Abstract：
:The location of cis-acting regulatory sequences within the long terminal repeat (LTR) of the human T cell lymphotropic virus type III (HTLV-III/LAV) was determined. An enhancer element capable of increasing the rate of transcription from a heterologous promoter, irrespective of distance and orientation, is located between nucleotides -137 and -17 (cap site +1). The promoter sequences present near the TATA box respond to heterologous enhancers. The sequences present between nucleotides -17 and +80 are responsive to HTLV-III-associated trans-acting regulatory factors. Activation of these sequences by the viral regulatory factors requires the presence of a functional enhancer. The enhancer requirement is nonspecific, as the enhancer sequences of RSV, HTLV-I, and SV40 can functionally replace the HTLV-III enhancer. These findings define a new type of regulatory element, provide insight into the mechanisms that regulate HTLV-III gene expression, and may help to explain the effects of this virus on infected cells.
journal_name
Celljournal_title
Cellauthors
Rosen CA,Sodroski JG,Haseltine WAdoi
10.1016/s0092-8674(85)80062-3subject
Has Abstractpub_date
1985-07-01 00:00:00pages
813-23issue
3eissn
0092-8674issn
1097-4172pii
S0092-8674(85)80062-3journal_volume
41pub_type
杂志文章相关文献
CELL文献大全abstract：:The accurate timing and execution of organelle biogenesis is crucial for cell physiology. Centriole biogenesis is regulated by Polo-like kinase 4 (Plk4) and initiates in S-phase when a daughter centriole grows from the side of a pre-existing mother. Here, we show that a Plk4 oscillation at the base of the growing cent...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.05.018
更新日期：2020-06-25 00:00:00
abstract：:Liddle's syndrome is an inherited form of hypertension caused by mutations that truncate the C-terminus of human epithelial Na+ channel (hENaC) subunits. Expression of truncated beta and gamma hENaC subunits increased Na+ current. However, truncation did not alter single-channel conductance or open state probability, ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90212-0
更新日期：1995-12-15 00:00:00
abstract：:Adult neovascularization relies on the recruitment of circulating cells, but their angiogenic roles and recruitment mechanisms are unclear. We show that the endothelial growth factor VEGF is sufficient for organ homing of circulating mononuclear myeloid cells and is required for their perivascular positioning and rete...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.10.036
更新日期：2006-01-13 00:00:00
abstract：:Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the CO...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.03.006
更新日期：2012-03-30 00:00:00
abstract：:Although specific microRNAs (miRNAs) can be upregulated in cancer, global miRNA downregulation is a common trait of human malignancies. The mechanisms of this phenomenon and the advantages it affords remain poorly understood. Here we identify a microRNA family, miR-103/107, that attenuates miRNA biosynthesis by target...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.05.017
更新日期：2010-06-25 00:00:00
abstract：:Circadian rhythms control organismal physiology throughout the day. At the cellular level, clock regulation is established by a self-sustained Bmal1-dependent transcriptional oscillator network. However, it is still unclear how different tissues achieve a synchronized rhythmic physiology. That is, do they respond inde...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2019.05.009
更新日期：2019-05-30 00:00:00
abstract：:Cellular receptors are required for efficient entry of retroviruses into cells. We previously cloned a chicken gene responsible for susceptibility to the retrovirus subgroup A Rous sarcoma virus (RSV(A)). Here we have isolated the quail homolog and generated two alternatively spliced processed genes encoding cellular ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90726-7
更新日期：1993-09-24 00:00:00
abstract：:We show that expression of the iso-1-cytochrome c gene of Saccharomyces cerevisiae, CYC1, is tightly regulated by levels of intracellular heme. Expression is reduced at least 200-fold in cells grown under conditions of heme deficiency. Studies on the regulation of a CYC1-lacZ fused gene and direct determination of mRN...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90309-4
更新日期：1983-04-01 00:00:00
abstract：:Serum response factor (SRF) forms a ternary complex at the c-fos serum response element (SRE) with an accessory factor, Elk-1. We constructed altered-binding specificity derivatives of SRF and Elk-1 that form a ternary complex at a mutated, inactive SRE; like Elk-1, the Elk-1 variant only binds its target as part of a...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90238-l
更新日期：1993-04-23 00:00:00
abstract：:Clarification of the information processing system in bacterial sensing has been obtained by studying mutants that lack the capacity to modify receptors covalently. The remaining part of the system is able to receive signals from the receptor, to respond with partial adaptation, and to exhibit a chemotactic response. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(85)90125-4
更新日期：1985-09-01 00:00:00
abstract：:Human autoantibodies that recognize the spindle poles of mammals, plants, and insects were found to recognize two antigens in yeast. One of these proteins, called SPA1 (for Spindle Pole Antigen), is antigenically related to the spindle poles of a diverse set of organisms. The gene encoding SPA1 was cloned by immunoscr...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(88)90977-4
更新日期：1988-09-09 00:00:00
abstract：:In the mouse, the zona pellucida (ZP) glycoprotein ZP3 both binds intact sperm and induces acrosomal exocytosis. The subsequent signaling pathway(s) is still uncertain, but Gi-like proteins have been implicated. By analogy with other signal transduction mechanisms, we examined anti-phosphotyrosine antibody reactivity ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(89)90049-4
更新日期：1989-06-30 00:00:00
abstract：:Histone methylation regulates chromatin structure and transcription. The recently identified histone demethylase lysine-specific demethylase 1 (LSD1) is chemically restricted to demethylation of only mono- and di- but not trimethylated histone H3 lysine 4 (H3K4me3). We show that the X-linked mental retardation (XLMR) ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.02.017
更新日期：2007-03-23 00:00:00
abstract：:Using cryo-electron microscopy, we have solved the structure of an icosidodecahedral COPII coat involved in cargo export from the endoplasmic reticulum (ER) coassembled from purified cargo adaptor Sec23-24 and Sec13-31 lattice-forming complexes. The coat structure shows a tetrameric assembly of the Sec23-24 adaptor la...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2008.06.024
更新日期：2008-08-08 00:00:00
abstract：:Spinal cord injuries alter motor function by disconnecting neural circuits above and below the lesion, rendering sensory inputs a primary source of direct external drive to neuronal networks caudal to the injury. Here, we studied mice lacking functional muscle spindle feedback to determine the role of this sensory cha...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2014.11.019
更新日期：2014-12-18 00:00:00
abstract：:Although current immune-checkpoint therapy (ICT) mainly targets lymphoid cells, it is associated with a broader remodeling of the tumor micro-environment. Here, using complementary forms of high-dimensional profiling, we define differences across all hematopoietic cells from syngeneic mouse tumors during unrestrained ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.09.030
更新日期：2018-11-01 00:00:00
abstract：:Huntington's disease (HD) is an incurable neuropsychiatric disease associated with CAG repeat expansion within a widely expressed gene that causes selective neuronal death. To understand its normal function, we have created a targeted disruption in exon 5 of Hdh (Hdhex5), the murine homolog of the HD gene. Homozygotes...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90542-1
更新日期：1995-06-02 00:00:00
abstract：:The 2013-2015 West African epidemic of Ebola virus disease (EVD) reminds us of how little is known about biosafety level 4 viruses. Like Ebola virus, Lassa virus (LASV) can cause hemorrhagic fever with high case fatality rates. We generated a genomic catalog of almost 200 LASV sequences from clinical and rodent reserv...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.07.020
更新日期：2015-08-13 00:00:00
abstract：:Viruses are adept at evolving or co-opting genomic elements that allow them to maximize their replication potential in the infected host. This evolutionary plasticity makes viruses an invaluable system to identify new mechanisms used not only by viruses but also by vertebrate cells to modulate gene expression. Here, I...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.01.048
更新日期：2009-02-20 00:00:00
abstract：:Bacteria have evolved many different means of generating movement. In this issue of Cell, Shaevitz et al. (2005) describe the swimming movement of a helical bacterium called Spiroplasma. They discover that Spiroplasma propels itself by generating two temporally distinct kinks that travel the length of the bacterium. T...
journal_title：Cell
pub_type： 评论,杂志文章,评审
doi：10.1016/j.cell.2005.09.003
更新日期：2005-09-23 00:00:00
abstract：:Most human epithelial tumors harbor numerous alterations, making it difficult to predict which genes are required for tumor survival. To systematically identify cancer dependencies, we analyzed 501 genome-scale loss-of-function screens performed in diverse human cancer cell lines. We developed DEMETER, an analytical f...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.06.010
更新日期：2017-07-27 00:00:00
abstract：:The proportion of BFU-E normally engaged in DNA synthesis is low in adult B6 (C57BL/6) mice of genotype Fv2rr (resistant to Friend erythroleukemia virus), as shown by 3H-thymidine or hydroxyurea "cell suicide" experiments in vivo and vitro. When bone marrow cells from these mice were subjected to a single wash in alph...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(81)90306-8
更新日期：1981-10-01 00:00:00
abstract：:torso encodes a receptor tyrosine kinase (torso) required for anterior and posterior terminal development of the Drosophila embryo. Injecting eggs with in vitro synthesized torso mRNAs revealed that torso activation is governed by an extracellular molecule, presumably the torso ligand, produced at terminal regions of ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(92)90394-r
更新日期：1992-12-11 00:00:00
abstract：:The expression of the E2A transcription unit of the adenovirus E1A deletion mutant dl312 in murine embryonal carcinoma (EC) stem cells suggests that they contain an activity that will complement viral E1A. We have prepared from these cells in vitro transcription extracts that use E1A-inducible promoters more efficient...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90453-3
更新日期：1987-05-22 00:00:00
abstract：:X-linked recessive chondrodysplasia punctata (CDPX) is a congenital defect of bone and cartilage development characterized by aberrant bone mineralization, severe underdevelopment of nasal cartilage, and distal phalangeal hypoplasia. A virtually identical phenotype is observed in the warfarin embryopathy, which is due...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90367-4
更新日期：1995-04-07 00:00:00
abstract：:Cultured NIH 3T3 cells devoid of endogenous EGF receptors were transfected with cDNA constructs encoding either the human EGF receptor or an EGF receptor mutant in which Lys721, a key residue in the ATP binding site, was replaced with an alanine residue. The mutant receptor was properly processed, and it displayed bot...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(87)90147-4
更新日期：1987-10-23 00:00:00
abstract：:X-linked lissencephaly and "double cortex" are allelic human disorders mapping to Xq22.3-Xq23 associated with arrest of migrating cerebral cortical neurons. We identified a novel 10 kb brain-specific cDNA interrupted by a balanced translocation in an XLIS patient that encodes a novel 40 kDa predicted protein named Dou...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)80899-5
更新日期：1998-01-09 00:00:00
abstract：:Specification of the germ cell lineage is vital to development and heredity. In mice, the germ cell fate is induced in pluripotent epiblast cells by signaling molecules, yet the underlying mechanism remains unknown. Here we demonstrate that germ cell fate in the epiblast is a direct consequence of Bmp4 signaling from ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.03.014
更新日期：2009-05-01 00:00:00
abstract：:Multiple proteins act co-operatively in mammalian clathrin-mediated endocytosis (CME) to generate endocytic vesicles from the plasma membrane. The principles controlling the activation and organization of the actin cytoskeleton during mammalian CME are, however, not fully understood. Here, we show that the protein FCH...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.05.020
更新日期：2018-07-12 00:00:00
abstract：:Antibodies capable of neutralizing divergent influenza A viruses could form the basis of a universal vaccine. Here, from subjects enrolled in an H5N1 DNA/MIV-prime-boost influenza vaccine trial, we sorted hemagglutinin cross-reactive memory B cells and identified three antibody classes, each capable of neutralizing di...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2016.06.043
更新日期：2016-07-28 00:00:00
