Abstract：
:Long chain fatty acids (LCFAs) are an important energy substrate used by cardiac myocytes and other cells, but the mechanism whereby these molecules cross the plasma membrane is poorly understood. We used an expression cloning strategy and a cDNA library from 3T3-L1 adipocytes to identify a cDNA that, when expressed in cultured cells, augments uptake of LCFAs. This cDNA encodes a novel 646 amino acid fatty acid transport protein (FATP) with six predicted membrane-spanning regions and that is integrally associated with membranes. Immunocytochemistry and subcellular fractionation of 3T3-L1 adipocytes show that FATP is localized to the plasma membrane. We propose that FATP is a plasma membrane transporter for LCFAs.
journal_name
Celljournal_title
Cellauthors
Schaffer JE,Lodish HFdoi
10.1016/0092-8674(94)90252-6subject
Has Abstractpub_date
1994-11-04 00:00:00pages
427-36issue
3eissn
0092-8674issn
1097-4172pii
0092-8674(94)90252-6journal_volume
79pub_type
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