Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies.

abstract：:Spatiotemporal changes in nuclear lamina composition underlie cell-type-specific chromatin organization and cell fate, suggesting that the lamina forms a dynamic framework critical for genome function, cellular identity, and developmental potential. ...

journal_title：Cell

authors： Van Bortle K,Corces VG

更新日期：2013-03-14 00:00:00

abstract：:Synonymous mutations change the sequence of a gene without directly altering the sequence of the encoded protein. Here, we present evidence that these "silent" mutations frequently contribute to human cancer. Selection on synonymous mutations in oncogenes is cancer-type specific, and although the functional consequenc...

journal_title：Cell

authors： Supek F,Miñana B,Valcárcel J,Gabaldón T,Lehner B

更新日期：2014-03-13 00:00:00

abstract：:Bcl-2 protein is able to repress a number of apoptotic death programs. To investigate the mechanism of Bcl-2's effect, we examined whether Bcl-2 interacted with other proteins. We identified an associated 21 kd protein partner, Bax, that has extensive amino acid homology with Bcl-2, focused within highly conserved dom...

journal_title：Cell

authors： Oltvai ZN,Milliman CL,Korsmeyer SJ

更新日期：1993-08-27 00:00:00

abstract：:Complex gene regulatory networks require transcription factors (TFs) to bind distinct DNA sequences. To understand how novel TF specificity evolves, we combined phylogenetic, biochemical, and biophysical approaches to interrogate how DNA recognition diversified in the steroid hormone receptor (SR) family. After duplic...

journal_title：Cell

authors： McKeown AN,Bridgham JT,Anderson DW,Murphy MN,Ortlund EA,Thornton JW

更新日期：2014-09-25 00:00:00

abstract：:Recent studies suggest that local translation of mRNA within axons plays a key role in two aspects of growth cone navigation. One line of evidence implies a local synthesis of proteins that mediate growth cone collapse and turning in response to guidance cues; another indicates that growth cones possess the machinery ...

journal_title：Cell

authors： Steward O

更新日期：2002-09-06 00:00:00

abstract：:Neurons typically settle at positions that match the location of their synaptic targets, creating topographic maps. In the spinal cord, the organization of motor neurons into discrete clusters is linked to the location of their muscle targets, establishing a topographic map of punctate design. To define the significan...

journal_title：Cell

authors： Demireva EY,Shapiro LS,Jessell TM,Zampieri N

更新日期：2011-10-28 00:00:00

abstract：:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of t...

journal_title：Cell

authors： Zuo T,Wang L,Morrison C,Chang X,Zhang H,Li W,Liu Y,Wang Y,Liu X,Chan MW,Liu JQ,Love R,Liu CG,Godfrey V,Shen R,Huang TH,Yang T,Park BK,Wang CY,Zheng P,Liu Y

更新日期：2007-06-29 00:00:00

abstract：:TET-mediated 5-methyl cytosine (5mC) oxidation acts in epigenetic regulation, stem cell development, and cancer. Hu et al. now determine the crystal structure of the TET2 catalytic domain bound to DNA, shedding light on 5mC-DNA substrate recognition and the catalytic mechanism of 5mC oxidation. ...

journal_title：Cell

authors： Tsai CL,Tainer JA

更新日期：2013-12-19 00:00:00

abstract：:Previous experiments have shown that mRNA translation in frog oocytes can be inhibited by the injection of a complementary antisense RNA. Here we explore the use of antisense RNAs to study the functions of localized maternal mRNAs during postfertilization development. While developmental abnormalities were observed in...

journal_title：Cell

authors： Rebagliati MR,Melton DA

更新日期：1987-02-27 00:00:00

abstract：:During HIV infection, the timing of opportunistic infections is not always associated with severity of CD4 T cell depletion, and different opportunistic pathogens reactivate at different CD4 T cell thresholds. Here, we examine how differences in the phenotype and function of pathogen-specific CD4 T cells influence sus...

journal_title：Cell

authors： Saharia KK,Koup RA

更新日期：2013-10-24 00:00:00

abstract：:Rodent cells resistant to PALA, a specific inhibitor of the aspartate transcarbamylase activity of the multifunctional CAD protein, overproduce CAD as a result of amplification of the CAD gene. We cloned a functional CAD gene from Syrian hamster cells using a cosmid vector. Two independently isolated cosmids containin...

journal_title：Cell

authors： de Saint Vincent BR,Delbrück S,Eckhart W,Meinkoth J,Vitto L,Wahl G

更新日期：1981-12-01 00:00:00

abstract：:A growing body of evidence indicates that plant transcription factors move between cells. A recent paper by Nakajima et al. (2001) shows that movement of the SHORTROOT protein provides a mechanism for signaling positional information between cell layers of the root. ...

journal_title：Cell

authors： Barton MK

更新日期：2001-10-19 00:00:00

abstract：:Many organisms expand the information content of their genome through enzymatic methylation of cytosine residues. Here we report the 2.8 A crystal structure of a bacterial DNA (cytosine-5)-methyltransferase (DCMtase), M. HaeIII, bound covalently to DNA. In this complex, the substrate cytosine is extruded from the DNA ...

journal_title：Cell

authors： Reinisch KM,Chen L,Verdine GL,Lipscomb WN

更新日期：1995-07-14 00:00:00

abstract：:The sphingomyelin pathway, which is initiated by sphingomyelin hydrolysis to generate the second messenger ceramide, signals apoptosis for tumor necrosis factor alpha, Fas, and ionizing radiation. In the present studies, the anticancer drug daunorubicin also stimulated ceramide elevation and apoptosis in P388 and U937...

journal_title：Cell

authors： Bose R,Verheij M,Haimovitz-Friedman A,Scotto K,Fuks Z,Kolesnick R

更新日期：1995-08-11 00:00:00

abstract：:Using a defined RNA polymerase II (pol II) transcription system, we have investigated the roles of basal factors at discrete stages during the transcription cycle (e.g., initiation, promoter clearance, and transcript elongation). Abortive initiation assays revealed that TATA-binding protein, transcription factors TFII...

journal_title：Cell

authors： Goodrich JA,Tjian R

更新日期：1994-04-08 00:00:00

abstract：:For many scientific awards, such as Nobels and Laskers, the maximum number of recipients is three. This Rule of Three forces selection committees to make difficult decisions that increase the likelihood of singling out those individuals who open a new field and continue to lead it. The Rule of Three is reminiscent of ...

journal_title：Cell

authors： Goldstein JL

更新日期：2016-09-22 00:00:00

abstract：:Many cofactors bind the hormone-activated estrogen receptor (ER), yet the specific regulators of endogenous ER-mediated gene transcription are unknown. Using chromatin immunoprecipitation (ChIP), we find that ER and a number of coactivators rapidly associate with estrogen responsive promoters following estrogen treatm...

journal_title：Cell

authors： Shang Y,Hu X,DiRenzo J,Lazar MA,Brown M

更新日期：2000-12-08 00:00:00

abstract：:Ras-related GTPases are positively regulated by guanine nucleotide exchange factors (GEFs) that promote the exchange of GDP for GTP. The crystal structure of the Sec7 domain GEF bound to nucleotide-free ARF1 GTPase has been determined at 2.8 A resolution and the structure of ARF1 in the GTP-analog form determined at 1...

journal_title：Cell

authors： Goldberg J

更新日期：1998-10-16 00:00:00

abstract：:We have identified in mice an allele of a new T cell receptor V beta gene, V beta 17a, whose product is bound by the monoclonal antibody KJ23a. Over 90% of T cell hybridomas prepared from V beta 17a+ T cells of SWR mice respond to allogeneic forms of the IE class II MHC protein, indicating that V beta 17a has an appre...

journal_title：Cell

authors： Kappler JW,Wade T,White J,Kushnir E,Blackman M,Bill J,Roehm N,Marrack P

更新日期：1987-04-24 00:00:00

abstract：:Most bacteria that colonize eukaryotes must bind directly to host cells to establish a replicative niche. In enteric bacteria, adhesion to host cells is often promoted by a lectin found on surface-localized pili. Some pili promote efficient adhesion only when they are subjected to shear stress, as found during the flo...

journal_title：Cell

authors： Isberg RR,Barnes P

更新日期：2002-07-12 00:00:00

abstract：:Invasive lobular carcinoma (ILC) is the second most prevalent histologic subtype of invasive breast cancer. Here, we comprehensively profiled 817 breast tumors, including 127 ILC, 490 ductal (IDC), and 88 mixed IDC/ILC. Besides E-cadherin loss, the best known ILC genetic hallmark, we identified mutations targeting PTE...

journal_title：Cell

authors： Ciriello G,Gatza ML,Beck AH,Wilkerson MD,Rhie SK,Pastore A,Zhang H,McLellan M,Yau C,Kandoth C,Bowlby R,Shen H,Hayat S,Fieldhouse R,Lester SC,Tse GM,Factor RE,Collins LC,Allison KH,Chen YY,Jensen K,Johnson NB,O

更新日期：2015-10-08 00:00:00

abstract：:The treatment of advanced prostate cancer has been transformed by novel antiandrogen therapies such as enzalutamide. Here, we identify induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model, a finding also confirmed in patient samples. GR s...

journal_title：Cell

authors： Arora VK,Schenkein E,Murali R,Subudhi SK,Wongvipat J,Balbas MD,Shah N,Cai L,Efstathiou E,Logothetis C,Zheng D,Sawyers CL

更新日期：2013-12-05 00:00:00

abstract：:Rho and rac, two members of the ras-related superfamily of small GTPases, regulate the polymerization of actin to produce stress fibers and lamellipodia, respectively. We report here that cdc42, another member of the rho family, triggers the formation of a third type of actin-based structure found at the cell peripher...

journal_title：Cell

authors： Nobes CD,Hall A

更新日期：1995-04-07 00:00:00

abstract：:The preprotein translocase of the outer membrane of mitochondria (TOM complex) facilitates the recognition, insertion, and translocation of nuclear-encoded mitochondrial preproteins. We have purified the TOM complex from Neurospora crassa and analyzed its composition and functional properties. The TOM complex contains...

journal_title：Cell

authors： Künkele KP,Heins S,Dembowski M,Nargang FE,Benz R,Thieffry M,Walz J,Lill R,Nussberger S,Neupert W

更新日期：1998-06-12 00:00:00

abstract：:The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons across a 'bridge' of new tissue, which forms to reconnect a severed nerve. Here we show that blood vessels direct the migrating cord...

journal_title：Cell

authors： Cattin AL,Burden JJ,Van Emmenis L,Mackenzie FE,Hoving JJ,Garcia Calavia N,Guo Y,McLaughlin M,Rosenberg LH,Quereda V,Jamecna D,Napoli I,Parrinello S,Enver T,Ruhrberg C,Lloyd AC

更新日期：2015-08-27 00:00:00

abstract：:TFIIH is a multisubunit protein complex that plays an essential role in nucleotide excision repair and transcription of protein-coding genes. Here, we report that TFIIH is also required for ribosomal RNA synthesis in vivo and in vitro. In yeast, pre-rRNA synthesis is impaired in TFIIH ts strains. In a mouse, part of c...

journal_title：Cell

authors： Iben S,Tschochner H,Bier M,Hoogstraten D,Hozák P,Egly JM,Grummt I

更新日期：2002-05-03 00:00:00

abstract：:Embryonic stem cells (ESCs) repress the expression of exogenous proviruses and endogenous retroviruses (ERVs). Here, we systematically dissected the cellular factors involved in provirus repression in embryonic carcinomas (ECs) and ESCs by a genome-wide siRNA screen. Histone chaperones (Chaf1a/b), sumoylation factors ...

journal_title：Cell

authors： Yang BX,El Farran CA,Guo HC,Yu T,Fang HT,Wang HF,Schlesinger S,Seah YF,Goh GY,Neo SP,Li Y,Lorincz MC,Tergaonkar V,Lim TM,Chen L,Gunaratne J,Collins JJ,Goff SP,Daley GQ,Li H,Bard FA,Loh YH

更新日期：2015-09-24 00:00:00

abstract：:The Zika epidemic in the Americas has challenged surveillance and control. As the epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is exacerbated by discrepancies in reporting. To uncover locations with lingering outbreaks, we investigated travel-associated Zika cases to identi...

journal_title：Cell

authors： Grubaugh ND,Saraf S,Gangavarapu K,Watts A,Tan AL,Oidtman RJ,Ladner JT,Oliveira G,Matteson NL,Kraemer MUG,Vogels CBF,Hentoff A,Bhatia D,Stanek D,Scott B,Landis V,Stryker I,Cone MR,Kopp EW 4th,Cannons AC,Heberlein-L

更新日期：2019-08-22 00:00:00

abstract：:Uracil-DNA glycosylase inhibitor (Ugi) is a B. subtilis bacteriophage protein that protects the uracil-containing phage DNA by irreversibly inhibiting the key DNA repair enzyme uracil-DNA glycosylase (UDG). The 1.9 A crystal structure of Ugi complexed to human UDG reveals that the Ugi structure, consisting of a twiste...

journal_title：Cell

authors： Mol CD,Arvai AS,Sanderson RJ,Slupphaug G,Kavli B,Krokan HE,Mosbaugh DW,Tainer JA

更新日期：1995-09-08 00:00:00

abstract：:Protein kinase C (PKC) isozymes have remained elusive cancer targets despite the unambiguous tumor promoting function of their potent ligands, phorbol esters, and the prevalence of their mutations. We analyzed 8% of PKC mutations identified in human cancers and found that, surprisingly, most were loss of function and ...

journal_title：Cell

authors： Antal CE,Hudson AM,Kang E,Zanca C,Wirth C,Stephenson NL,Trotter EW,Gallegos LL,Miller CJ,Furnari FB,Hunter T,Brognard J,Newton AC

更新日期：2015-01-29 00:00:00