Abstract：
:Many neural progenitors, including Drosophila mushroom body (MB) and projection neuron (PN) neuroblasts, sequentially give rise to different subtypes of neurons throughout development. We identified a novel BTB-zinc finger protein, named Chinmo (Chronologically inappropriate morphogenesis), that governs neuronal temporal identity during postembryonic development of the Drosophila brain. In both MB and PN lineages, loss of Chinmo autonomously causes early-born neurons to adopt the fates of late-born neurons from the same lineages. Interestingly, primarily due to a posttranscriptional control, MB neurons born at early developmental stages contain more abundant Chinmo than their later-born siblings. Further, the temporal identity of MB progeny can be transformed toward earlier or later fates by reducing or increasing Chinmo levels, respectively. Taken together, we suggest that a temporal gradient of Chinmo (Chinmo(high) --> Chinmo(low)) helps specify distinct birth order-dependent cell fates in an extended neuronal lineage.
journal_name
Celljournal_title
Cellauthors
Zhu S,Lin S,Kao CF,Awasaki T,Chiang AS,Lee Tdoi
10.1016/j.cell.2006.08.045subject
Has Abstractpub_date
2006-10-20 00:00:00pages
409-22issue
2eissn
0092-8674issn
1097-4172pii
S0092-8674(06)01230-Xjournal_volume
127pub_type
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