Reduced temperature prevents transfer of a membrane glycoprotein to the cell surface but does not prevent terminal glycosylation.

abstract：:We have investigated RNA recombination among poliovirus genomes by analyzing both intratypic and intertypic recombinant crosses involving the same defined genetic markers. Sequence analysis of the recombinant junctions of 13 nonsibling intertypic recombinants showed that intertypic RNA recombination is not site-specif...

journal_title：Cell

authors： Kirkegaard K,Baltimore D

更新日期：1986-11-07 00:00:00

abstract：:Long chain fatty acids (LCFAs) are an important energy substrate used by cardiac myocytes and other cells, but the mechanism whereby these molecules cross the plasma membrane is poorly understood. We used an expression cloning strategy and a cDNA library from 3T3-L1 adipocytes to identify a cDNA that, when expressed i...

journal_title：Cell

authors： Schaffer JE,Lodish HF

更新日期：1994-11-04 00:00:00

abstract：:The transmembrane ligand ephrinB2 and its cognate Eph receptor tyrosine kinases are important regulators of vascular morphogenesis. EphrinB2 may have an active signaling role, resulting in bi-directional signal transduction downstream of both ephrinB2 and Eph receptors. To separate the ligand and receptor-like functio...

journal_title：Cell

authors： Adams RH,Diella F,Hennig S,Helmbacher F,Deutsch U,Klein R

更新日期：2001-01-12 00:00:00

abstract：:The synthesis of histones and DNA was examined in BHK cells arrested in G1 by isoleucine starvation and in cells progressing into the S phase upon isoleucine refeeding. Approximately 2-3% of the cells were not arrested in G1 and synthesized DNA. The rate of synthesis of DNA and nucleosomal histones observed in cells s...

journal_title：Cell

authors： Tarnowka MA,Baglioni C,Basilico C

更新日期：1978-09-01 00:00:00

abstract：:During membrane fusion, the outer leaflets of the two membranes merge first, whereas the distal membrane leaflets remain separate until the opening of a fusion pore. This intermediate stage, called hemifusion, is a critical event shared by exocytosis, protein trafficking, and viral entry. ...

journal_title：Cell

authors： Chernomordik LV,Kozlov MM

更新日期：2005-11-04 00:00:00

abstract：:The human immunodeficiency virus, the lentivirus that causes AIDS, is responsible for the most prevalent epidemic in the history of mankind. Here in this Timeline, we have attempted to illustrate a short history of HIV-1, from its identification in landmark papers published by Robert Gallo, Myron Essex, and Luc Montag...

journal_title：Cell

authors： Agarwal-Jans S

更新日期：2020-10-15 00:00:00

abstract：:We have determined the nucleotide sequence of the transposable maize controlling element Activator (Ac). The Ac element is 4563 bp long and has an imperfect terminal repetition of 11 bp. The element contains two open reading frames (ORF) encoding polypeptides of 839 and 210 amino acids. Evidence derived from structura...

journal_title：Cell

authors： Pohlman RF,Fedoroff NV,Messing J

更新日期：1984-06-01 00:00:00

abstract：:ATP-dependent proteases are vital to maintain cellular protein homeostasis. Here, we study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E. coli to understand how these machines couple ATP hydrolysis to mechanical protein unfolding. Single-molecule analyses reveal that pho...

journal_title：Cell

authors： Sen M,Maillard RA,Nyquist K,Rodriguez-Aliaga P,Pressé S,Martin A,Bustamante C

更新日期：2013-10-24 00:00:00

abstract：:Plasmids expressing partial-length sense or antisense protein 4.1 RNA were microinjected into fertilized Xenopus eggs. Nuclease protection assays reveal that antisense protein 4.1 RNA lead to the specific loss of endogenous protein 4.1 transcripts after midblastula transition, with no effect on the levels of three unr...

journal_title：Cell

authors： Giebelhaus DH,Eib DW,Moon RT

更新日期：1988-05-20 00:00:00

abstract：:Investigating the family tree of a tumor to identify its cellular origins is a daunting task. Liu et al. (2011) now use an elegant lineage tracing technique (MADM) to visualize glioma from its earliest stages. They show that mutations originally induced in neural stem cells lie dormant and only trigger malignant trans...

journal_title：Cell

authors： Sukhdeo K,Hambardzumyan D,Rich JN

更新日期：2011-07-22 00:00:00

abstract：:The specific patterns and functional properties of electrical synapses of a nervous system are defined by the neuron-specific complement of electrical synapse constituents. We systematically examined the molecular composition of the electrical connectome of the nematode C. elegans through a genome- and nervous-system-...

journal_title：Cell

authors： Bhattacharya A,Aghayeva U,Berghoff EG,Hobert O

更新日期：2019-02-21 00:00:00

abstract：:We have localized the regulatory sequence required for viral or poly(I)-poly(C) activation of human beta-interferon gene expression to a region located between -37 and -77 from the mRNA cap site. This sequence has the characteristics of an inducible enhancer element: it can act upstream or downstream of the beta-inter...

journal_title：Cell

authors： Goodbourn S,Zinn K,Maniatis T

更新日期：1985-06-01 00:00:00

abstract：:The sulfated glycosaminoglycan, heparin, was found to release 125I-labeled low density lipoprotein (125I-LDL) from its receptor site on the surface of normal human fibroblasts. Measurement of the amount of 125I-LDL released by heparin permitted the resolution of the total cellular uptake of 125I-LDL at 37 degrees C in...

journal_title：Cell

authors： Goldstein JL,Basu SK,Brunschede GY,Brown MS

更新日期：1976-01-01 00:00:00

abstract：:During development, neurons switch among growth states, such as initial axon outgrowth, axon pruning, and regrowth. By studying the stereotypic remodeling of the Drosophila mushroom body (MB), we found that the heme-binding nuclear receptor E75 is dispensable for initial axon outgrowth of MB γ neurons but is required ...

journal_title：Cell

authors： Rabinovich D,Yaniv SP,Alyagor I,Schuldiner O

更新日期：2016-01-14 00:00:00

abstract：:The pandemic has impacted every scientist differently. Many negative impacts are frequently discussed. Here we highlight unexpected positives that we have found and hope will persist: improved access to experts; deeper and broader human engagement among colleagues, collaborators, and competitors; and significant democ...

journal_title：Cell

authors： Arturo EC,Saphire EO

更新日期：2020-10-01 00:00:00

abstract：:In dividing cells, nuclear pore complexes (NPCs) disassemble during mitosis and reassemble into the newly forming nuclei. However, the fate of nuclear pores in postmitotic cells is unknown. Here, we show that NPCs, unlike other nuclear structures, do not turn over in differentiated cells. While a subset of NPC compone...

journal_title：Cell

authors： D'Angelo MA,Raices M,Panowski SH,Hetzer MW

更新日期：2009-01-23 00:00:00

abstract：:Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to axon demyelination resulting from direct interaction of the M. leprae-specific phenolic glycolipid 1 (PGL-1) with myelinating glia and their subsequent infecti...

journal_title：Cell

authors： Madigan CA,Cambier CJ,Kelly-Scumpia KM,Scumpia PO,Cheng TY,Zailaa J,Bloom BR,Moody DB,Smale ST,Sagasti A,Modlin RL,Ramakrishnan L

更新日期：2017-08-24 00:00:00

abstract：:This year, the Albert Lasker Basic Medical Research Award will be shared by Michael Sheetz, James Spudich, and Ronald Vale for discoveries concerning the biophysical actions of cytoskeletal motor-protein machines that move cargo within cells, contract muscles, and enable cell motility. ...

journal_title：Cell

authors： Ringe D,Petsko GA

更新日期：2012-09-14 00:00:00

abstract：:DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide produc...

journal_title：Cell

authors： Mellor AL,Weiss EH,Kress M,Jay G,Flavell RA

更新日期：1984-01-01 00:00:00

abstract：:The expression of the E2A transcription unit of the adenovirus E1A deletion mutant dl312 in murine embryonal carcinoma (EC) stem cells suggests that they contain an activity that will complement viral E1A. We have prepared from these cells in vitro transcription extracts that use E1A-inducible promoters more efficient...

journal_title：Cell

authors： La Thangue NB,Rigby PW

更新日期：1987-05-22 00:00:00

abstract：:The rabbit alpha-globin DNA insertion in the chimeric plasmid pHb 72 (Liu et al., 1977) has been sequenced by the method of Maxam and Gilbert (1977). This has enabled us to determine the messenger RNA(mRNA) sequence beginning in the 5' untranslated region 9 nucleotides before the initiation codon and extending through...

journal_title：Cell

authors： Heindell HC,Liu A,Paddock GV,Studnicka GM,Salser WA

更新日期：1978-09-01 00:00:00

abstract：:Genetic screening identifies the atypical tetraspanin TM4SF1 as a strong mediator of metastatic reactivation of breast cancer. Intriguingly, TM4SF1 couples the collagen receptor tyrosine kinase DDR1 to the cortical adaptor syntenin 2 and, hence, to PKCα. The latter kinase phosphorylates and activates JAK2, leading to ...

journal_title：Cell

authors： Gao H,Chakraborty G,Zhang Z,Akalay I,Gadiya M,Gao Y,Sinha S,Hu J,Jiang C,Akram M,Brogi E,Leitinger B,Giancotti FG

更新日期：2016-06-30 00:00:00

abstract：:White adipose tissue (WAT) serves as the primary energy depot in the body by storing fat. During development, fat cell precursors (i.e., preadipocytes) undergo a hypertrophic response as they mature into lipid-laden adipocytes. However, the mechanisms that regulate adipocyte size and mass remain undefined. Herein, we ...

journal_title：Cell

authors： Chun TH,Hotary KB,Sabeh F,Saltiel AR,Allen ED,Weiss SJ

更新日期：2006-05-05 00:00:00

abstract：:We describe genetic and physical characterization of rearrangements of chromosome III which result in changes of cell type in S. cerevisiae. Two types of rearrangements were obtained as rare events which caused a change at the locus controlling cell type, MAT, associated with a recessive lethal mutation, in one case f...

journal_title：Cell

authors： Strathern JN,Newlon CS,Herskowitz I,Hicks JB

更新日期：1979-10-01 00:00:00

abstract：:IFN-γ-activated macrophages attempt to limit pathogen growth through tryptophan starvation. Zhang et al. demonstrate that Mycobacterium tuberculosis responds to this threat by synthesizing its own tryptophan. Genetic and chemical inhibition of this pathway reduces mycobacterial survival, revealing a new immune-depende...

journal_title：Cell

authors： Russell DG

更新日期：2013-12-05 00:00:00

abstract：:Following DNA replication, eukaryotic cells must biorient all sister chromatids prior to cohesion cleavage at anaphase. In animal cells, sister chromatids gradually biorient during prometaphase, but current models of mitosis in S. cerevisiae assume that biorientation is established shortly after S phase. This assumpti...

journal_title：Cell

authors： Marco E,Dorn JF,Hsu PH,Jaqaman K,Sorger PK,Danuser G

更新日期：2013-08-29 00:00:00

abstract：:The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear, which unde...

journal_title：Cell

authors： Karavani E,Zuk O,Zeevi D,Barzilai N,Stefanis NC,Hatzimanolis A,Smyrnis N,Avramopoulos D,Kruglyak L,Atzmon G,Lam M,Lencz T,Carmi S

更新日期：2019-11-27 00:00:00

abstract：:Mobile DNAs have had a central role in shaping our genome. More than half of our DNA is comprised of interspersed repeats resulting from replicative copy and paste events of retrotransposons. Although most are fixed, incapable of templating new copies, there are important exceptions to retrotransposon quiescence. De n...

journal_title：Cell

authors： Burns KH,Boeke JD

更新日期：2012-05-11 00:00:00

abstract：:Following EMS mutagenesis we recovered a mutant of D. melanogaster that grows at concentrations of alpha-amanitin lethal to wild-type. To our knowledge this mutant represents the first example of an amanitin-resistant eucaryotic organism. The amanitin resistance of the mutant (AmaC4) is due to an alteration in its DNA...

journal_title：Cell

authors： Greenleaf AL,Borsett LM,Jiamachello PF,Coulter DE

更新日期：1979-11-01 00:00:00

abstract：:Micronuclei of Tetrahymena thermophila contain two electrophoretically distinct forms of histone H3. The slower migrating micronuclear species, H3S, is indistinguishable from the macronuclear H3 by electrophoretic analyses in three gel systems and by partial proteolytic peptide mapping. The faster species, H3F, is uni...

journal_title：Cell

authors： Allis CD,Bowen JK,Abraham GN,Glover CV,Gorovsky MA

更新日期：1980-05-01 00:00:00