Abstract:
:Eukaryotic Argonaute proteins strictly mediate RNA-guided RNA interference. In contrast, prokaryotic Argonautes can utilize DNA guides to target complementary DNA sequences to protect their hosts against invading DNA. In this issue of Cell, Jolly and colleagues demonstrate that Thermus thermophilus Argonaute additionally participates in DNA replication by unlinking catenated chromosomes.
journal_name
Celljournal_title
Cellauthors
Swarts DCdoi
10.1016/j.cell.2020.08.037subject
Has Abstractpub_date
2020-09-17 00:00:00pages
1381-1383issue
6eissn
0092-8674issn
1097-4172pii
S0092-8674(20)31079-5journal_volume
182pub_type
杂志文章相关文献
CELL文献大全abstract::We have determined the 2.0 A crystal structure of a fragment of human fibronectin encompassing the seventh through the RGD-containing tenth type III repeats (FN7-10). The structure reveals an extended rod-like molecule with a long axis of approximately 140 A and highly variable relationships between adjacent domains. ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81002-8
更新日期:1996-01-12 00:00:00
abstract::DNA carrying inverted repeats was tested for transposition within the Drosophila genome. Five Bam HI segments containing related inverted repeats were isolated from D. melanogaster and analyzed by electron microscopy and restriction mapping. Southern blot experiments using single-copy flanking sequences as probes allo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90310-4
更新日期:1980-07-01 00:00:00
abstract::Despite tremendous progress made toward the identification of the molecular circuitry that governs cell fate in embryonic stem cells, genes controlling this process in the adult hematopoietic stem cell have proven to be more difficult to unmask. We now report the results of a novel gain-of-function screening approach,...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2009.03.026
更新日期:2009-04-17 00:00:00
abstract::Neurons need to alter their response to a given stimulus over time in order for the animal to modify its behavior within a changing environment. Chen et al. now demonstrate that neuronal structure and function are altered coordinately by the history of the cell's activity through an unexpected molecular pathway. ...
journal_title:Cell
pub_type: 评论,杂志文章
doi:10.1016/j.cell.2012.09.008
更新日期:2012-09-28 00:00:00
abstract::Potassium channels embedded in cell membranes employ gates to regulate K+ current. While a specific constriction in the permeation pathway has historically been implicated in gating, recent reports suggest that the signature ion selectivity filter located in the outer membrane leaflet may be equally important. Inwardl...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2010.05.003
更新日期:2010-06-11 00:00:00
abstract::One of the important events in synapse formation is the accumulation of neurotransmitter receptors beneath the presynaptic nerve terminal. Agrin is a component of the synaptic basal lamina that induces the clustering of acetylcholine receptors when bath-applied to muscle fibers in culture. When a cDNA encoding a putat...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90364-5
更新日期:1991-11-29 00:00:00
abstract::We describe the identification and characterization of the Saccharomyces cerevisiae ZIP2 gene, which encodes a novel meiosis-specific protein essential for synaptonemal complex formation. In the zip2 mutant, chromosomes are homologously paired but not synapsed. The Zip2 protein localizes to discrete foci on meiotic ch...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81164-2
更新日期:1998-05-01 00:00:00
abstract::It is increasingly appreciated that oncogenic transformation alters cellular metabolism to facilitate cell proliferation, but less is known about the metabolic changes that promote cancer cell aggressiveness. Here, we analyzed metabolic gene expression in cancer cell lines and found that a set of high-grade carcinoma ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.07.032
更新日期:2014-08-28 00:00:00
abstract::Cancer cells have distinctive nutrient demands to fuel growth and proliferation, including the disproportionate use of glucose, glutamine, and fatty acids. Comerford et al. and Mashimo et al. now demonstrate that several types of cancer are avid consumers of acetate, which facilitates macromolecular biosynthesis and h...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.12.009
更新日期:2014-12-18 00:00:00
abstract::The cytosolic protein APAF1, human homolog of C. elegans CED-4, participates in the CASPASE 9 (CASP9)-dependent activation of CASP3 in the general apoptotic pathway. We have generated by gene trap a null allele of the murine Apaf1. Homozygous mutants die at embryonic day 16.5. Their phenotype includes severe craniofac...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81732-8
更新日期:1998-09-18 00:00:00
abstract::Steroid hormones induce transcription from the mouse mammary tumor virus (MMTV) promoter by complex mechanisms requiring binding of the hormone receptors to the hormone responsive element (HRE) of the long terminal repeat region. Here we show that the MMTV promoter contains two degenerated octamer motifs immediately u...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(91)90240-y
更新日期:1991-02-08 00:00:00
abstract::T cells expressing chimeric antigen receptors (CARs) are promising cancer therapeutic agents, with the prospect of becoming the ultimate smart cancer therapeutics. To expand the capability of CAR T cells, here, we present a split, universal, and programmable (SUPRA) CAR system that simultaneously encompasses multiple ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.038
更新日期:2018-05-31 00:00:00
abstract::Treatment of the kidney epithelial cell line MDCK with the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) induces a large increase in the permeability of tight junctions within 2-4 hr. This change in transepithelial permeability is accompanied by alterations in cell morphology that include the opening of ti...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(81)90274-9
更新日期:1981-01-01 00:00:00
abstract::Calmodulin is implicated as the primary transducer of the calcium signal in pancreatic beta cells, where it is present at very high concentrations. We have produced three lines of transgenic mice carrying a calmodulin minigene regulated by the rat insulin II promoter. Immunohistochemistry and hybridization analyses in...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(89)90505-9
更新日期:1989-09-22 00:00:00
abstract::Mitochondrial DNA replication was examined in mutants for seven different Saccharomyces cerevisiae genes which are essential for nuclear DNA replication. In cdc8 and cdc21, mutants defective in continued replication during the S phase of the cell cycle, mitochondrial DNA replication ceases at the nonpermissive tempera...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(75)90061-6
更新日期:1975-08-01 00:00:00
abstract::Drosophila Reaper (RPR), Head Involution Defective (HID), and GRIM induce caspase-dependent cell death and physically interact with the cell death inhibitor DIAP1. Here we show that HID blocks DIAP1's ability to inhibit caspase activity and provide evidence suggesting that RPR and GRIM can act similarly. Based on thes...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)81974-1
更新日期:1999-08-20 00:00:00
abstract::Is the Café Scientifique a fashionable by-product of a comfortable age or an indicator of the changing relationship between science and society? ...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2006.07.006
更新日期:2006-07-28 00:00:00
abstract::Every day we make decisions critical for adaptation and survival. We repeat actions with known consequences. But we also draw on loosely related events to infer and imagine the outcome of entirely novel choices. These inferential decisions are thought to engage a number of brain regions; however, the underlying neuron...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2020.08.035
更新日期:2020-10-01 00:00:00
abstract::The organization of mouse immunoglobulin heavy chain genes has been investigated by hybridization with cloned mu and alpha cDNA probes. Restriction endonuclease fragments bearing mu and alpha constant region genes and two types of variable region (VH) genes were compared in BALB/c embryos, liver and nine plasmacytomas...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(80)90386-4
更新日期:1980-01-01 00:00:00
abstract::RECQL5 is the sole member of the RECQ family of helicases associated with RNA polymerase II (RNAPII). We now show that RECQL5 is a general elongation factor that is important for preserving genome stability during transcription. Depletion or overexpression of RECQL5 results in corresponding shifts in the genome-wide R...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2014.03.048
更新日期:2014-05-22 00:00:00
abstract::Herpes simplex virus type 1 (HSV-1) binds to cells through interactions of viral glycoproteins gB and gC with heparan sulfate chains on cell surface proteoglycans. This binding is not sufficient for viral entry, which requires fusion between the viral envelope and cell membrane. Here, we show that heparan sulfate modi...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(00)80058-6
更新日期:1999-10-01 00:00:00
abstract::In this issue of Cell, a study by Valerie Mizrahi and her colleagues suggests that a putative error-prone DNA polymerase encoded by the dnaE2 gene of Mycobacterium tuberculosis may bypass certain types of DNA base damage, generating mutations. This may be an important mechanism for generating drug-resistant strains of...
journal_title:Cell
pub_type: 评论,杂志文章,评审
doi:10.1016/s0092-8674(03)00275-7
更新日期:2003-04-18 00:00:00
abstract::In Drosophila melanogaster males, the sex chromosomes pair during meiosis in the centric X heterochromatin and at the base of the short arm of the Y (YS), in the vicinity of the nucleolus organizers. X chromosomes deficient for the pairing region segregate randomly from the Y. In this report we show that a single ribo...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90215-z
更新日期:1990-04-06 00:00:00
abstract::A strong transcription enhancer was identified in the genomic DNA (235 kb) of human cytomegalovirus (HCMV), a ubiquitous and severe pathogen of the herpesvirus group. Cotransfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-HCMV recombinant viruses that had incorporated overlapping se...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(85)80025-8
更新日期:1985-06-01 00:00:00
abstract::Mouse embryonic stem (ES) cells grown in serum exhibit greater heterogeneity in morphology and expression of pluripotency factors than ES cells cultured in defined medium with inhibitors of two kinases (Mek and GSK3), a condition known as "2i" postulated to establish a naive ground state. We show that the transcriptom...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2012.03.026
更新日期:2012-04-27 00:00:00
abstract::The HIV-1 trans-activator Tat increases levels of viral gene expression and replication. The target for Tat is an RNA stem-loop called TAR, located at the 5' end of all viral transcripts. To study the mechanism of action and map functional domains of Tat, we fused Tat to the coat protein of bacteriophage MS2, an RNA b...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(90)90121-t
更新日期:1990-08-24 00:00:00
abstract::High-grade serous ovarian cancer (HGSC) exhibits extensive malignant clonal diversity with widespread but non-random patterns of disease dissemination. We investigated whether local immune microenvironment factors shape tumor progression properties at the interface of tumor-infiltrating lymphocytes (TILs) and cancer c...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.03.073
更新日期:2018-06-14 00:00:00
abstract::Retrotransposons have shaped eukaryotic genomes for millions of years. To analyze the consequences of human L1 retrotransposition, we developed a genetic system to recover many new L1 insertions in somatic cells. Forty-two de novo integrants were recovered that faithfully mimic many aspects of L1s that accumulated sin...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/s0092-8674(02)00839-5
更新日期:2002-08-09 00:00:00
abstract::The extracellular space (ECS) of the brain has an extremely complex spatial organization, which has defied conventional light microscopy. Consequently, despite a marked interest in the physiological roles of brain ECS, its structure and dynamics remain largely inaccessible for experimenters. We combined 3D-STED micros...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/j.cell.2018.02.007
更新日期:2018-02-22 00:00:00
abstract::The phenotype of the autosomal recessive mutation scat includes severe intermittent bleeding, depletion of platelets, and circulating anti-platelet antibodies. In this study, we have mapped the scat mutation to mouse chromosome 8 and shown that the immune component is a secondary consequence of the gene defect. Surpri...
journal_title:Cell
pub_type: 杂志文章
doi:10.1016/0092-8674(93)90301-6
更新日期:1993-07-16 00:00:00