Abstract:
:Anatomically modern humans interbred with Neanderthals and with a related archaic population known as Denisovans. Genomes of several Neanderthals and one Denisovan have been sequenced, and these reference genomes have been used to detect introgressed genetic material in present-day human genomes. Segments of introgression also can be detected without use of reference genomes, and doing so can be advantageous for finding introgressed segments that are less closely related to the sequenced archaic genomes. We apply a new reference-free method for detecting archaic introgression to 5,639 whole-genome sequences from Eurasia and Oceania. We find Denisovan ancestry in populations from East and South Asia and Papuans. Denisovan ancestry comprises two components with differing similarity to the sequenced Altai Denisovan individual. This indicates that at least two distinct instances of Denisovan admixture into modern humans occurred, involving Denisovan populations that had different levels of relatedness to the sequenced Altai Denisovan. VIDEO ABSTRACT.
journal_name
Celljournal_title
Cellauthors
Browning SR,Browning BL,Zhou Y,Tucci S,Akey JMdoi
10.1016/j.cell.2018.02.031subject
Has Abstractpub_date
2018-03-22 00:00:00pages
53-61.e9issue
1eissn
0092-8674issn
1097-4172pii
S0092-8674(18)30175-2journal_volume
173pub_type
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