Abstract:
:In this issue, Stetson et al. (2008) report a mechanism by which host cells avert an autoimmune response to self-nucleic acids. They show that the nuclease Trex1 prevents the accumulation of DNA derived from endogenous retroelements that, if left unchecked, trigger elevated production of type I interferons leading to autoimmunity.
journal_name
Celljournal_title
Cellauthors
Bhoj VG,Chen ZJdoi
10.1016/j.cell.2008.08.010subject
Has Abstractpub_date
2008-08-22 00:00:00pages
569-71issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(08)01018-0journal_volume
134pub_type
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