Translation silenced by fused pair of tRNA synthetases.

Abstract:

:In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceruloplasmin (Cp), a protein linked to the inflammatory response.

journal_name

Cell

journal_title

Cell

authors

Schimmel P,Ewalt K

doi

10.1016/j.cell.2004.10.001

subject

Has Abstract

pub_date

2004-10-15 00:00:00

pages

147-8

issue

2

eissn

0092-8674

issn

1097-4172

pii

S0092867404009468

journal_volume

119

pub_type

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