Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with beta-catenin/Armadillo.

abstract：:Tumor suppressors block the development of cancer and are often lost during tumor development. Papa et al. show that partial loss of normal PTEN tumor suppressor function can be compounded by additional disruption caused by the expression of inactive mutant PTEN protein. This has significant implications for patients ...

journal_title：Cell

authors： Leslie NR,den Hertog J

更新日期：2014-04-24 00:00:00

abstract：:Dot1 is an evolutionarily conserved histone methyltransferase that methylates lysine-79 of histone H3 in the core domain. Unlike other histone methyltransferases, Dot1 does not contain a SET domain, and it specifically methylates nucleosomal histone H3. We have solved a 2.5 A resolution structure of the catalytic doma...

journal_title：Cell

authors： Min J,Feng Q,Li Z,Zhang Y,Xu RM

更新日期：2003-03-07 00:00:00

abstract：:Receptor-interacting protein kinase (RIPK)-1 is involved in RIPK3-dependent and -independent signaling pathways leading to cell death and/or inflammation. Genetic ablation of ripk1 causes postnatal lethality, which was not prevented by deletion of ripk3, caspase-8, or fadd. However, animals that lack RIPK1, RIPK3, and...

journal_title：Cell

authors： Dillon CP,Weinlich R,Rodriguez DA,Cripps JG,Quarato G,Gurung P,Verbist KC,Brewer TL,Llambi F,Gong YN,Janke LJ,Kelliher MA,Kanneganti TD,Green DR

更新日期：2014-05-22 00:00:00

abstract：:N(6)-methyladenosine (m(6)A) is the most abundant internal modification of messenger RNA. While the presence of m(6)A on transcripts can impact nuclear RNA fates, a reader of this mark that mediates processing of nuclear transcripts has not been identified. We find that the RNA-binding protein HNRNPA2B1 binds m(6)A-be...

journal_title：Cell

authors： Alarcón CR,Goodarzi H,Lee H,Liu X,Tavazoie S,Tavazoie SF

更新日期：2015-09-10 00:00:00

abstract：:While the tumor suppressor functions of p53 have long been recognized, the contribution of p53 to numerous other aspects of disease and normal life is only now being appreciated. This burgeoning range of responses to p53 is reflected by an increasing variety of mechanisms through which p53 can function, although the a...

journal_title：Cell

authors： Vousden KH,Prives C

更新日期：2009-05-01 00:00:00

abstract：:The existence of pseudogenes and the observation of intron loss suggest that RNA can serve as an intermediate in recombination. We used a HIS3 reporter gene to show that RNA-mediated recombination occurs in yeast. His3+ prototroph formation required transcription and expression of the retrotransposon Ty. Two RNA-media...

journal_title：Cell

authors： Derr LK,Strathern JN,Garfinkel DJ

更新日期：1991-10-18 00:00:00

abstract：:Humans are uniquely susceptible to typhoid fever caused by infection with Salmonella enterica serovar Typhi. Mathur et al. now report that mice lacking Toll-like receptor 11, which is absent in humans, can be lethally infected with S. Typhi, a breakthrough that promises to speed the development of better vaccines. ...

journal_title：Cell

authors： Fang FC,Bäumler AJ

更新日期：2012-10-26 00:00:00

abstract：:Clones containing five non-adult beta-globin genes were isolated from a library of BALB/c DNA. Together, the newly cloned regions comprise a contiguous block of 32 kb of the mouse genome. Restriction mapping of genomic DNA established the physical linkage of these non-adult genes to the two adult beta-globin genes as ...

journal_title：Cell

authors： Jahn CL,Hutchison CA 3rd,Phillips SJ,Weaver S,Haigwood NL,Voliva CF,Edgell MH

更新日期：1980-08-01 00:00:00

abstract：:Macroautophagy is a lysosomal degradative pathway essential for neuron survival. Here, we show that macroautophagy requires the Alzheimer's disease (AD)-related protein presenilin-1 (PS1). In PS1 null blastocysts, neurons from mice hypomorphic for PS1 or conditionally depleted of PS1, substrate proteolysis and autopha...

journal_title：Cell

authors： Lee JH,Yu WH,Kumar A,Lee S,Mohan PS,Peterhoff CM,Wolfe DM,Martinez-Vicente M,Massey AC,Sovak G,Uchiyama Y,Westaway D,Cuervo AM,Nixon RA

更新日期：2010-06-25 00:00:00

abstract：:Activins are involved in the regulation of multiple biological events, ranging from early development to pituitary function. To characterize the cellular mechanisms involved in these processes, cDNAs coding for an activin receptor were cloned from AtT20 mouse corticotropic cells by screening COS cell transfectants for...

journal_title：Cell

authors： Mathews LS,Vale WW

更新日期：1991-06-14 00:00:00

abstract：:We have used cloned chicken cDNA sequences for alpha- and beta-tubulin to investigate tubulin gene organization in Drosophila melanogaster. Experiments using genomic Drosophila DNA from several sources indicate that there are at least four copies each of the alpha-tubulin gene and the beta-tubulin gene. In situ hybrid...

journal_title：Cell

authors： Sánchez F,Natzle JE,Cleveland DW,Kirschner MW,McCarthy BJ

更新日期：1980-12-01 00:00:00

abstract：:Physiological concentrations of dihydrotestosterone (DHT) can specifically induce the release of fibrinolysin from androgen-dependent mammary carcinoma (Shionogi SC-115) cells in vitro. No fibrinolytic activity was observed in cells cultured either in the absence of DHT or presence of pharmacological concentrations of...

journal_title：Cell

authors： Mak TW,Rutledge G,Sutherland DJ

更新日期：1976-02-01 00:00:00

abstract：:We have investigated the in vivo functional role of rab5, a small GTPase associated with the plasma membrane and early endosomes. Wild-type rab5 or rab5-ile133, a mutant protein defective in GTP binding, was overexpressed in baby hamster kidney cells. In cells expressing the rab5ile 133 protein, the rate of endocytosi...

journal_title：Cell

authors： Bucci C,Parton RG,Mather IH,Stunnenberg H,Simons K,Hoflack B,Zerial M

更新日期：1992-09-04 00:00:00

abstract：:Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is...

journal_title：Cell

authors： Greenwell PW,Kronmal SL,Porter SE,Gassenhuber J,Obermaier B,Petes TD

更新日期：1995-09-08 00:00:00

abstract：:mRNA made in eukaryotic cells typically has a 3' poly(A) tail that is added posttranscriptionally. To investigate mechanisms by which 3' poly(A) is formed, we identified the genes for the two vaccina virus-encoded polypeptides, VP55 and VP39. Primer-dependent polyadenylation activity was associated exclusively with pu...

journal_title：Cell

authors： Gershon PD,Ahn BY,Garfield M,Moss B

更新日期：1991-09-20 00:00:00

abstract：:While the nuclear lamin proteins (A, B, and C) assemble specifically at the surface of the nuclear membrane, their sequences do not reveal stretches of hydrophobic amino acids that might explain their association with the nuclear membranes. However, the A and B lamin proteins possess Ras-like C-terminal CaaX sequence ...

journal_title：Cell

authors： Holtz D,Tanaka RA,Hartwig J,McKeon F

更新日期：1989-12-22 00:00:00

abstract：:Six restriction fragments of Ad2 DNA which contain sites for RNA initiation have been identified by their ability to hybridize nascent labeled RNA less than 1 kb in length. Four RNA initiation sites early in infection are identified in regions where previous work (Flint, 1977) had mapped mRNAs. The major late RNA init...

journal_title：Cell

authors： Evans RM,Fraser N,Ziff E,Weber J,Wilson M,Darnell JE

更新日期：1977-11-01 00:00:00

abstract：:By chromosome walking in the major histocompatibility complex (MHC) of the BALB/c mouse, we have linked the K region to the I region at the molecular level. Forty-nine overlapping cosmid clones define a stretch of about 600 kb of DNA containing 2 class I and 7 class II genes. Eleven independent recombination events we...

journal_title：Cell

authors： Steinmetz M,Stephan D,Fischer Lindahl K

更新日期：1986-03-28 00:00:00

abstract：:Loss-of-function diseases are often caused by a mutation in a protein traversing the secretory pathway that compromises the normal balance between protein folding, trafficking, and degradation. We demonstrate that the innate cellular protein homeostasis, or proteostasis, capacity can be enhanced to fold mutated enzyme...

journal_title：Cell

authors： Mu TW,Ong DS,Wang YJ,Balch WE,Yates JR 3rd,Segatori L,Kelly JW

更新日期：2008-09-05 00:00:00

abstract：:We have localized the regulatory sequence required for viral or poly(I)-poly(C) activation of human beta-interferon gene expression to a region located between -37 and -77 from the mRNA cap site. This sequence has the characteristics of an inducible enhancer element: it can act upstream or downstream of the beta-inter...

journal_title：Cell

authors： Goodbourn S,Zinn K,Maniatis T

更新日期：1985-06-01 00:00:00

abstract：:Neurons typically settle at positions that match the location of their synaptic targets, creating topographic maps. In the spinal cord, the organization of motor neurons into discrete clusters is linked to the location of their muscle targets, establishing a topographic map of punctate design. To define the significan...

journal_title：Cell

authors： Demireva EY,Shapiro LS,Jessell TM,Zampieri N

更新日期：2011-10-28 00:00:00

abstract：:The organization of a cell emerges from the interactions in protein networks. The interactome is critically dependent on the strengths of interactions and the cellular abundances of the connected proteins, both of which span orders of magnitude. However, these aspects have not yet been analyzed globally. Here, we have...

journal_title：Cell

authors： Hein MY,Hubner NC,Poser I,Cox J,Nagaraj N,Toyoda Y,Gak IA,Weisswange I,Mansfeld J,Buchholz F,Hyman AA,Mann M

更新日期：2015-10-22 00:00:00

abstract：:T cells expressing chimeric antigen receptors (CARs) are promising cancer therapeutic agents, with the prospect of becoming the ultimate smart cancer therapeutics. To expand the capability of CAR T cells, here, we present a split, universal, and programmable (SUPRA) CAR system that simultaneously encompasses multiple ...

journal_title：Cell

authors： Cho JH,Collins JJ,Wong WW

更新日期：2018-05-31 00:00:00

abstract：:Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the ability to initiat...

journal_title：Cell

authors： Briney B,Sok D,Jardine JG,Kulp DW,Skog P,Menis S,Jacak R,Kalyuzhniy O,de Val N,Sesterhenn F,Le KM,Ramos A,Jones M,Saye-Francisco KL,Blane TR,Spencer S,Georgeson E,Hu X,Ozorowski G,Adachi Y,Kubitz M,Sarkar A,Wi

更新日期：2016-09-08 00:00:00

abstract：:Phages must be perfectly attuned to bacterial host cell physiology to ensure their optimal survival. Silpe and Bassler show that a Vibrio phage uses the host quorum-sensing pathway to trigger production of viral progeny at high cell density. ...

journal_title：Cell

authors： Maxwell KL

更新日期：2019-01-10 00:00:00

abstract：:Cis-regulatory elements (CREs) are commonly recognized by correlative chromatin features, yet the molecular composition of the vast majority of CREs in chromatin remains unknown. Here, we describe a CRISPR affinity purification in situ of regulatory elements (CAPTURE) approach to unbiasedly identify locus-specific chr...

journal_title：Cell

authors： Liu X,Zhang Y,Chen Y,Li M,Zhou F,Li K,Cao H,Ni M,Liu Y,Gu Z,Dickerson KE,Xie S,Hon GC,Xuan Z,Zhang MQ,Shao Z,Xu J

更新日期：2017-08-24 00:00:00

abstract：:Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it mea...

journal_title：Cell

authors： Sánchez Alvarado A,Yamanaka S

更新日期：2014-03-27 00:00:00

abstract：:Clinical trials are key to translating scientific advances into progress in cancer research and care. Confronted by developments in basic science, the landscape of clinical cancer research is rapidly evolving. Here, we review recent changes in clinical trials' design and conduct, and we forecast future directions towa...

journal_title：Cell

authors： Cescon D,Siu LL

更新日期：2017-02-09 00:00:00

abstract：:Observational learning is a powerful survival tool allowing individuals to learn about threat-predictive stimuli without directly experiencing the pairing of the predictive cue and punishment. This ability has been linked to the anterior cingulate cortex (ACC) and the basolateral amygdala (BLA). To investigate how inf...

journal_title：Cell

authors： Allsop SA,Wichmann R,Mills F,Burgos-Robles A,Chang CJ,Felix-Ortiz AC,Vienne A,Beyeler A,Izadmehr EM,Glober G,Cum MI,Stergiadou J,Anandalingam KK,Farris K,Namburi P,Leppla CA,Weddington JC,Nieh EH,Smith AC,Ba D,Bro

更新日期：2018-05-31 00:00:00

abstract：:Synaptotagmin is one of the major integral membrane proteins of synaptic vesicles. It has been postulated to dock vesicles to their release sites, to act as the Ca2+ sensor for the release process, and to be a fusion protein during exocytosis. To clarify the function of this protein, we have undertaken a genetic analy...

journal_title：Cell

authors： DiAntonio A,Parfitt KD,Schwarz TL

更新日期：1993-07-02 00:00:00