Abstract:
:Dominantly inherited mutations in an endoplasmic reticulum protein called VAPB have been found in a subset of patients with a rare familial form of amyotrophic lateral sclerosis (ALS). In this issue, Tsuda et al. (2008) identify a secreted form of VAPB that binds directly to Eph receptors inducing their activation and signaling, providing fresh insights into ALS pathogenesis, including non-neuronal aspects of this disorder.
journal_name
Celljournal_title
Cellauthors
Ackerman SL,Cox GAdoi
10.1016/j.cell.2008.05.028subject
Has Abstractpub_date
2008-06-13 00:00:00pages
949-51issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(08)00688-0journal_volume
133pub_type
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