Abstract：
:The organization of neuronal systems is often dependent on activity and competition between cells. In olfaction, the X-linked OCNC1 channel subunit is subject to random inactivation and is essential for odorant-evoked activity. Reporter-tagged OCNC1 mutant mice permit the visualization of OCNC1-deficient olfactory neurons and their projections. In heterozygous females, X inactivation creates a mosaic with two populations of genetically distinct neurons. OCNC1-deficient neurons are slowly and specifically depleted from the olfactory epithelium and display unusual patterns of projection to the olfactory bulb. Remarkably, this depletion is dependent on odorant exposure and is reversed by odorant deprivation. This suggests that odorants and the activity they evoke are critical for neuronal survival in a competitive environment and implicate evoked activity in the organization and maintenance of the olfactory system.
journal_name
Celljournal_title
Cellauthors
Zhao H,Reed RRdoi
10.1016/s0092-8674(01)00262-8subject
Has Abstractpub_date
2001-03-09 00:00:00pages
651-60issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(01)00262-8journal_volume
104pub_type
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