Abstract:
:Viruses are adept at evolving or co-opting genomic elements that allow them to maximize their replication potential in the infected host. This evolutionary plasticity makes viruses an invaluable system to identify new mechanisms used not only by viruses but also by vertebrate cells to modulate gene expression. Here, I discuss the identification and characterization of viral mRNA structures and noncoding RNAs that have led to important insights into the molecular mechanisms of eukaryotic cells.
journal_name
Celljournal_title
Cellauthors
Cullen BRdoi
10.1016/j.cell.2009.01.048subject
Has Abstractpub_date
2009-02-20 00:00:00pages
592-7issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(09)00132-9journal_volume
136pub_type
杂志文章相关文献
CELL文献大全abstract::To understand the role of FoxO family members in hematopoiesis, we conditionally deleted FoxO1, FoxO3, and FoxO4 in the adult hematopoietic system. FoxO-deficient mice exhibited myeloid lineage expansion, lymphoid developmental abnormalities, and a marked decrease of the lineage-negative Sca-1+, c-Kit+ (LSK) compartme...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.01.003
更新日期:2007-01-26 00:00:00
abstract::The eukaryotic 20S proteasome is known to associate with the IFN gamma-inducible regulator PA28. We analyzed the kinetics of product generation by 20S proteasomes with and without PA28. In the absence of PA28, the 20S proteasome rapidly generates peptides that have been cleaved only once, while internal fragments accu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80097-5
更新日期:1996-07-26 00:00:00
abstract::The karyophilic properties of the viral matrix (MA) protein govern HIV nuclear import in nondividing cells such as macrophages. A critical regulator of this process is the C-terminal tyrosine phosphorylation of MA during virus maturation. Here, we reveal the mechanism of this phenomenon, by demonstrating that tyrosine...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(95)90097-7
更新日期:1995-11-17 00:00:00
abstract::In Drosophila gonads, Piwi proteins and associated piRNAs collaborate with additional factors to form a small RNA-based immune system that silences mobile elements. Here, we analyzed nine Drosophila piRNA pathway mutants for their impacts on both small RNA populations and the subcellular localization patterns of Piwi ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.03.040
更新日期:2009-05-01 00:00:00
abstract::We propose a mechanism for the priming of influenza viral RNA transcription by capped RNAs in which specific 5'-terminal fragments are cleaved from the capped RNAs by a virion-associated endonuclease. These fragments would serve as the actual primers for the initiation of transcription by the initial incorporation by ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90449-9
更新日期:1981-03-01 00:00:00
abstract::During the postpartum period, the brain's inhibitory GABAA receptors may not recover in time following their reduced numbers during pregnancy. This is likely the cause of postpartum depression prevalent in ∼12% of childbearing women. A new therapy for this condition consists of administering a synthetic neurosteroid d...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.12.016
更新日期:2019-01-10 00:00:00
abstract::We have studied the interaction of highly purified Int protein with DNA restriction fragments from the lambda phage attachment site (attP) region. Two different DNA sequences are protected by bound Int protein against partial digestion by either pancreatic DNAase or neocarzinostatin. One Int binding site includes the ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(79)90049-7
更新日期:1979-10-01 00:00:00
abstract::The emergence of SARS-CoV-2 has driven a global research effort to identify medical countermeasures at an unprecedented pace. In this issue of Cell, Cao et al. identify thousands of SARS-CoV-2 neutralizing antibodies from convalescent donors. The authors improve our understanding of immunity against the coronavirus sp...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2020.06.017
更新日期:2020-07-09 00:00:00
abstract::Eukaryotic cells have developed mechanisms for regulating the nuclear transport of macromolecules that control various cellular events including movement through defined stages of the cell cycle. In yeast cells, where the nuclear envelope remains intact throughout the cell cycle, these transport regulatory mechanisms ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(03)00986-3
更新日期:2003-12-26 00:00:00
abstract::Brassinosteroids (BRs) signal through a plasma membrane-localized receptor kinase to regulate plant growth and development. We showed previously that a novel protein, BES1, accumulates in the nucleus in response to BRs, where it plays a role in BR-regulated gene expression; however, the mechanism by which BES1 regulat...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.11.044
更新日期:2005-01-28 00:00:00
abstract::The subcellular localization of the mouse Ltk transmembrane protein tyrosine kinase was studied in transfected COS cells, a mature B lymphocyte line, and a low expressing transfected lymphocyte clone. Indirect immunofluorescence and immunogold staining of COS transfectants and endoglycosidase analysis of both COS tran...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90114-e
更新日期:1991-08-23 00:00:00
abstract::Prion-like domains have emerged as important drivers of neurodegenerative disease. Now, Boulay et al. establish that the translocated prion-like domain of the oncogenic EWS-FLI1 fusion protein enables phase-separation events, which inappropriately recruit chromatin-remodeling factors to elicit the aberrant transcripti...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2017.09.010
更新日期:2017-09-21 00:00:00
abstract::We have sequenced HFL1 from D. melanogaster, the only cloned hobo element shown to have transposase activity. The 2959 bp HFL1 sequence predicts a 2.0 kb open reading frame (ORF1) with substantial amino acid similarity to the transposases of Activator (Ac) from maize (Zea mays) and Tam3 from snapdragon (Antirrhinum ma...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90010-6
更新日期:1991-08-09 00:00:00
abstract::Eukaryotic translation initiation requires coordinated assembly of a remarkable array of initiation factors onto the small ribosomal subunit to select an appropriate mRNA start codon. Studies from Erzberger et al. and Hussain et al. bring new insights into this mechanism by looking at early and late initiation interme...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2014.10.005
更新日期:2014-10-23 00:00:00
abstract::Xenopus laevis oocytes respond to high temperature (greater than 31 degrees C) by the synthesis of one major (70 kilodalton) protein and by a gradual reduction in the rate of normal protein synthesis. In contrast with most other cells, the heat-shock response of Xenopus oocytes is controlled exclusively at the transla...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90443-3
更新日期:1982-07-01 00:00:00
abstract::A 1.1 kb intron containing an open reading frame (ORF) in one allele (omega+) of the yeast mitochondrial 21S rRNA gene is nearly quantitatively inserted in crosses into a 21S rRNA allele lacking that intron (omega-). We have determined that this nonreciprocal exchange initiates soon after cells fuse to form zygotes an...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(85)90348-4
更新日期:1985-04-01 00:00:00
abstract::We have determined the nucleotide sequence of the transposable maize controlling element Activator (Ac). The Ac element is 4563 bp long and has an imperfect terminal repetition of 11 bp. The element contains two open reading frames (ORF) encoding polypeptides of 839 and 210 amino acids. Evidence derived from structura...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90395-7
更新日期:1984-06-01 00:00:00
abstract::In response to extracellular cues, signal transduction activates downstream transcription factors like c-Jun to induce expression of target genes. We demonstrate that the ATAC (Ada two A containing) histone acetyltransferase (HAT) complex serves as a transcriptional cofactor for c-Jun at the Jun N-terminal kinase (JNK...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.07.045
更新日期:2010-09-03 00:00:00
abstract::Despite an ever-expanding database of sequenced mammalian genomes to be mined for clues, the emergence of the unique human brain remains an evolutionary enigma. In their new study, trawl the human genome and those of other mammals in search of short conserved DNA elements that show extremely rapid evolution only in hu...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2006.09.007
更新日期:2006-09-22 00:00:00
abstract::KRASG12C was recently identified to be potentially druggable by allele-specific covalent targeting of Cys-12 in vicinity to an inducible allosteric switch II pocket (S-IIP). Success of this approach requires active cycling of KRASG12C between its active-GTP and inactive-GDP conformations as accessibility of the S-IIP ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.01.006
更新日期:2018-01-25 00:00:00
abstract::LIM domains are zinc-binding protein sequences that are found in a growing number of proteins, including certain transcriptional regulators, proto-oncogene products, and adhesion plaque constituents. Here we define the biological activity of the LIM domain through studies of an adhesion plaque protein called zyxin tha...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90191-0
更新日期:1994-10-21 00:00:00
abstract::The expression of MHC class II genes is tightly regulated. One form of congenital severe combined immunodeficiency (SCID) is characterized by a regulatory defect that precludes expression of HLA class II genes. B lymphocyte cell lines from such SCID patients provide a tool for identifying putative regulatory proteins ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(88)90389-3
更新日期:1988-06-17 00:00:00
abstract::We have isolated a dominant mutation in a gene called Son of sevenless (Sos) that is an allele-specific suppressor of the sevenless phenotype. This suppressor function is autonomously required in R7 and is sensitive to the dosage of the Sos and bride of sevenless genes. Loss-of-function alleles of Sos are recessive le...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90207-f
更新日期:1991-01-11 00:00:00
abstract::RORγt(+) Th17 cells are important for mucosal defenses but also contribute to autoimmune disease. They accumulate in the intestine in response to microbiota and produce IL-17 cytokines. Segmented filamentous bacteria (SFB) are Th17-inducing commensals that potentiate autoimmunity in mice. RORγt(+) T cells were induced...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.08.061
更新日期:2015-10-08 00:00:00
abstract::Oncogenic activation of RAS genes via point mutations occurs in 20%-30% of human cancers. The development of effective RAS inhibitors has been challenging, necessitating new approaches to inhibit this oncogenic protein. Functional studies have shown that the switch region of RAS interacts with a large number of effect...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.03.045
更新日期:2016-04-21 00:00:00
abstract::Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as "2i" postulated to establish a naive ground state. We show that the transcriptom...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.03.026
更新日期:2012-04-27 00:00:00
abstract::A novel trimolecular mechanism of microbial attachment to mammalian host cells was characterized for the obligate intracellular pathogen Chlamydia trachomatis. Using purified glycosaminoglycans (GAGs) and specific GAG lyases, we demonstrated that a heparan sulfate-like GAG present on the surface of chlamydia organisms...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90296-o
更新日期:1992-05-29 00:00:00
abstract::Synthesis of phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2], a signaling phospholipid, is primarily carried out by phosphatidylinositol 4-phosphate 5-kinase [PI(4)P5K], which has been reported to be regulated by RhoA and Rac1. Unexpectedly, we find that the GTPgammaS-dependent activator of PI(4)P5Kalpha is the smal...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81540-8
更新日期:1999-11-24 00:00:00
abstract::Inhibitor of apoptosis proteins (IAPs) such as XIAP, cIAP1, and cIAP2 are upregulated in many cancer cells. It has been thought that small-molecule mimetics of Smac, an endogenous IAP antagonist, might potentiate apoptosis in cancer cells by promoting caspase activation. However, three recent papers, two in Cell (Vinc...
journal_title:Cell
pub_type: 评论,杂志文章,评审
doi:10.1016/j.cell.2007.10.042
更新日期:2007-11-16 00:00:00
abstract::At anaphase onset, the protease separase triggers chromosome segregation by cleaving the chromosomal cohesin complex. Here, we show that cohesin destruction in metaphase is sufficient for segregation of much of the budding yeast genome, but not of the long arm of chromosome XII that contains the rDNA repeats. rDNA in ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(04)00415-5
更新日期:2004-05-14 00:00:00