Abstract：
:The tumor suppressor p53 exerts antiproliferation effects through its ability to function as a sequence-specific DNA-binding transcription factor. Here, we demonstrate that p53 can be modified by acetylation both in vivo and in vitro. Remarkably, the site of p53 that is acetylated by its coactivator, p300, resides in a C-terminal domain known to be critical for the regulation of p53 DNA binding. Furthermore, the acetylation of p53 can dramatically stimulate its sequence-specific DNA-binding activity, possibly as a result of an acetylation-induced conformational change. These observations clearly indicate a novel pathway for p53 activation and, importantly, provide an example of an acetylation-mediated change in the function of a nonhistone regulatory protein. These results have significant implications regarding the molecular mechanisms of various acetyltransferase-containing transcriptional coactivators whose primary targets have been presumed to be histones.
journal_name
Celljournal_title
Cellauthors
Gu W,Roeder RGdoi
10.1016/s0092-8674(00)80521-8subject
Has Abstractpub_date
1997-08-22 00:00:00pages
595-606issue
4eissn
0092-8674issn
1097-4172pii
S0092-8674(00)80521-8journal_volume
90pub_type
杂志文章相关文献
CELL文献大全abstract：:There is tremendous enthusiasm for the microbiome in academia and industry. This Perspective argues that in order to realize its potential, the field needs to focus on establishing causation and molecular mechanism with an emphasis on phenotypes that are large in magnitude, easy to measure, and unambiguously driven by...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2018.07.038
更新日期：2018-08-09 00:00:00
abstract：:Mycobacteria are unusual in encoding two GroEL paralogs, GroEL1 and GroEL2. GroEL2 is essential--presumably providing the housekeeping chaperone functions--while groEL1 is nonessential, contains the attB site for phage Bxb1 integration, and encodes a putative chaperone with unusual structural features. Inactivation of...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.09.012
更新日期：2005-12-02 00:00:00
abstract：:Homologous recombination in embryonal stem cells has been used to produce a fusion oncogene, thereby mimicking chromosomal translocations that frequently result in formation of tumor-specific fusion oncogenes in human malignancies. AF9 sequences were fused into the mouse Mll gene so that expression of the Mll-AF9 fusi...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(00)81269-6
更新日期：1996-06-14 00:00:00
abstract：:RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.03.009
更新日期：2010-04-02 00:00:00
abstract：:I have defined conditions under which RepFIC plasmid DNA can be maintained in a state of lowered helical density. In exponentially growing cultures, the DNA of lowered helical density is present in small amounts but never totally absent, suggesting that it is a normal variant of plasmid maintenance. It is fully methyl...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/s0092-8674(01)00402-0
更新日期：2001-06-29 00:00:00
abstract：:Salmonella possesses several flagella, each capable of counterclockwise and clockwise rotation. Counterclockwise rotation produces swimming, clockwise rotation produces tumbling. Switching between senses occurs stochastically. The rotational sense of individual flagella on a single cell could be monitored under specia...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90501-9
更新日期：1983-01-01 00:00:00
abstract：:Tracing the lineage history of cells is key to answering diverse and fundamental questions in biology. Coupling of cell ancestry information with other molecular readouts represents an important goal in the field. Here, we describe the CRISPR array repair lineage tracing (CARLIN) mouse line and corresponding analysis ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.04.048
更新日期：2020-06-11 00:00:00
abstract：:Hematopoietic stem cells (HSCs) develop from a specialized subpopulation of endothelial cells known as hemogenic endothelium (HE). Although the HE origin of HSCs is now well established in different species, the signaling pathways that control this transition remain poorly understood. Here, we show that activation of ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2013.08.055
更新日期：2013-09-26 00:00:00
abstract：:Conversion of glial cells into functional neurons represents a potential therapeutic approach for replenishing neuronal loss associated with neurodegenerative diseases and brain injury. Previous attempts in this area using expression of transcription factors were hindered by the low conversion efficiency and failure o...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2020.03.024
更新日期：2020-04-30 00:00:00
abstract：:mRNA made in eukaryotic cells typically has a 3' poly(A) tail that is added posttranscriptionally. To investigate mechanisms by which 3' poly(A) is formed, we identified the genes for the two vaccina virus-encoded polypeptides, VP55 and VP39. Primer-dependent polyadenylation activity was associated exclusively with pu...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(91)90048-4
更新日期：1991-09-20 00:00:00
abstract：:Embryonal carcinoma cell lines present strong developmental analogies with early embryonic cells. Previous studies have shown that treatment of F9 teratocarcinoma cells with retinoic acid induces the expression of the classical transplantation antigens which are indispensable for effective interactions between cells. ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(83)90179-4
更新日期：1983-12-01 00:00:00
abstract：:In this issue of Cell, Yamamoto et al. (2005) describe a novel molecule, Shisa, which functions in the endoplastic reticulum (ER) to prevent maturation of Frizzled (Fz) serpentine receptors and fibroblast growth factor receptor (FGFR). Shisa thus antagonizes Wnt and FGF signaling cell-autonomously, thereby promoting a...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2005.01.006
更新日期：2005-01-28 00:00:00
abstract：:Little is known about how neutrophils and other cells establish a single zone of actin assembly during migration. A widespread assumption is that the leading edge prevents formation of additional fronts by generating long-range diffusible inhibitors or by sequestering essential polarity components. We use morphologica...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.10.050
更新日期：2012-01-20 00:00:00
abstract：:Plants greatly rely on their root microbiome for uptake of nutrients and protection against stresses. Recent studies have uncovered the involvement of plant stress responses in the assembly of plant-beneficial microbiomes. To facilitate durable crop production, deciphering the driving forces that shape the microbiome ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2018.02.024
更新日期：2018-03-08 00:00:00
abstract：:The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 path...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2017.09.046
更新日期：2017-10-19 00:00:00
abstract：:It is established that tumor cell-derived VEGF acts on endothelial cells to promote angiogenesis and tumor growth. Here, we demonstrate that in K5-SOS-dependent mouse skin tumors, autocrine VEGF is required for tumor cell proliferation in a cell-autonomous and angiogenesis-independent manner. VEGF is upregulated in SO...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2009.12.046
更新日期：2010-01-22 00:00:00
abstract：:X-linked recessive chondrodysplasia punctata (CDPX) is a congenital defect of bone and cartilage development characterized by aberrant bone mineralization, severe underdevelopment of nasal cartilage, and distal phalangeal hypoplasia. A virtually identical phenotype is observed in the warfarin embryopathy, which is due...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(95)90367-4
更新日期：1995-04-07 00:00:00
abstract：:The central vasculature of plant roots is protected by a hydrophobic ring of endodermal cells that are enclosed by lamellae of suberin. Barberon et al. demonstrate that endodermal suberization plasticity facilitates ion homeostasis, with antithetical regulation of suberin deposition and degradation by the phytohormone...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2016.01.005
更新日期：2016-01-28 00:00:00
abstract：:Null mutant mice for retinoic acid receptor gamma 2 (RAR gamma 2) or all RAR gamma isoforms were generated. RAR gamma 2 mutants appeared normal, whereas RAR gamma mutants exhibited growth deficiency, early lethality, and male sterility due to squamous metaplasia of the seminal vesicles and prostate. These defects were...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(93)90246-m
更新日期：1993-05-21 00:00:00
abstract：:Induction of senescence permanently restricts cellular proliferation after oncogenic stimulation thereby acting as a potent barrier to tumor development. The relevant effector proteins may therefore be fundamental to cancer development. A recent study identified IGFBP7 as a secreted factor mediating melanocyte senesce...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2010.04.021
更新日期：2010-05-14 00:00:00
abstract：:The double-stranded RNA-activated protein kinase (PKR) was originally identified as a sensor of virus infection, but its function in the brain remains unknown. Here, we report that the lack of PKR enhances learning and memory in several behavioral tasks while increasing network excitability. In addition, loss of PKR i...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2011.11.029
更新日期：2011-12-09 00:00:00
abstract：:The plant innate immune response includes the hypersensitive response (HR), a form of programmed cell death (PCD). PCD must be restricted to infection sites to prevent the HR from playing a pathologic rather than protective role. Here we show that plant BECLIN 1, an ortholog of the yeast and mammalian autophagy gene A...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2005.03.007
更新日期：2005-05-20 00:00:00
abstract：:The small molecular weight RNAs of the HeLa cell have been located in specific subcellular fractions. SnA is located in the nucleolus and is partially bonded to nucleolar 28S RNA. SnD, the most abundant of the small nuclear RNAs, is partially released from the nucleus when the nuclear preparation is briefly warmed. Sn...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90181-1
更新日期：1976-05-01 00:00:00
abstract：:In causing disease, pathogens outmaneuver host defenses through a dedicated arsenal of virulence determinants that specifically bind or modify individual host molecules. This dedication limits the intruder to a defined range of hosts. Newly emerging diseases mostly involve existing pathogens whose arsenal has been alt...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2007.03.049
更新日期：2007-06-01 00:00:00
abstract：:Nuclear DNA from eucaryotes contains a significant fraction which forms duplexes very rapidly and also independently of the DNA concentration. This fraction can be isolated by adsorption to hydroxylapatite and has been called foldback DNA (Britten and Smith, 1970). Here we extend previous studies to show that the fold...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(76)90182-3
更新日期：1976-05-01 00:00:00
abstract：:Transcription hinders replication fork progression and stability. The ATR checkpoint and specialized DNA helicases assist DNA synthesis across transcription units to protect genome integrity. Combining genomic and genetic approaches together with the analysis of replication intermediates, we searched for factors coord...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2012.09.041
更新日期：2012-11-09 00:00:00
abstract：:Some proteins are too big to fit into conventional COPII-coated vesicles, which raises the question of how large cargo, such as procollagen fibrils, are exported from the endoplasmic reticulum. Jin et al. (2012) in Nature now report that the creation of oversized vesicles is facilitated by the ubiquitination of the CO...
journal_title：Cell
pub_type： 评论,杂志文章
doi：10.1016/j.cell.2012.03.006
更新日期：2012-03-30 00:00:00
abstract：:HNF-3 beta, a transcription factor of the winged-helix family, is expressed in embryonic and adult endoderm and also in midline cells of the node, notochord, and floor plate in mouse embryos. To define the function of HNF-3 beta, a targeted mutation in the HNF-3 beta locus was generated by homologous recombination in ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/0092-8674(94)90523-1
更新日期：1994-08-26 00:00:00
abstract：:Living organisms sense their physical environment through cellular mechanotransduction, which converts mechanical forces into electrical and biochemical signals. In turn, signal transduction serves a wide variety of functions, from basic cellular processes as diverse as proliferation, differentiation, migration, and a...
journal_title：Cell
pub_type： 杂志文章,评审
doi：10.1016/j.cell.2013.09.026
更新日期：2013-10-10 00:00:00
abstract：:Abiotic stress, such as salinity, drought, and cold, causes detrimental yield losses for all major plant crop species. Understanding mechanisms that improve plants' ability to produce biomass, which largely is constituted by the plant cell wall, is therefore of upmost importance for agricultural activities. Cellulose ...
journal_title：Cell
pub_type： 杂志文章
doi：10.1016/j.cell.2015.08.028
更新日期：2015-09-10 00:00:00
