Abstract：
:The peripheral nervous system has remarkable regenerative capacities in that it can repair a fully cut nerve. This requires Schwann cells to migrate collectively to guide regrowing axons across a 'bridge' of new tissue, which forms to reconnect a severed nerve. Here we show that blood vessels direct the migrating cords of Schwann cells. This multicellular process is initiated by hypoxia, selectively sensed by macrophages within the bridge, which via VEGF-A secretion induce a polarized vasculature that relieves the hypoxia. Schwann cells then use the blood vessels as "tracks" to cross the bridge taking regrowing axons with them. Importantly, disrupting the organization of the newly formed blood vessels in vivo, either by inhibiting the angiogenic signal or by re-orienting them, compromises Schwann cell directionality resulting in defective nerve repair. This study provides important insights into how the choreography of multiple cell-types is required for the regeneration of an adult tissue.
journal_name
Celljournal_title
Cellauthors
Cattin AL,Burden JJ,Van Emmenis L,Mackenzie FE,Hoving JJ,Garcia Calavia N,Guo Y,McLaughlin M,Rosenberg LH,Quereda V,Jamecna D,Napoli I,Parrinello S,Enver T,Ruhrberg C,Lloyd ACdoi
10.1016/j.cell.2015.07.021subject
Has Abstractpub_date
2015-08-27 00:00:00pages
1127-39issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(15)00898-3journal_volume
162pub_type
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