Cellular motility driven by assembly and disassembly of actin filaments.

abstract：:The Eph receptor tyrosine kinase family is regulated by autophosphorylation within the juxtamembrane region and the kinase activation segment. We have solved the X-ray crystal structure to 1.9 A resolution of an autoinhibited, unphosphorylated form of EphB2 comprised of the juxtamembrane region and the kinase domain. ...

journal_title：Cell

authors： Wybenga-Groot LE,Baskin B,Ong SH,Tong J,Pawson T,Sicheri F

更新日期：2001-09-21 00:00:00

abstract：:In order to identify nucleotide sequences required for efficient and accurate polyadenylation of mRNA precursors, we have constructed a series of mutations in the X. laevis beta 1-globin gene and analyzed transcripts produced upon microinjection into Xenopus oocytes. Small deletion and linker replacement mutations, wh...

journal_title：Cell

authors： Mason PJ,Elkington JA,Lloyd MM,Jones MB,Williams JG

更新日期：1986-07-18 00:00:00

abstract：:A mutation in any one of eight spoO genes of Bacillus subtilis blocks the process of spore formation at its earliest stage. To investigate how the products of the spoO genes may be involved in developmental gene expression, we fused the lacZ gene of E. coli to spoVG, a sporulation gene whose induction at the onset of ...

journal_title：Cell

authors： Zuber P,Losick R

更新日期：1983-11-01 00:00:00

abstract：:Post-translational modifications of histone proteins and exchanges of histone variants of chromatin are central to the regulation of nearly all DNA-templated biological processes. However, the degree and variability of chromatin modifications in specific human immune cells remain largely unknown. Here, we employ a hig...

journal_title：Cell

authors： Cheung P,Vallania F,Warsinske HC,Donato M,Schaffert S,Chang SE,Dvorak M,Dekker CL,Davis MM,Utz PJ,Khatri P,Kuo AJ

更新日期：2018-05-31 00:00:00

abstract：:Hunger and thirst have distinct goals but control similar ingestive behaviors, and little is known about neural processes that are shared between these behavioral states. We identify glutamatergic neurons in the peri-locus coeruleus (periLCVGLUT2 neurons) as a polysynaptic convergence node from separate energy-sensiti...

journal_title：Cell

authors： Gong R,Xu S,Hermundstad A,Yu Y,Sternson SM

更新日期：2020-09-17 00:00:00

abstract：:The transition from the juvenile to the adult phase of shoot development in plants is accompanied by changes in vegetative morphology and an increase in reproductive potential. Here, we describe the regulatory mechanism of this transition. We show that miR156 is necessary and sufficient for the expression of the juven...

journal_title：Cell

authors： Wu G,Park MY,Conway SR,Wang JW,Weigel D,Poethig RS

更新日期：2009-08-21 00:00:00

abstract：:Leukocyte adhesion deficiency (LAD) is a heritable disease involving deficient expression of three related leukocyte adhesion glycoproteins: LFA-1, Mac-1, and p150,95. These proteins are alpha beta heterodimers containing identical 95,000 dalton beta subunits. Here we demonstrate that the primary defect in LAD is in t...

journal_title：Cell

authors： Kishimoto TK,Hollander N,Roberts TM,Anderson DC,Springer TA

更新日期：1987-07-17 00:00:00

abstract：:A glycoprotein of molecular weight 130,000 (gP130) has been precipitated from the cytoplasm of GR-strain mouse mammary tumor (GR-MMT) cells by a rabbit antiserum (anti-MMTV) to GR-strain mouse mammary tumor virus (GR-MMTV). This protein was not precipitated by antisera specific for detergent-disrupted C3H-strain MMTV ...

journal_title：Cell

authors： Anderson SJ,Naso RB

更新日期：1980-10-01 00:00:00

abstract：:The eukaryotic 20S proteasome is known to associate with the IFN gamma-inducible regulator PA28. We analyzed the kinetics of product generation by 20S proteasomes with and without PA28. In the absence of PA28, the 20S proteasome rapidly generates peptides that have been cleaved only once, while internal fragments accu...

journal_title：Cell

authors： Dick TP,Ruppert T,Groettrup M,Kloetzel PM,Kuehn L,Koszinowski UH,Stevanović S,Schild H,Rammensee HG

更新日期：1996-07-26 00:00:00

abstract：:Membrane subdomains have been implicated in T cell signaling, although their properties and mechanisms of formation remain controversial. Here, we have used single-molecule and scanning confocal imaging to characterize the behavior of GFP-tagged signaling proteins in Jurkat T cells. We show that the coreceptor CD2, th...

journal_title：Cell

authors： Douglass AD,Vale RD

更新日期：2005-06-17 00:00:00

abstract：:We have analyzed the viral DNA sequences persisting in HE C19, a clonal line of hamster embryo cells transformed in vitro by human adenovirus 12 (Ad 12), a member of highly oncogenic group A. Saturation-hybridization of in vitro labeled Ad 12 DNA (2-4 x 10(8) cpm/mug) with HE C19 DNA showed that 93-100% of viral DNA s...

journal_title：Cell

authors： Green MR,Chinnadurai G,Mackey JK,Green M

更新日期：1976-03-01 00:00:00

abstract：:Secreted proteins of the Wnt family have profound organizing roles during animal development and are transduced via the activities of the Frizzled (Fz) class of transmembrane receptors and the TCF/LEF/Pangolin class of transcription factors. beta-catenins, including Drosophila Armadillo (Arm), link activation of Fz at...

journal_title：Cell

authors： Chan SK,Struhl G

更新日期：2002-10-18 00:00:00

abstract：:The GPA1 gene of S. cerevisiae encodes a G alpha subunit that plays a positive role in the transduction of signals stimulating recovery from pheromone-induced cell cycle arrest. The GPA1Val50 mutation, in which Gly-50 is replaced by valine, causes hyperadaptation to pheromone. However, GPA1Val50 cells do not recover f...

journal_title：Cell

authors： Irie K,Nomoto S,Miyajima I,Matsumoto K

更新日期：1991-05-31 00:00:00

abstract：:Ste5 is a Zn2+ finger-like protein thought to function before three kinases, Ste11 (a MEKK), Ste7 (a MEK), and Fus3 (a MAPK), in a conserved MAP kinase cascade required for mating in S. cerevisiae. Here, we present evidence that Ste5 forms a multikinase complex that joins these kinases for efficient Fus3 activation. B...

journal_title：Cell

authors： Choi KY,Satterberg B,Lyons DM,Elion EA

更新日期：1994-08-12 00:00:00

abstract：:TOR complex 1 (TORC1) is a potent anabolic regulator of cellular growth and metabolism. When cells have sufficient amino acids, TORC1 is active due to its lysosomal localization mediated via the Rag GTPases. Upon amino acid removal, the Rag GTPases release TORC1, causing it to become cytoplasmic and inactive. We show ...

journal_title：Cell

authors： Demetriades C,Doumpas N,Teleman AA

更新日期：2014-02-13 00:00:00

abstract：:A recent report proposed a function of the ubiquitin conjugation factors Rad6 and Rad18 comparable to the bacterial SOS response, controlling damage-induced transcriptional activation and contributing to checkpoint signaling. The relevant ubiquitylation target was identified as budding yeast Rad17, a subunit of the PC...

journal_title：Cell

authors： Davies AA,Neiss A,Ulrich HD

更新日期：2010-06-11 00:00:00

abstract：:Temperature-sensitive mutants of vesicular stomatitis virus (VSV) belonging to complementation group III contain a lesion in the matrix (M) protein. This results in a 2--5 fold increase in transcription at the nonpermissive temperature. Co-infection of cells with one of these mutants and wild-type virus reverses this ...

journal_title：Cell

authors： Clinton GM,Little SP,Hagen FS,Huang AS

更新日期：1978-12-01 00:00:00

abstract：:Five years into the human postgenomic era, we are gaining considerable knowledge about host-pathogen interactions through host genomes. This "infectogenomics" approach should yield further insights into both diagnostic and therapeutic advances, as well as normal cellular function. ...

journal_title：Cell

authors： Kellam P,Weiss RA

更新日期：2006-02-24 00:00:00

abstract：:The spindle pole body (SPB) is the microtubule organizing center (MTOC) in the yeast Saccharomyces that plays a pivotal role in such diverse processes as mitosis, budding, and mating. We have used cryoelectron microscopy and image processing to study the structure of isolated diploid SPBs. We show that SPBs are presen...

journal_title：Cell

authors： Bullitt E,Rout MP,Kilmartin JV,Akey CW

更新日期：1997-06-27 00:00:00

abstract：:Cytoplasmic dynein is a motor protein that exerts force on microtubules. To generate force for the movement of large organelles, dynein needs to be anchored, with the anchoring sites being typically located at the cell cortex. However, the mechanism by which dyneins target sites where they can generate large collectiv...

journal_title：Cell

authors： Ananthanarayanan V,Schattat M,Vogel SK,Krull A,Pavin N,Tolić-Nørrelykke IM

更新日期：2013-06-20 00:00:00

abstract：:Pathogenic and other cytoplasmic DNAs activate the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway to induce inflammation via transcriptional activation by IRF3 and nuclear factor κB (NF-κB), but the functional consequences of exposing cGAS to chromosomes upon mitotic nuclear envelope bre...

journal_title：Cell

authors： Zierhut C,Yamaguchi N,Paredes M,Luo JD,Carroll T,Funabiki H

更新日期：2019-07-11 00:00:00

abstract：:The sequence of about one third of the polyoma virus genome is presented. This sequence covers the origin of replication of two large plaque strains (A2 and A3) of polyoma virus. The two strains differ by 11 bp in the origin region. A model for replication is suggested. The sequence probably also covers the entire cod...

journal_title：Cell

authors： Soeda E,Arrand JR,Smolar N,Griffin BE

更新日期：1979-06-01 00:00:00

abstract：:We examine the interaction between polyoma-virus-encoded middle tumor antigen and the cellular src gene product, pp60c-src, using a series of monoclonal antibodies that recognize mammalian pp60c-src. Our results show that infection of mouse cells with transformation-competent strains of polyoma virus results in the st...

journal_title：Cell

authors： Bolen JB,Thiele CJ,Israel MA,Yonemoto W,Lipsich LA,Brugge JS

更新日期：1984-10-01 00:00:00

abstract：:Hedgehog (Hh) proteins play diverse organizing roles in development by regulating gene expression in responding cells. The Gli homolog Cubitus interruptus (Ci) is involved in controlling the transcription of Hh target genes. A repressor form of Ci arises in the absence of Hh signaling by proteolytic cleavage of intact...

journal_title：Cell

authors： Méthot N,Basler K

更新日期：1999-03-19 00:00:00

abstract：:To assess telomerase as a cancer therapeutic target and determine adaptive mechanisms to telomerase inhibition, we modeled telomerase reactivation and subsequent extinction in T cell lymphomas arising in Atm(-/-) mice engineered with an inducible telomerase reverse transcriptase allele. Telomerase reactivation in the ...

journal_title：Cell

authors： Hu J,Hwang SS,Liesa M,Gan B,Sahin E,Jaskelioff M,Ding Z,Ying H,Boutin AT,Zhang H,Johnson S,Ivanova E,Kost-Alimova M,Protopopov A,Wang YA,Shirihai OS,Chin L,DePinho RA

更新日期：2012-02-17 00:00:00

abstract：:We present genetic evidence that integrins regulate epithelial-mesenchymal interactions during organogenesis. Mice with a mutation in the alpha8 gene do not express the integrin alpha8 beta1 and exhibit profound deficits in kidney morphogenesis. In wild-type animals, inductive interactions between the ureteric epithel...

journal_title：Cell

authors： Müller U,Wang D,Denda S,Meneses JJ,Pedersen RA,Reichardt LF

更新日期：1997-03-07 00:00:00

abstract：:A recombinant peptide encoding the CD11b A domain bound 54Mn2+ with a high affinity. Other divalent cations, including Mg2+, Zn2+, Ni2+, Co2+, and Cd2+, but not Ca2+ or Ba2+, competed effectively for Mn2+ binding. Amino acid substitutions within two conserved and noncontiguous regions in the recombinant peptide abolis...

journal_title：Cell

authors： Michishita M,Videm V,Arnaout MA

更新日期：1993-03-26 00:00:00

abstract：:In this issue of Cell, Korber et al. found that a SARS-CoV-2 variant in the spike protein D614G rapidly became dominant around the world. Although clinical and in vitro data suggest that D614G changes the virus phenotype, the impact of the mutation on transmission, disease, and vaccine and therapeutic development are ...

journal_title：Cell

authors： Grubaugh ND,Hanage WP,Rasmussen AL

更新日期：2020-08-20 00:00:00

abstract：:The p53 tumor suppressor gene is commonly altered in human tumors, predominantly through missense mutations that result in accumulation of mutant p53 protein. These mutations may confer dominant-negative or gain-of-function properties to p53. To ascertain the physiological effects of p53 point mutation, the structural...

journal_title：Cell

authors： Olive KP,Tuveson DA,Ruhe ZC,Yin B,Willis NA,Bronson RT,Crowley D,Jacks T

更新日期：2004-12-17 00:00:00

abstract：:Cell lines stably transfected with metal inducible, MT-fos chimeric genes were used to study the ability of the c-fos gene product, Fos, to act as a transcriptional trans-activator. In 3T3MTfos cells, induction of Fos expression led to specific trans-activation of an AP-1 responsive reporter gene. Induction of Fos exp...

journal_title：Cell

authors： Chiu R,Boyle WJ,Meek J,Smeal T,Hunter T,Karin M

更新日期：1988-08-12 00:00:00