From ER to Eph receptors: new roles for VAP fragments.

Abstract:

:Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and signaling, providing fresh insights into ALS pathogenesis, including non-neuronal aspects of this disorder.

journal_name

Cell

journal_title

Cell

authors

Ackerman SL,Cox GA

doi

10.1016/j.cell.2008.05.028

subject

Has Abstract

pub_date

2008-06-13 00:00:00

pages

949-51

issue

6

eissn

0092-8674

issn

1097-4172

pii

S0092-8674(08)00688-0

journal_volume

133

pub_type

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