Abstract：
SUMMARY:Disruption of the cyclin-dependent kinase-inhibitory domain of p27 enhances growth of mice. Growth is attributed to an increase in cell number, due to increased cell proliferation, most obviously in tissues that ordinarily express p27 at the highest levels. Disruption of p27 function leads to nodular hyperplasia in the intermediate lobe of the pituitary. However, increased growth occurs without an increase in the amounts of either growth hormone or IGF-I. In addition, female mice were infertile. Luteal cell differentiation is impaired, and a disordered estrus cycle is detected. These results reflect a disturbance of the hypothalamic-pituitary-ovarian axis. The phenotypes of these mice suggest that loss of p27 causes an alteration in cell proliferation that can lead to specific endocrine dysfunction.
journal_name
Celljournal_title
Cellauthors
Kiyokawa H,Kineman RD,Manova-Todorova KO,Soares VC,Hoffman ES,Ono M,Khanam D,Hayday AC,Frohman LA,Koff Adoi
10.1016/s0092-8674(00)81238-6subject
Has Abstractpub_date
1996-05-31 00:00:00pages
721-32issue
5eissn
0092-8674issn
1097-4172pii
S0092-8674(00)81238-6journal_volume
85pub_type
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