Abstract:
:Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I- and double-deficient mice provides data challenging it. There exists a significant population of CD4 single positive cells in class II-deficient animals that is intermediate in maturity between CD4+CD8+ and end-stage CD4+CD8- thymocytes and is selected on class I molecules; an equivalent CD8+CD4- population occurs in class I-deficient animals. We propose a selective model entailing two TCR-MHC molecule engagements: the first provokes random down-modulation of either CD4 or CD8 and a degree of differentiation; the second, requiring participation of the appropriate coreceptor, permits end-stage differentiation.
journal_name
Celljournal_title
Cellauthors
Chan SH,Cosgrove D,Waltzinger C,Benoist C,Mathis Ddoi
10.1016/0092-8674(93)90225-fsubject
Has Abstractpub_date
1993-04-23 00:00:00pages
225-36issue
2eissn
0092-8674issn
1097-4172pii
0092-8674(93)90225-Fjournal_volume
73pub_type
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