Rethinking differentiation: stem cells, regeneration, and plasticity.

Abstract:

:Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated cell. Past and recent discoveries in plants and animals, as well as novel experimental manipulations, are beginning to erode many of these established concepts and are forcing a re-evaluation of the experimental systems and paradigms presently being used to explore these and other biological process.

journal_name

Cell

journal_title

Cell

authors

Sánchez Alvarado A,Yamanaka S

doi

10.1016/j.cell.2014.02.041

subject

Has Abstract

pub_date

2014-03-27 00:00:00

pages

110-9

issue

1

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(14)00282-7

journal_volume

157

pub_type

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