Signal peptides open protein-conducting channels in E. coli.

abstract：:The mammalian BAF complex regulates gene expression by modifying chromatin structure. In this report, we identify 80 genes activated and 2 genes repressed by the BAF complex in SW-13 cells. We find that prior binding of NFI/CTF to the NFI/CTF binding site in CSF1 promoter is required for the recruitment of the BAF com...

journal_title：Cell

authors： Liu R,Liu H,Chen X,Kirby M,Brown PO,Zhao K

更新日期：2001-08-10 00:00:00

abstract：:Coordinated organ behavior is crucial for an effective response to environmental stimuli. By studying regeneration of hair follicles in response to patterned hair plucking, we demonstrate that organ-level quorum sensing allows coordinated responses to skin injury. Plucking hair at different densities leads to a regene...

journal_title：Cell

authors： Chen CC,Wang L,Plikus MV,Jiang TX,Murray PJ,Ramos R,Guerrero-Juarez CF,Hughes MW,Lee OK,Shi S,Widelitz RB,Lander AD,Chuong CM

更新日期：2015-04-09 00:00:00

abstract：:Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose ligand dependency for gene activation remains unknown. Here we report an unexpected and general strategy that ...

journal_title：Cell

authors： Garcia-Bassets I,Kwon YS,Telese F,Prefontaine GG,Hutt KR,Cheng CS,Ju BG,Ohgi KA,Wang J,Escoubet-Lozach L,Rose DW,Glass CK,Fu XD,Rosenfeld MG

更新日期：2007-02-09 00:00:00

abstract：:A key step in the regulation of transcription involves interactions between promoter-selective factors and various components of the transcriptional apparatus. Here we report the requirements for transcriptional activation directed by NTF-1, a developmentally regulated transcription factor in Drosophila. Reconstituted...

journal_title：Cell

authors： Dynlacht BD,Hoey T,Tjian R

更新日期：1991-08-09 00:00:00

abstract：:Maintaining the pluripotency of mouse ES cells requires both LIF (leukemia inhibitory factor) and unknown factors in serum. The paper from Ying et al. in this issue of Cell shows that BMP (bone morphogenetic protein) can replace serum in this capacity, defining molecular requirements for ES cell self-renewal. ...

journal_title：Cell

authors： Temple S

更新日期：2003-10-31 00:00:00

abstract：:Metabolic activity is intimately linked to T cell fate and function. Using high-resolution mass spectrometry, we generated dynamic metabolome and proteome profiles of human primary naive T cells following activation. We discovered critical changes in the arginine metabolism that led to a drop in intracellular L-argini...

journal_title：Cell

authors： Geiger R,Rieckmann JC,Wolf T,Basso C,Feng Y,Fuhrer T,Kogadeeva M,Picotti P,Meissner F,Mann M,Zamboni N,Sallusto F,Lanzavecchia A

更新日期：2016-10-20 00:00:00

abstract：:We have used cloned chicken cDNA sequences for alpha- and beta-tubulin to investigate tubulin gene organization in Drosophila melanogaster. Experiments using genomic Drosophila DNA from several sources indicate that there are at least four copies each of the alpha-tubulin gene and the beta-tubulin gene. In situ hybrid...

journal_title：Cell

authors： Sánchez F,Natzle JE,Cleveland DW,Kirschner MW,McCarthy BJ

更新日期：1980-12-01 00:00:00

abstract：:Hematopoietic stem cells (HSCs) develop from a specialized subpopulation of endothelial cells known as hemogenic endothelium (HE). Although the HE origin of HSCs is now well established in different species, the signaling pathways that control this transition remain poorly understood. Here, we show that activation of ...

journal_title：Cell

authors： Chanda B,Ditadi A,Iscove NN,Keller G

更新日期：2013-09-26 00:00:00

abstract：:ATP-dependent proteases are vital to maintain cellular protein homeostasis. Here, we study the mechanisms of force generation and intersubunit coordination in the ClpXP protease from E. coli to understand how these machines couple ATP hydrolysis to mechanical protein unfolding. Single-molecule analyses reveal that pho...

journal_title：Cell

authors： Sen M,Maillard RA,Nyquist K,Rodriguez-Aliaga P,Pressé S,Martin A,Bustamante C

更新日期：2013-10-24 00:00:00

abstract：:We have isolated five clones containing human histone genes from a human genomic DNA library, using a cloned X. laevis histone H4 cDNA probe (pX1ch4). Each genomic clone has been mapped and the locations of the histone genes have been determined by blot hybridization and hybridization-selection of human histone mRNA. ...

journal_title：Cell

authors： Heintz N,Zernik M,Roeder RG

更新日期：1981-06-01 00:00:00

abstract：:We have transferred the mouse Ak alpha and Ak beta genes, which encode the class II I-Ak molecule, into mouse L-cell fibroblasts and hamster B cells. I-Ak molecules are expressed on the surface of both cell types. The L-cell and hamster B-cell I-Ak molecules appear normal by serological analyses and two-dimensional ge...

journal_title：Cell

authors： Malissen B,Price MP,Goverman JM,McMillan M,White J,Kappler J,Marrack P,Pierres A,Pierres M,Hood L

更新日期：1984-02-01 00:00:00

abstract：:Nontransformed pre-B cells were induced to differentiate in vitro along several different but predictable pathways with only dendritic cells (DC) and concanavalin A-stimulated T lymphocytes. DC-T from spleen induced secretion of only IgM, whereas DC-T from Peyer's patches induced high levels of IgA and intermediate le...

journal_title：Cell

authors： Spalding DM,Griffin JA

更新日期：1986-02-14 00:00:00

abstract：:A large (approximately 200 kd) subunit of cellular RNA polymerase II (Pol II) and a virus-encoded subunit of rabbit poxvirus (RPV) RNA polymerase (137 kd) react with common monoclonal antibodies. Hybridization studies with viral and cellular DNA clones confirm that the viral and cellular proteins are related. Followin...

journal_title：Cell

authors： Morrison DK,Moyer RW

更新日期：1986-02-28 00:00:00

abstract：:Proteolytic fragments of human plasma fibronectin were used to identify monoclonal antibodies reacting with the various domains of fibronectin. One of these antibodies, which reacts with cell-attachment-promoting fragments of fibronectin, inhibits attachment of cells to fibronectin-coated surfaces. A cell-attachment-p...

journal_title：Cell

authors： Pierschbacher MD,Hayman EG,Ruoslahti E

更新日期：1981-10-01 00:00:00

abstract：:A recent report proposed a function of the ubiquitin conjugation factors Rad6 and Rad18 comparable to the bacterial SOS response, controlling damage-induced transcriptional activation and contributing to checkpoint signaling. The relevant ubiquitylation target was identified as budding yeast Rad17, a subunit of the PC...

journal_title：Cell

authors： Davies AA,Neiss A,Ulrich HD

更新日期：2010-06-11 00:00:00

abstract：:M-MuLV-specific DNA probes were used to establish the state of integration and amplification of recombinant proviral sequences in Moloney virus-induced tumors of Balb/Mo, Balb/c and 129 mice. The somatically acquired viral sequences contain both authentic M-MuLV genomes and recombinants of M-MuLV with endogenous viral...

journal_title：Cell

authors： van der Putten H,Quint W,van Raaij J,Maandag ER,Verma IM,Berns A

更新日期：1981-06-01 00:00:00

abstract：:We have analyzed the transcriptional regulation of plastid genes during chloroplast development in illuminated spinach cotyledons and during leaf formation. The RNAs encoded by plastid genes accumulate with different kinetics during the developmental transitions. Using a novel plastid run-on transcription assay we dem...

journal_title：Cell

authors： Deng XW,Gruissem W

更新日期：1987-05-08 00:00:00

abstract：:Forms of RNA polymerase I prepared from growing or encysted Acanthamoeba are equal in the ability to transcribe poly(dl:dC). Polymerase from cysts, whose rRNA genes are transcriptionally inactive, is unable to utilize the rDNA promoter in vitro, whereas the transcription initiation factor from cysts is fully able to b...

journal_title：Cell

authors： Bateman E,Paule MR

更新日期：1986-11-07 00:00:00

abstract：:The plant hormone auxin is central in patterning diverse plant tissues. The direction of auxin flow and the distribution of auxin within tissues are regulated by auxin efflux transporters that are polarly localized in cells. Feedback regulation between auxin and its transporters establishes homeostatic patterns of aux...

journal_title：Cell

authors： Leyser O

更新日期：2005-06-17 00:00:00

abstract：:In many organisms, meiotic chromosomes are bundled at their telomeres to form a "bouquet" arrangement. The bouquet formation plays an important role in homologous chromosome pairing and therefore progression of meiosis. As meiotic telomere clustering occurs in response to mating pheromone signaling in fission yeast, w...

journal_title：Cell

authors： Chikashige Y,Tsutsumi C,Yamane M,Okamasa K,Haraguchi T,Hiraoka Y

更新日期：2006-04-07 00:00:00

abstract：:Targeted gene regulation on a genome-wide scale is a powerful strategy for interrogating, perturbing, and engineering cellular systems. Here, we develop a method for controlling gene expression based on Cas9, an RNA-guided DNA endonuclease from a type II CRISPR system. We show that a catalytically dead Cas9 lacking en...

journal_title：Cell

authors： Qi LS,Larson MH,Gilbert LA,Doudna JA,Weissman JS,Arkin AP,Lim WA

更新日期：2013-02-28 00:00:00

abstract：:Two papers published in 1984 by the Varshavsky laboratory revealed that the ubiquitin/proteasome pathway is the principal system for degradation of short-lived proteins in mammalian cells, setting the stage for future demonstrations of this pathway's many regulatory roles. This perspective discusses the impact of thos...

journal_title：Cell

authors： Pickart CM

更新日期：2004-01-23 00:00:00

abstract：:The hsp 70 gene of Drosophila contains three domains to which a heat shock gene specific transcription factor (HSTF) binds. In addition to the previously described 55 bp binding domain proximal to the TAT homology, there are two 25 bp binding sites farther upstream. Footprinting studies with 5' and 3' deletion mutatio...

journal_title：Cell

authors： Topol J,Ruden DM,Parker CS

更新日期：1985-09-01 00:00:00

abstract：:It was previously demonstrated that the 60,000 dalton (p60) precursor-like polyprotein containing murine p30 was a constituent of the feline leukemia virus pseudotype of Moloney sarcoma virus [m1MSV(FeLV)]. It is now shown that p60 is detected in cells of five mammalian species transformed by m1MSV, indicating that p...

journal_title：Cell

authors： Robey WG,Oskarsson MK,Vande Woude GF,Naso RB,Arlinghaus RB,Haapala DK,Fischinger PJ

更新日期：1977-01-01 00:00:00

abstract：:The chicken immunoglobulin light chain repertoire has been shown to be entirely derived from a single V lambda 1-J rearranged combination. The complete coding information of the lambda locus was determined: it comprises 25 V-hybridizing elements, all of which are pseudogenes, clustered in both orientations within 19 k...

journal_title：Cell

authors： Reynaud CA,Anquez V,Grimal H,Weill JC

更新日期：1987-02-13 00:00:00

abstract：:Salmonella enterica invasion of host cells requires the reversible activation of the Rho-family GTPases Cdc42 and Rac1 by the bacterially encoded GEF SopE and the GAP SptP, which exert their function at different times during infection and are delivered into host cells by a type III secretion system. We found that Sop...

journal_title：Cell

authors： Kubori T,Galán JE

更新日期：2003-10-31 00:00:00

abstract：:The Gin DNA invertase of bacteriophage Mu carries out processive recombination in which multiple rounds of exchange follow synaptic complex formation. The stereostructure of the knotted products determined by electron microscopy establishes critical features of site synapsis and DNA exchange. Surprisingly, the inverta...

journal_title：Cell

authors： Kanaar R,Klippel A,Shekhtman E,Dungan JM,Kahmann R,Cozzarelli NR

更新日期：1990-07-27 00:00:00

abstract：:Gold conjugates have been used to quantitate human transferrin receptors (hTfnRs) on transfected chick embryo fibroblasts. No relationship could be found between the number of hTfnRs and the number of clathrin-coated pits. However, hTfnRs are also associated with flat clathrin lattices that lie outside invaginated pit...

journal_title：Cell

authors： Miller K,Shipman M,Trowbridge IS,Hopkins CR

更新日期：1991-05-17 00:00:00

abstract：:The yeast SIR2 gene is involved in regulating nucleosome phasing and transcription in the mating type system. We have found that SIR2 also plays another important role in the cell. Specifically, in wild-type SIR2 strains recombination between the tandemly repeated ribosomal RNA genes is depressed. In sir2 mutants, bot...

journal_title：Cell

authors： Gottlieb S,Esposito RE

更新日期：1989-03-10 00:00:00

abstract：:The structural organization of the two closely related vitellogenin genes A1 and A2 has been determined and compared by electron microscopy. In both genes the mRNA-coding sequence of 6 kb is interrupted 33 times, leading to a total gene length of 21 kb for gene A1 and 16 kb for gene A2. Thus both genes have a mean exo...

journal_title：Cell

authors： Wahli W,Dawid IB,Wyler T,Weber R,Ryffel GU

更新日期：1980-05-01 00:00:00