaptor protein initiates an antiviral signaling cascade from mitochondrial membranes. In this issue, Dixit et al. (2010) show that MAVS also localizes to the membranes of peroxisomes, where it rapidly induces expression of a subset of antiv...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2010.04.043
更新日期:2010-05-14 00:00:00
abstract::A model of hematopoietic development wherein multipotentiality is conserved until segregation of myeloid and lymphoid potential has recently been challenged, proposing that megakaryocyte/erythrocyte (MegE) potential is lost in Flk2/Flt3-expressing early progenitors. Here, we used sensitive in vivo approaches to quanti...
journal_title:Cell
pub_type: 信件
doi:10.1016/j.cell.2006.06.037
更新日期:2006-07-28 00:00:00
abstract::On each side of the midline of the Drosophila CNS, axons are organized into a series of parallel pathways. Here we show that the midline repellent Slit, previously identified as a short-range signal that regulates midline crossing, also functions at long range to pattern these longitudinal pathways. In this long-range...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)00207-5
更新日期:2000-12-22 00:00:00
abstract::Certain mutant alleles at the low density lipoprotein (LDL) receptor locus produce receptors that bind LDL normally, but fail to cluster in coated pits and therefore cannot transport LDL into cells. We prepared genomic DNA libraries from cells of two individuals with this phenotype (internalization-defective familial ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(85)80054-4
更新日期:1985-07-01 00:00:00
abstract::Organ cultures of liver from untreated male Xenopus respond to 17 beta-estradiol in the culture medium by synthesizing and secreting the yolk protein precursor vitellogenin. Vitellogenin synthesis, as a primary response, is first detectable on the fourth day of culture, and comprises up to 12% of the protein synthesiz...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(76)90263-4
更新日期:1976-01-01 00:00:00
abstract::The biguanide drug metformin is widely prescribed to treat type 2 diabetes and metabolic syndrome, but its mode of action remains uncertain. Metformin also increases lifespan in Caenorhabditis elegans cocultured with Escherichia coli. This bacterium exerts complex nutritional and pathogenic effects on its nematode pre...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.02.035
更新日期:2013-03-28 00:00:00
abstract::Activation of Agouti-related peptide (AgRP) neurons potently promotes feeding, and chronically altering their activity also affects peripheral glucose homeostasis. We demonstrate that acute activation of AgRP neurons causes insulin resistance through impairment of insulin-stimulated glucose uptake into brown adipose t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.02.044
更新日期:2016-03-24 00:00:00
abstract::The complement system serves an important role in clearance of pathogens, immune complexes, and apoptotic cells present in the circulation. Complement fragments deposited on the particle surface serve as targets for complement receptors present on phagocytic cells. Although Kupffer cells, the liver resident macrophage...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2005.12.039
更新日期:2006-03-10 00:00:00
abstract::Nuclear hormone receptors comprise a superfamily of ligand-modulated transcription factors that mediate the transcriptional activities of steroids, retinoids, and thyroid hormones. A growing number of related proteins have been identified that possess the structural features of hormone receptors, but that lack known l...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90530-8
更新日期:1995-06-02 00:00:00
abstract::We describe automated technologies to probe the structure of neural tissue at nanometer resolution and use them to generate a saturated reconstruction of a sub-volume of mouse neocortex in which all cellular objects (axons, dendrites, and glia) and many sub-cellular components (synapses, synaptic vesicles, spines, spi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.06.054
更新日期:2015-07-30 00:00:00
abstract::In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2020.06.040
更新日期:2020-08-20 00:00:00
abstract::Many neural progenitors, including Drosophila mushroom body (MB) and projection neuron (PN) neuroblasts, sequentially give rise to different subtypes of neurons throughout development. We identified a novel BTB-zinc finger protein, named Chinmo (Chronologically inappropriate morphogenesis), that governs neuronal tempo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.08.045
更新日期:2006-10-20 00:00:00
abstract::Neural progenitors generate distinct cell types at different stages, but the mechanisms controlling these temporal transitions are poorly understood. In the Drosophila CNS, a cascade of transcription factors, the "temporal gene cascade," has been identified that acts to alter progenitor competence over time. However, ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.10.032
更新日期:2009-11-25 00:00:00
abstract::The location of cis-acting regulatory sequences within the long terminal repeat (LTR) of the human T cell lymphotropic virus type III (HTLV-III/LAV) was determined. An enhancer element capable of increasing the rate of transcription from a heterologous promoter, irrespective of distance and orientation, is located bet...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(85)80062-3
更新日期:1985-07-01 00:00:00
abstract::Structures of 70 unique G protein-coupled receptors (GPCRs) have been determined, with over 370 structures in total bound to different ligands and the receptors in various conformational states. Structure-based drug design has been applied to an increasing number of GPCR targets over the past decade and now a few of t...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2020.03.003
更新日期:2020-04-02 00:00:00
abstract::Much like the "microbe hypothesis" put forth over 150 years ago, the "prion hypothesis" can be definitely proven only if a prion disease is engendered in a natural host from an infectious prion produced in vitro. In this issue of Cell, come very close to accomplishing this goal by producing a prion disease in a natura...
journal_title:Cell
pub_type: 评论,杂志文章,评审
doi:10.1016/j.cell.2005.04.002
更新日期:2005-04-22 00:00:00
abstract::Wnt signaling plays a critical role in embryonic development, and genetic aberrations in this network have been broadly implicated in colorectal cancer. We find that the Wnt receptor Frizzled2 (Fzd2) and its ligands Wnt5a/b are elevated in metastatic liver, lung, colon, and breast cancer cell lines and in high-grade t...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.10.032
更新日期:2014-11-06 00:00:00
abstract::A mechanistic description of metazoan transcription is essential for understanding the molecular processes that govern cellular decisions. To provide structural insights into the DNA recognition step of transcription initiation, we used single-particle electron microscopy (EM) to visualize human TFIID with promoter DN...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.12.005
更新日期:2013-01-17 00:00:00
abstract::The specificity of target gene activation by steroid receptors is encoded within a small, cysteine-rich domain that is believed to form two zinc-coordinated fingers. Here we show that the ability of glucocorticoid and estrogen receptors to discriminate between their closely related response elements resides in the two...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90050-0
更新日期:1989-06-30 00:00:00
abstract::Spatiotemporal changes in nuclear lamina composition underlie cell-type-specific chromatin organization and cell fate, suggesting that the lamina forms a dynamic framework critical for genome function, cellular identity, and developmental potential. ...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2013.02.052
更新日期:2013-03-14 00:00:00
abstract::During C. elegans embryogenesis an 8-cell stage blastomere, called MS, undergoes a reproducible cleavage pattern, producing pharyngeal cells, body wall muscles, and cell deaths. We show here that maternal-effect mutations in the pie-1 and mex-1 genes cause additional 8-cell stage blastomeres to adopt a fate very simil...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90542-k
更新日期:1992-07-10 00:00:00
abstract::The mitochondrial RNA binding proteins MRP1 and MRP2 form a heteromeric complex that functions in kinetoplastid RNA editing. In this process, MRP1/MRP2 serves as a matchmaker by binding to guide RNAs and facilitating their hybridization with cognate preedited mRNAs. To understand the mechanism by which this complex pe...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.06.047
更新日期:2006-08-25 00:00:00
abstract::Antisense Piwi-interacting RNAs (piRNAs) guide silencing of established transposons during germline development, and sense piRNAs drive ping-pong amplification of the antisense pool, but how the germline responds to genome invasion is not understood. The KoRV-A gammaretrovirus infects the soma and germline and is swee...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.09.002
更新日期:2019-10-17 00:00:00
abstract::Excessive sun tanning can result in addictive behavior. In this issue of Cell, Fell et al. utilize a combination of behavioral pharmacology and transgenic mice to demonstrate that chronic UV light exposure recruits p53 signaling in keratinocytes, subsequently increasing β-endorphin signaling at opioid receptors, and p...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.06.009
更新日期:2014-06-19 00:00:00
abstract::TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2013.12.002
更新日期:2013-12-19 00:00:00
abstract::The central vasculature of plant roots is protected by a hydrophobic ring of endodermal cells that are enclosed by lamellae of suberin. Barberon et al. demonstrate that endodermal suberization plasticity facilitates ion homeostasis, with antithetical regulation of suberin deposition and degradation by the phytohormone...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2016.01.005
更新日期:2016-01-28 00:00:00
abstract::ATRX is an X-linked gene of the SWI/SNF family, mutations in which cause syndromal mental retardation and downregulation of α-globin expression. Here we show that ATRX binds to tandem repeat (TR) sequences in both telomeres and euchromatin. Genes associated with these TRs can be dysregulated when ATRX is mutated, and ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.09.023
更新日期:2010-10-29 00:00:00
abstract::In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC compone...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2008.11.037
更新日期:2009-01-23 00:00:00