Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes.

abstract：:The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro. Remarkably, the site of p53 that is acetylated by its coactivator, p300, resides in ...

journal_title：Cell

authors： Gu W,Roeder RG

更新日期：1997-08-22 00:00:00

abstract：:Neurons are frequently classified into distinct types on the basis of structural, physiological, or genetic attributes. To better constrain the definition of neuronal cell types, we characterized the transcriptomes and intrinsic physiological properties of over 4,200 mouse visual cortical GABAergic interneurons and re...

journal_title：Cell

authors： Gouwens NW,Sorensen SA,Baftizadeh F,Budzillo A,Lee BR,Jarsky T,Alfiler L,Baker K,Barkan E,Berry K,Bertagnolli D,Bickley K,Bomben J,Braun T,Brouner K,Casper T,Crichton K,Daigle TL,Dalley R,de Frates RA,Dee N,Dest

更新日期：2020-11-12 00:00:00

abstract：:Telomerase activity was demonstrated in cell-free extracts from S. cerevisiae through the use of a PCR-based assay. As expected, this activity was eliminated by RNase or phenol treatment of the extract and was dependent on dGTP and dTTP. Telomerase was not detected in extracts prepared from cells grown for approximate...

journal_title：Cell

authors： Lin JJ,Zakian VA

更新日期：1995-06-30 00:00:00

abstract：:Monkey cells synthesizing SV40 large T antigen were lysed and the extracts immunoprecipitated with either monoclonal anti-T antibody or monoclonal antibody to p110-114, the product of the retinoblastoma susceptibility gene (Rb). T and p110-114 coprecipitated in each case, implying that the proteins are complexed with ...

journal_title：Cell

authors： DeCaprio JA,Ludlow JW,Figge J,Shew JY,Huang CM,Lee WH,Marsilio E,Paucha E,Livingston DM

更新日期：1988-07-15 00:00:00

abstract：:We have isolated a conditional lethal mutant of bacteriophage 12 which makes plaques only on E. coli strains carrying a UGA suppressor. It grows normally in nonsuppressing hosts but does not lyse such strains. The mutation complements with amber mutations in each of the three known phage cistrons. These observations l...

journal_title：Cell

authors： Model P,Webster RE,Zinder ND

更新日期：1979-10-01 00:00:00

abstract：:The immune system can mount T cell responses against tumors; however, the antigen specificities of tumor-infiltrating lymphocytes (TILs) are not well understood. We used yeast-display libraries of peptide-human leukocyte antigen (pHLA) to screen for antigens of "orphan" T cell receptors (TCRs) expressed on TILs from h...

journal_title：Cell

authors： Gee MH,Han A,Lofgren SM,Beausang JF,Mendoza JL,Birnbaum ME,Bethune MT,Fischer S,Yang X,Gomez-Eerland R,Bingham DB,Sibener LV,Fernandes RA,Velasco A,Baltimore D,Schumacher TN,Khatri P,Quake SR,Davis MM,Garcia KC

更新日期：2018-01-25 00:00:00

abstract：:In Drosophila, the fat body (FB), a functional analog of the vertebrate adipose tissue, is the nutrient sensor that conveys the nutrient status to the insulin-producing cells (IPCs) in the fly brain to release Drosophila insulin-like peptides (Dilps). Dilp secretion in turn regulates energy balance and promotes system...

journal_title：Cell

authors： Rajan A,Perrimon N

更新日期：2012-09-28 00:00:00

abstract：:The emergence of SARS-CoV-2 has driven a global research effort to identify medical countermeasures at an unprecedented pace. In this issue of Cell, Cao et al. identify thousands of SARS-CoV-2 neutralizing antibodies from convalescent donors. The authors improve our understanding of immunity against the coronavirus sp...

journal_title：Cell

authors： Joyce MG,Wheatley AK,Modjarrad K

更新日期：2020-07-09 00:00:00

abstract：:The large tumor antigen (LTag) of simian virus 40, an AAA(+) protein, is a hexameric helicase essential for viral DNA replication in eukaryotic cells. LTag functions as an efficient molecular machine powered by ATP binding and hydrolysis for origin DNA melting and replication fork unwinding. To understand how ATP bind...

journal_title：Cell

authors： Gai D,Zhao R,Li D,Finkielstein CV,Chen XS

更新日期：2004-10-01 00:00:00

abstract：:Inductive signals cause conversion of mesenchyme into epithelia during the formation of many organs. Yet a century of study has not revealed the inducing molecules. Using a standard model of induction, we found that ureteric bud cells secrete factors that convert kidney mesenchyme to epithelia that, remarkably, then f...

journal_title：Cell

authors： Barasch J,Yang J,Ware CB,Taga T,Yoshida K,Erdjument-Bromage H,Tempst P,Parravicini E,Malach S,Aranoff T,Oliver JA

更新日期：1999-11-12 00:00:00

abstract：:Recessive lethal mutations in the T/t-complex of the mouse characteristically show defective genetic complementation, even when they affect very different stages of embryogenesis and are known to be nonallelic. To address the question of their genetic or functional relationship, we have applied the cis-trans test, usi...

journal_title：Cell

authors： Shin HS,McCormick P,Artzt K,Bennett D

更新日期：1983-07-01 00:00:00

abstract：:We find that inactivation of a Drosophila homolog of the tumor suppressor APC (D-APC) causes retinal neuronal degeneration and pigment cell hypertrophy, a phenotype remarkably similar to that found in humans with germline APC mutations. Retinal degeneration in the D-APC mutant results from apoptotic cell death, which ...

journal_title：Cell

authors： Ahmed Y,Hayashi S,Levine A,Wieschaus E

更新日期：1998-06-26 00:00:00

abstract：:Expression of pipe in the somatic tissue of the Drosophila ovary is required for the formation of embryonic dorsal-ventral polarity. pipe, which encodes an enzyme similar to the glycosaminoglycan-modifying enzyme heparan sulfate 2-O-sulfotransferase, is expressed in a spatially restricted domain of follicle cells on t...

journal_title：Cell

authors： Sen J,Goltz JS,Stevens L,Stein D

更新日期：1998-11-13 00:00:00

abstract：:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of t...

journal_title：Cell

authors： Zuo T,Wang L,Morrison C,Chang X,Zhang H,Li W,Liu Y,Wang Y,Liu X,Chan MW,Liu JQ,Love R,Liu CG,Godfrey V,Shen R,Huang TH,Yang T,Park BK,Wang CY,Zheng P,Liu Y

更新日期：2007-06-29 00:00:00

abstract：:Recent biochemical and genetic studies indicate that in addition to the octamer-binding proteins Oct-1 and Oct-2, other B cell components are required for lymphoid-restricted, octamer site-mediated immunoglobulin gene promoter activity. Using a genetic screen in yeast, we have isolated B cell-derived cDNAs encoding Oc...

journal_title：Cell

authors： Strubin M,Newell JW,Matthias P

更新日期：1995-02-10 00:00:00

abstract：:The spectrin superfamily of proteins plays key roles in assembling the actin cytoskeleton in various cell types, crosslinks actin filaments, and acts as scaffolds for the assembly of large protein complexes involved in structural integrity and mechanosensation, as well as cell signaling. α-actinins in particular are t...

journal_title：Cell

authors： Ribeiro Ede A Jr,Pinotsis N,Ghisleni A,Salmazo A,Konarev PV,Kostan J,Sjöblom B,Schreiner C,Polyansky AA,Gkougkoulia EA,Holt MR,Aachmann FL,Zagrović B,Bordignon E,Pirker KF,Svergun DI,Gautel M,Djinović-Carugo K

更新日期：2014-12-04 00:00:00

abstract：:Spatial organization of cellular proteins plays an important role in establishment of cellular polarity to regulate cell division, differentiation, migration, and organogenesis. Activation of T cells by antigen-presenting cells (APCs) results in the formation of an immunological synapse (IS), assembly of a signaling s...

journal_title：Cell

authors： Yeh JH,Sidhu SS,Chan AC

更新日期：2008-03-07 00:00:00

abstract：:p120-catenin regulates cell-cell adhesion by controlling cell surface retention of cadherin. In this issue, Ishiyama et al. (2010) present the first crystal structure of p120 in complex with cadherin, revealing molecular details of the functional interface and providing sophisticated new tools for dissecting p120's ro...

journal_title：Cell

authors： Reynolds AB

更新日期：2010-04-02 00:00:00

abstract：:The mouse kreisler (kr) mutation causes segmentation abnormalities in the caudal hindbrain and defective inner ear development. Based on an inversion discovered in the original kr allele, we selected a candidate cDNA highly expressed in the developing caudal hindbrain. This cDNA encodes a basic domain-leucine zipper (...

journal_title：Cell

authors： Cordes SP,Barsh GS

更新日期：1994-12-16 00:00:00

abstract：:The rate-limiting enzyme of cholesterol biosynthesis, HMG CoA reductase, is controlled by negative feedback regulation of transcription. We have isolated the reductase gene from a bacteriophage lambda genomic library prepared from hamster UT-1 cells. The 25 kilobase gene is split into 20 exons. The 5' untranslated and...

journal_title：Cell

authors： Reynolds GA,Basu SK,Osborne TF,Chin DJ,Gil G,Brown MS,Goldstein JL,Luskey KL

更新日期：1984-08-01 00:00:00

abstract：:Protease-activated receptors (PARs) are a unique class of G protein-coupled receptors that play critical roles in thrombosis, inflammation, and vascular biology. PAR1 is proposed to be involved in the invasive and metastatic processes of various cancers. However, the protease responsible for activating the proinvasive...

journal_title：Cell

authors： Boire A,Covic L,Agarwal A,Jacques S,Sherifi S,Kuliopulos A

更新日期：2005-02-11 00:00:00

abstract：:The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1. Homozygous mutants die at embryonic day 16.5. Their phenotype includes severe craniofac...

journal_title：Cell

authors： Cecconi F,Alvarez-Bolado G,Meyer BI,Roth KA,Gruss P

更新日期：1998-09-18 00:00:00

abstract：:Cholera toxin is assembled from two subunits in the periplasm of Vibrio cholerae and disassembled in the analogous compartment of target cells, the lumen of the endoplasmic reticulum (ER), before a fragment of it, the A1 chain, is transported into the cytosol. We show that protein disulfide isomerase (PDI) in the ER l...

journal_title：Cell

authors： Tsai B,Rodighiero C,Lencer WI,Rapoport TA

更新日期：2001-03-23 00:00:00

abstract：:Negative selection with FUdR produced revertants from the transformed rat line 14B, which contains one insertion of the SV40 viral genome (Botchan, Topp and Sambrook, 1976). 14B contains nuclear T antigen, grows to a high density, grows in low serum and is anchorage-independent. The revertants fall into three classes ...

journal_title：Cell

authors： Steinberg B,Pollack R,Topp W,Botchan M

更新日期：1978-01-01 00:00:00

abstract：:The replication initiator protein of the plasmid R6K binds to seven contiguous 22 bp direct repeats that form an indispensable part of the three replication origins alpha, beta, and gamma. Binding of the initiator to the direct repeats induced a marked bending of the region of gamma replication origin. Binding of the ...

journal_title：Cell

authors： Mukherjee S,Patel I,Bastia D

更新日期：1985-11-01 00:00:00

abstract：:Thymocyte commitment to the CD4 helper versus CD8 cytotoxic lineage has not been satisfactorily established. Two models have been elaborated: one based on instruction, the other on selection. Most previous results support the instructive model, but our comparison of thymocyte differentiation in MHC class II-, class I-...

journal_title：Cell

authors： Chan SH,Cosgrove D,Waltzinger C,Benoist C,Mathis D

更新日期：1993-04-23 00:00:00

abstract：:A transglutaminase-catalyzed cross-linking process characteristic of keratinocytes leads to the formation of the insoluble corneocyte envelope. The essentials of this process take place in vitro in a reconstituted system derived from subcellular fractions. A particulate fraction containing membrane-bound envelope prec...

journal_title：Cell

authors： Simon M,Green H

更新日期：1985-03-01 00:00:00

abstract：:We have reproduced the posttranslational mode of protein translocation across the endoplasmic reticulum membrane with reconstituted proteoliposomes containing a purified complex of seven yeast proteins. This Sec complex includes a heterotrimeric Sec61p complex, homologous to that in mammals, as well as all other membr...

journal_title：Cell

authors： Panzner S,Dreier L,Hartmann E,Kostka S,Rapoport TA

更新日期：1995-05-19 00:00:00

abstract：:Following DNA replication, eukaryotic cells must biorient all sister chromatids prior to cohesion cleavage at anaphase. In animal cells, sister chromatids gradually biorient during prometaphase, but current models of mitosis in S. cerevisiae assume that biorientation is established shortly after S phase. This assumpti...

journal_title：Cell

authors： Marco E,Dorn JF,Hsu PH,Jaqaman K,Sorger PK,Danuser G

更新日期：2013-08-29 00:00:00

abstract：:A glycoprotein of molecular weight 130,000 (gP130) has been precipitated from the cytoplasm of GR-strain mouse mammary tumor (GR-MMT) cells by a rabbit antiserum (anti-MMTV) to GR-strain mouse mammary tumor virus (GR-MMTV). This protein was not precipitated by antisera specific for detergent-disrupted C3H-strain MMTV ...

journal_title：Cell

authors： Anderson SJ,Naso RB

更新日期：1980-10-01 00:00:00