Abstract：
:daughterless (da) has multiple functions in Drosophila embryonic development: maternal da activity is necessary for proper sex determination, and zygotic da activity is necessary for formation of the peripheral nervous system. We have cloned the region containing da and have found that five recessive lethal da mutations map to a single transcription unit. A predicted protein product of this transcription unit has sequence similarities with the oncogene myc, with the gene MyoD1, which is involved in myoblast determination, and with the Drosophila achaete-scute complex, which is involved in neuronal precursor determination. The role of da as a gene controlling cell determination in multiple developmental pathways is discussed.
journal_name
Celljournal_title
Cellauthors
Caudy M,Vässin H,Brand M,Tuma R,Jan LY,Jan YNdoi
10.1016/0092-8674(88)90250-4subject
Has Abstractpub_date
1988-12-23 00:00:00pages
1061-7issue
6eissn
0092-8674issn
1097-4172pii
0092-8674(88)90250-4journal_volume
55pub_type
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