Abstract:
:Cell differentiation is an essential process for the development, growth, reproduction, and longevity of all multicellular organisms, and its regulation has been the focus of intense investigation for the past four decades. The study of natural and induced stem cells has ushered an age of re-examination of what it means to be a stem or a differentiated cell. Past and recent discoveries in plants and animals, as well as novel experimental manipulations, are beginning to erode many of these established concepts and are forcing a re-evaluation of the experimental systems and paradigms presently being used to explore these and other biological process.
journal_name
Celljournal_title
Cellauthors
Sánchez Alvarado A,Yamanaka Sdoi
10.1016/j.cell.2014.02.041subject
Has Abstractpub_date
2014-03-27 00:00:00pages
110-9issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(14)00282-7journal_volume
157pub_type
杂志文章,评审相关文献
CELL文献大全abstract::We report the discovery of a short-lived chaperone that is required for the correct maturation of the eukaryotic 20S proteasome and is destroyed at a specific stage of the assembly process. The S. cerevisiae Ump1p protein is a component of proteasome precursor complexes containing unprocessed beta subunits but is not ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80942-3
更新日期:1998-02-20 00:00:00
abstract::This year marks the centenary of Robert Koch's Nobel Prize for discovering the cause of tuberculosis. Koch was also the first scientist to isolate the anthrax and cholera microbes. Yet perhaps one of his greatest contributions to biology is the least appreciated: his method for propagating individual colonies of bacte...
journal_title:Cell
pub_type: 传,历史文章,杂志文章
doi:10.1016/j.cell.2005.11.001
更新日期:2005-11-18 00:00:00
abstract::The existence of pseudogenes and the observation of intron loss suggest that RNA can serve as an intermediate in recombination. We used a HIS3 reporter gene to show that RNA-mediated recombination occurs in yeast. His3+ prototroph formation required transcription and expression of the retrotransposon Ty. Two RNA-media...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90187-4
更新日期:1991-10-18 00:00:00
abstract::The development of solid tumors is regulated by dynamic interactions between evolving neoplastic cells and their microenvironment. Luo et al. (2007) recently demonstrated that tumor-infiltrating immune cells expressing RANKL induce activation and nuclear localization of IKKalpha in prostatic epithelial tumor cells. Th...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2007.03.029
更新日期:2007-04-06 00:00:00
abstract::The extracellular space (ECS) of the brain has an extremely complex spatial organization, which has defied conventional light microscopy. Consequently, despite a marked interest in the physiological roles of brain ECS, its structure and dynamics remain largely inaccessible for experimenters. We combined 3D-STED micros...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.007
更新日期:2018-02-22 00:00:00
abstract::We have identified a novel octamer binding factor (Oct-3) in P19 embryonal carcinoma cells. Oct-3, which recognizes the typical octamer motif (ATTTGCAT) as well as the AT-rich sequence TTAAAATTCA, is present in P19 stem cells but disappears when the cells are induced to differentiate by retinoic acid (RA). Cloned cDNA...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90597-8
更新日期:1990-02-09 00:00:00
abstract::Ras-related GTPases are positively regulated by guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP. The crystal structure of the Sec7 domain GEF bound to nucleotide-free ARF1 GTPase has been determined at 2.8 A resolution and the structure of ARF1 in the GTP-analog form determined at 1...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81754-7
更新日期:1998-10-16 00:00:00
abstract::Neurons in cortical circuits are often coactivated as ensembles, yet it is unclear whether ensembles play a functional role in behavior. Some ensemble neurons have pattern completion properties, triggering the entire ensemble when activated. Using two-photon holographic optogenetics in mouse primary visual cortex, we ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.05.045
更新日期:2019-07-11 00:00:00
abstract::Recombinant E. coli that produce light were found in a clone library of hybrid plasmids containing DNA from the marine bacterium Vibrio fischeri. All luminescent clones had a 16 kb insert that encoded enzymatic activities for the light reaction as well as regulatory functions necessary for expression of the luminescen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(83)90063-6
更新日期:1983-03-01 00:00:00
abstract::The transmission of information across neuronal synapses is an energetically taxing business. Sheng and colleagues monitored the localization of mitochondria following different levels of synaptic activation and discovered that these organelles change their distribution in interesting ways, stalling near synapses when...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2004.12.003
更新日期:2004-12-17 00:00:00
abstract::We have cloned and characterized the rat telomerase protein component 1 gene (TLP1), which is related to the gene for Tetrahymena p80. The cDNA encodes a 2629 amino acid sequence and produces the TLP1 proteins p240 and p230. The anti-TLP1 antibody specifically immunoprecipitated the telomerase activity. Moreover, p240...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81933-9
更新日期:1997-03-21 00:00:00
abstract::We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81002-8
更新日期:1996-01-12 00:00:00
abstract::The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons across a 'bridge' of new tissue, which forms to reconnect a severed nerve. Here we show that blood vessels direct the migrating cord...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.07.021
更新日期:2015-08-27 00:00:00
abstract::Immunofluorescent staining of a pericellular matrix produced by cultured human embryonic skin fibroblasts showed a codistribution among fibronectin, heparan sulfate proteoglycans and part of the chondroitin sulfate in a fibrillar network. Isolated matrix in an "intact" form could be scraped off the dish after detergen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90221-5
更新日期:1982-03-01 00:00:00
abstract::The HIV-1 Tat protein is a potent trans-activator essential for virus replication. We reported previously that HIV-1 Tat peptides containing residues 37-48 (mainly region II), a possible activating region, and residues 49-57 (region III), a nuclear targeting and putative nucleic acid binding region, possess minimal bu...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90417-0
更新日期:1989-07-14 00:00:00
abstract::Activation of the transcription factor NF-kappaB by tumor necrosis factor (TNF) and interleukin-1 (IL-1) requires the NF-kappaB-inducing kinase (NIK). In a yeast two-hybrid screen for NIK-interacting proteins, we have identified a protein kinase previously known as CHUK. Overexpression of CHUK activates a NF-kappaB-de...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80344-x
更新日期:1997-07-25 00:00:00
abstract::The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear, which unde...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2019.10.033
更新日期:2019-11-27 00:00:00
abstract::The looming threat of a new influenza virus pandemic has fueled ambitious efforts to devise more predictive parameters for assessing the risks associated with emergent virus strains. At the same time, a comprehensive understanding of critical factors that can accurately predict the outcome of vaccination is sorely nee...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.023
更新日期:2014-04-10 00:00:00
abstract::The classical model for the activation of the nucleotide exchange factor Son of sevenless (SOS) involves its recruitment to the membrane, where it engages Ras. The recent discovery that Ras*GTP is an allosteric activator of SOS indicated that the regulation of SOS is more complex than originally envisaged. We now pres...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.10.005
更新日期:2004-10-29 00:00:00
abstract::The commitment complex is the first defined step in the yeast (S. cerevisiae) splicing pathway. It contains U1 snRNP as well as Mud2p, which resembles human U2AF65. In a genetic screen, we identified the yeast gene MSL-5, which is a novel commitment complex component. Genetic and biochemical criteria indicate a direct...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80221-4
更新日期:1997-05-02 00:00:00
abstract::Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur, just as the theory of gravitation allows one to understand why cannonballs fly in parabolic arcs. The simplest examples of the eukaryotic ce...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2011.03.006
更新日期:2011-03-18 00:00:00
abstract::Methylation of arginine residues within histone H3 has been linked to active transcription. This modification appears on the estrogen-regulated pS2 promoter when the CARM1 methyltransferase is recruited during transcriptional activation. Here we describe a process, deimination, that converts histone arginine to citrul...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2004.08.020
更新日期:2004-09-03 00:00:00
abstract::The transcription factor HIF-1 mediates adaptive responses to hypoxia, and its activity is negatively regulated by O2-dependent binding of the von Hippel-Lindau (VHL) protein. In this issue, Boutin et al. (2008) use conditional knockout mice to demonstrate that sensing of O2 by keratinocytes in the epidermis leads to ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2008.04.004
更新日期:2008-04-18 00:00:00
abstract::Establishment of left-right asymmetry in vertebrates involves cilia as essential components in the breaking of symmetry, an asymmetric signaling cascade, and a midline barrier that helps to maintain asymmetry. A new study suggests that a reaction-diffusion mechanism also plays a key role. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.09.018
更新日期:2006-10-06 00:00:00
abstract::The alpha-amylase mRNAs which accumulate in two different tissues of the mouse, the salivary gland and the liver, are identical except for their 5' non-translated sequences: the 5' terminal 158 nucleotides of the major liver alpha-amylase mRNA are unrelated to the 5' terminal 47 nucleotides found in its salivary gland...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90140-9
更新日期:1981-02-01 00:00:00
abstract::Twitter needs no introduction. This "microblogging" service has gained tremendous popularity in the 2 years since its launch. Yet, most scientists are steering clear of it. Laura Bonetta speaks to some who have found value in tweeting. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.10.017
更新日期:2009-10-30 00:00:00
abstract::tDNA sequences essential for promotion of transcription have been identified for a tRNA1met gene of X. laevis. A cloned tRNA gene unit was altered by resection of the 5' flanking sequences or by specific deletions of gene and trailing sequences. Gene internal sequences were also substituted by unrelated sequences. The...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90348-2
更新日期:1981-05-01 00:00:00
abstract::A novel method of affinity chromatography on insolubilized collagen-binding fragments of fibronectin was utilized to isolate a random-coil collagenous protein from culture media of mouse teratocarcinoma-derived endodermal cells. These cells also produced another collagenous protein, which did not bind to fibronectin b...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90164-7
更新日期:1982-06-01 00:00:00
abstract::A safe and controlled manipulation of endocytosis in vivo may have disruptive therapeutic potential. Here, we demonstrate that the anti-emetic/anti-psychotic prochlorperazine can be repurposed to reversibly inhibit the in vivo endocytosis of membrane proteins targeted by therapeutic monoclonal antibodies, as directly ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.02.019
更新日期:2020-03-05 00:00:00
abstract::We have purified and characterized a modified peptide pheromone that accumulates in culture medium as B. subtilis grows to high density. This pheromone is required for the development of genetic competence. When added to cells at low density, the pheromone induces the premature development of competence. The peptide m...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(94)90313-1
更新日期:1994-04-22 00:00:00