Abstract:
:In this issue of Cell, discover gene-specific translational silencing as a novel function of the fused glutamyl- and prolyl-tRNA synthetase (GluProRS). GluProRS is released from a multisynthetase translation complex in response to gamma-interferon and forms a four-protein GAIT complex that silences translation of ceruloplasmin (Cp), a protein linked to the inflammatory response.
journal_name
Celljournal_title
Cellauthors
Schimmel P,Ewalt Kdoi
10.1016/j.cell.2004.10.001subject
Has Abstractpub_date
2004-10-15 00:00:00pages
147-8issue
2eissn
0092-8674issn
1097-4172pii
S0092867404009468journal_volume
119pub_type
评论,杂志文章相关文献
CELL文献大全abstract::Mouse monoclonal antibody 4-I-244 detects a developmentally regulated antigen in embryos of Volvox carteri and inhibits specifically the morphogenetic process of inversion (the process by which the embryo turns inside out). Antigen 4-I-244 was chemically characterized as a complex phytosphingolipid containing the neut...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(86)90889-5
更新日期:1986-08-15 00:00:00
abstract::The relationship between activation of resting chick embryo fibroblasts by proteases and proteolytic alteration of the cell surface has been investigated. Five different proteases were examined: trypsin, collagenase, plasmin, alpha-chymotrypsin, and thrombin. All of these proteases, when added to the culture medium at...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90004-5
更新日期:1975-10-01 00:00:00
abstract::The globin and immunoglobulin multigene families have been used to study the effect of chromosomal organization on the time of gene replication. Some of the genes are late-replicating, providing the first identification of late-replicating sequences that are not highly repetitive. One is a member of the mouse alpha-gl...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(84)90349-0
更新日期:1984-03-01 00:00:00
abstract::The COVID-19 pandemic urgently needs therapeutic and prophylactic interventions. Here, we report the rapid identification of SARS-CoV-2-neutralizing antibodies by high-throughput single-cell RNA and VDJ sequencing of antigen-enriched B cells from 60 convalescent patients. From 8,558 antigen-binding IgG1+ clonotypes, 1...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.05.025
更新日期:2020-07-09 00:00:00
abstract::Induction of broadly neutralizing antibodies (bnAbs) is a primary goal of HIV vaccine development. VRC01-class bnAbs are important vaccine leads because their precursor B cells targeted by an engineered priming immunogen are relatively common among humans. This priming immunogen has demonstrated the ability to initiat...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.08.005
更新日期:2016-09-08 00:00:00
abstract::Significant advances have been made in developing novel therapeutics for cancer treatment, and targeted therapies have revolutionized the treatment of some cancers. Despite the promise, only about five percent of new cancer drugs are approved, and most fail due to lack of efficacy. The indication is that current precl...
journal_title:Cell
pub_type: 杂志文章,评审
doi:10.1016/j.cell.2015.08.068
更新日期:2015-09-24 00:00:00
abstract::Antibodies to DNA and chromatin drive autoimmunity in systemic lupus erythematosus (SLE). Null mutations and hypomorphic variants of the secreted deoxyribonuclease DNASE1L3 are linked to familial and sporadic SLE, respectively. We report that DNASE1L3-deficient mice rapidly develop autoantibodies to DNA and chromatin,...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.05.034
更新日期:2016-06-30 00:00:00
abstract::Immunofluorescent staining of a pericellular matrix produced by cultured human embryonic skin fibroblasts showed a codistribution among fibronectin, heparan sulfate proteoglycans and part of the chondroitin sulfate in a fibrillar network. Isolated matrix in an "intact" form could be scraped off the dish after detergen...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(82)90221-5
更新日期:1982-03-01 00:00:00
abstract::Nuclear receptors undergo ligand-dependent conformational changes that are required for corepressor-coactivator exchange, but whether there is an actual requirement for specific epigenetic landmarks to impose ligand dependency for gene activation remains unknown. Here we report an unexpected and general strategy that ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.12.038
更新日期:2007-02-09 00:00:00
abstract::Liquid-liquid phase separation (LLPS) mediates formation of membraneless condensates such as those associated with RNA processing, but the rules that dictate their assembly, substructure, and coexistence with other liquid-like compartments remain elusive. Here, we address the biophysical mechanism of this multiphase o...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.03.050
更新日期:2020-04-16 00:00:00
abstract::The mTORC1 kinase is a master growth regulator that senses many environmental cues, including amino acids. Activation of mTORC1 by arginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid transporters. Here, we validate that SLC38A9 is an arginine sensor for the mTORC1 path...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2017.09.046
更新日期:2017-10-19 00:00:00
abstract::Mice homozygous for a targeted mutation of the Hoxa-2 (Hox 1.11) gene are born with cleft palates and die within 24 hr of birth. Analysis of stained skeletons revealed that homozygous mutant animals contained multiple cranial skeletal defects, including a duplication of the ossification centers of the bones of the mid...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90619-2
更新日期:1993-12-31 00:00:00
abstract::Using positional cloning strategies, we have identified a CTG triplet repeat that undergoes expansion in myotonic dystrophy patients. This sequence is highly variable in the normal population. PCR analysis of the interval containing this repeat indicates that unaffected individuals have been 5 and 27 copies. Myotonic ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(92)90154-5
更新日期:1992-02-21 00:00:00
abstract::Mitochondrial DNA replication was examined in mutants for seven different Saccharomyces cerevisiae genes which are essential for nuclear DNA replication. In cdc8 and cdc21, mutants defective in continued replication during the S phase of the cell cycle, mitochondrial DNA replication ceases at the nonpermissive tempera...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90061-6
更新日期:1975-08-01 00:00:00
abstract::Poly(A)-containing RNA, isolated from rat ventral prostate, has been analyzed for its base sequence complexity. The kinetics of hybridization of total cellular poly(A)-containing RNA with its complementary DNA (cDNA) from normal and castrated animals are markedly different. RNA from normal animals consists of three ab...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(77)90116-7
更新日期:1977-10-01 00:00:00
abstract::In many organisms, meiotic chromosomes are bundled at their telomeres to form a "bouquet" arrangement. The bouquet formation plays an important role in homologous chromosome pairing and therefore progression of meiosis. As meiotic telomere clustering occurs in response to mating pheromone signaling in fission yeast, w...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.01.048
更新日期:2006-04-07 00:00:00
abstract::The basal ganglia (BG) are critical for adaptive motor control, but the circuit principles underlying their pathway-specific modulation of target regions are not well understood. Here, we dissect the mechanisms underlying BG direct and indirect pathway-mediated control of the mesencephalic locomotor region (MLR), a br...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2015.12.037
更新日期:2016-01-28 00:00:00
abstract::Five years into the human postgenomic era, we are gaining considerable knowledge about host-pathogen interactions through host genomes. This "infectogenomics" approach should yield further insights into both diagnostic and therapeutic advances, as well as normal cellular function. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.02.003
更新日期:2006-02-24 00:00:00
abstract::Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endot...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2011.08.027
更新日期:2011-09-16 00:00:00
abstract::In April this year, a new influenza virus of swine origin emerged in Mexico and spread rapidly around the world. As the Northern hemisphere winter flu season kicks off, Laura Vargas-Parada reports on the measures that Mexico is taking to combat the H1N1 pandemic. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.12.019
更新日期:2009-12-24 00:00:00
abstract::CD4 T cells potentiate the inflammatory or humoral immune response through the action of Th1 and Th2 cells, respectively. The molecular basis of the differentiation of these cells from naive T cell precursors is, however, unclear. We found that GATA-3 was selectively expressed in Th2 cells. GATA-3 is expressed at a hi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80240-8
更新日期:1997-05-16 00:00:00
abstract::The lin-12 gene of C. elegans and the Notch gene of D. melanogaster encode structurally related transmembrane proteins that mediate intercellular signaling. We show that truncated forms of these proteins consisting of only the intracellular domains cause cell fate transformations associated with constitutive activity ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90424-o
更新日期:1993-07-30 00:00:00
abstract::DNA polymerase (pol) β is a model polymerase involved in gap-filling DNA synthesis utilizing two metals to facilitate nucleotidyl transfer. Previous structural studies have trapped catalytic intermediates by utilizing substrate analogs (dideoxy-terminated primer or nonhydrolysable incoming nucleotide). To identify add...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2013.05.048
更新日期:2013-07-03 00:00:00
abstract::The high affinity receptor that binds the Fc domain of immunoglobulin G (IgG) subclasses 1 and 3 (Fc gamma RI) mediates important immune defense functions by inducing cell surface changes on human leukocytes. In this article, we document direct high affinity binding of Fc gamma RI to the actin filament cross-linking p...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90179-3
更新日期:1991-10-18 00:00:00
abstract::Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an intact immune system, but the complex mechanisms regulating tumor immunogenicity have not been elucidated. Here, we discovered an unexpected role of the Hippo pathway in suppressing anti-tumor immunity. We demonstrate that, in three...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2016.11.005
更新日期:2016-12-01 00:00:00
abstract::In female mammals a "random choice" mechanism decides which of the two X chromosomes will be inactivated. It has been postulated that Xist is crucial for heterochromatinization and thus functions downstream of the choice mechanism. Here we report that females heterozygous for an internal deletion in the Xist gene, whi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81133-2
更新日期:1998-03-06 00:00:00
abstract::Screens for agents that specifically kill epithelial cancer stem cells (CSCs) have not been possible due to the rarity of these cells within tumor cell populations and their relative instability in culture. We describe here an approach to screening for agents with epithelial CSC-specific toxicity. We implemented this ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.06.034
更新日期:2009-08-21 00:00:00
abstract::Following TGFbeta receptor-mediated phosphorylation and association with Smad4, Smad2 moves into the nucleus, binds to target promoters in association with DNA-binding cofactors, and recruits coactivators such as p300/CBP to activate transcription. We identified the homeodomain protein TGIF as a Smad2-binding protein ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80712-6
更新日期:1999-04-02 00:00:00
abstract::Propagation of a species requires periodic cell renewal to avoid clonal senescence. Liu et al. (2010) now describe a new mechanism of cell renewal in budding yeast, in which damaged protein aggregates are transported out of the daughter buds along actin cables to preserve youthfulness. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2010.01.015
更新日期:2010-01-22 00:00:00
abstract::Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation factor 1A) lysine 55 (eEF1AK55me2) is utilized by Ras-driven cancers to increase translational output and promote tumorigenesis in vivo. ME...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.11.038
更新日期:2019-01-24 00:00:00